2. Gene
  3. Jag2 - jagged 2 Gene

Jag2 - jagged 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as sm; Serh; D12Ggc2e; mJagged2-1

Gene ID: 16450 | Gene type: protein coding

About Jag2

Summary

Enables Notch binding activity. Involved in auditory receptor cell fate commitment; gamma-delta T cell differentiation; and positive regulation of Notch signaling pathway. Acts upstream of or within several processes, including epithelial cell apoptotic process involved in palatal shelf morphogenesis; odontogenesis of dentin-containing tooth; and respiratory system process. Located in membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and surface ectoderm. Orthologous to human JAG2 (jagged canonical Notch ligand 2). [provided by Alliance of Genome Resources, Apr 2022]

Jag2 Products(2)

mRNA Protein Name
NM_001409685.1 NP_001396614.1 protein jagged-2 isoform 2 precursor
NM_010588.3 NP_034718.2 protein jagged-2 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables Notch binding IPI
IPI: Inferred from physical interaction
10958687 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12496659 MGI
Biological Process GO Annotation Evidence Reference Source
involved in auditory receptor cell fate commitment IMP
IMP: Inferred from mutant phenotype
10080181 MGI
acts upstream of or within epithelial cell apoptotic process involved in palatal shelf morphogenesis IMP
IMP: Inferred from mutant phenotype
16607638 MGI
involved in gamma-delta T cell differentiation IMP
IMP: Inferred from mutant phenotype
10383933 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
9531541 MGI
acts upstream of or within morphogenesis of embryonic epithelium IMP
IMP: Inferred from mutant phenotype
16607638 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IMP
IMP: Inferred from mutant phenotype
15721140 MGI
involved in positive regulation of Notch signaling pathway IDA
IDA: Inferred from direct assay
10958687 MGI
acts upstream of or within regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
16607638 MGI
acts upstream of or within respiratory system process IMP
IMP: Inferred from mutant phenotype
9531541 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
15721140 MGI
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
15886206 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10910909 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein jagged-2

syndactylism

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07013 JAG2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19343 Jag2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25834 Jag2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Jag2 NCBI NCBI:3714