Irx3 - Iroquois related homeobox 3 Gene

Mus musculus

Gene ID: 16373 | Gene type: protein coding

About Irx3

Summary

Enables DNA-binding transcription activator activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including His-Purkinje system development; energy homeostasis; and regulation of transcription by RNA polymerase II. Acts upstream of or within kidney development; mesoderm development; and regulation of neuron differentiation. Located in axon; cytoplasm; and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; heart; limb; and sensory organ. Orthologous to human IRX3 (iroquois homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]

Irx3 Products(2)

mRNA	Protein	Name
NM_001253822.1	NP_001240751.1	iroquois-class homeodomain protein IRX-3 isoform 1
NM_008393.3	NP_032419.2	iroquois-class homeodomain protein IRX-3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	21825130	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	21825130	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21825130	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in His-Purkinje system cell differentiation	IMP IMP: Inferred from mutant phenotype	26786475	MGI
involved in Purkinje myocyte development	IMP IMP: Inferred from mutant phenotype	26786475	MGI
involved in atrioventricular bundle cell differentiation	IMP IMP: Inferred from mutant phenotype	26786475	MGI
involved in energy homeostasis	IDA IDA: Inferred from direct assay	24646999	MGI
acts upstream of or within mesoderm development	IGI IGI: Inferred from genetic interaction	11124112	MGI
involved in metanephros development	IEP IEP: Inferred from expression pattern	17875669	MGI
acts upstream of or within negative regulation of neuron differentiation	IDA IDA: Inferred from direct assay	10830170	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21825130	MGI
acts upstream of neuron differentiation	IDA IDA: Inferred from direct assay	10830170	MGI
involved in positive regulation of gap junction assembly	IMP IMP: Inferred from mutant phenotype	21825130	MGI
acts upstream of or within positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	10830170	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21825130	MGI
involved in proximal/distal pattern formation involved in nephron development	IEP IEP: Inferred from expression pattern	17875669	MGI
acts upstream of regulation of cell communication by electrical coupling involved in cardiac conduction	IMP IMP: Inferred from mutant phenotype	21825130	MGI
involved in specification of loop of Henle identity	IEP IEP: Inferred from expression pattern	17875669	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	19666821	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	16100003	MGI
located in nucleus	IDA IDA: Inferred from direct assay	16100003	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

iroquois-class homeodomain protein IRX-3

homeodomain protein IRXB1

iroquois homeobox protein 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06922	IRX3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20756	Irx3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27269	Irx3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Irx3	NCBI	NCBI:79191

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