NKX2-3 - NK2 homeobox 3 Gene

Homo sapiens

Also known as CSX3; NK2.3; NKX2C; NKX2.3; NKX4-3

Gene ID: 159296 | Gene type: protein coding

About NKX2-3

Cytogenetic location: 10q24.2 Genomic coordinates (GRCh38): 10:99,532,942-99,536,524 (from NCBI)

This gene has 1 transcript (splice variant), 237 orthologues and 13 paralogues. Biased expression in spleen (RPKM 11.9), small intestine (RPKM 4.8) and 5 other tissues.

Summary

This gene encodes a homeodomain-containing transcription factor. The encoded protein is a member of the NKX family of homeodomain transcription factors. Studies of similar proteins in mouse and rat have indicated a potential role in cellular differentiation.[provided by RefSeq, Mar 2010]

NKX2-3 Products(1)

mRNA	Protein	Name
NM_145285.3	NP_660328.2	homeobox protein Nkx-2.3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NKX2-3 Protein Structure

Homeobox

0
100
200
300
364 a.a.

Protein Preferred Names

Protein Names

homeobox protein Nkx-2.3

NK2 transcription factor related, locus 3

Related Diseases

Diseases

Alias

Cataract 21, Multiple Types

Cataract 21 Multiple Types	CTRCT21
Cca4	Cataract 21, Multiple Types, With Or Without Microcornea
Cataract, Pulverulent, Juvenile-Onset	Congenital Cataract Cerulean Type 4
Cataract, Congenital, Cerulean Type, 4	Cataract 21 Multiple Types With Or Without Microcornea
Cataract, Pulverulent Or Cerulean, With Or Without Microcornea	Cataract Pulverulent Juvenile-Onset
Congenital Cataract Blue Dot Type 4	Cataract, Type 21, Multiple Types

Thyroid Malformation

Inflammatory Bowel Disease 5

IBD5

Bestiality

Zoophilia

Amme Complex

Alport Syndrome, Mental Retardation, Midface Hypoplasia, And Elliptocytosis	ATS-MR
Alport Syndrome-Intellectual Disability-Midface Hypoplasia-Elliptocytosis Syndrome	Chromosome Xq22.3 Telomeric Deletion Syndrome
Amme Syndrome	Alport Syndrome With Intellectual Disability, Midface Hypoplasia And Elliptocytosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09329	NKX2-3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NKX2-3	VGNC	VGNC:53002
Rattus norvegicus	NKX2-3	RGD	RGD:1308521
Macaca mulatta	NKX2-3	VGNC	VGNC:75353
Bos taurus	NKX2-3	VGNC	VGNC:32100
Mus musculus	NKX2-3	MGD	MGI:97348

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