NKX6-3 - NK6 homeobox 3 Gene

Homo sapiens

Also known as NKX6.3

Gene ID: 157848 | Gene type: protein coding

About NKX6-3

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:41,645,177-41,650,817 (from NCBI)

This gene has 2 transcripts (splice variants), 204 orthologues and 13 paralogues. Biased expression in stomach (RPKM 15.7) and duodenum (RPKM 4.5).

Summary

The NKX family of homeodomain proteins controls numerous developmental processes. Members of the NKX6 subfamily, including NKX6-3, are involved in development of the central nervous system (CNS), gastrointestinal tract, and pancreas (Alanentalo et al., 2006 [PubMed 16326147]).[supplied by OMIM, Mar 2008]

NKX6-3 Products(2)

mRNA	Protein	Name
NM_001364841.2	NP_001351770.1	homeobox protein Nkx-6.3 isoform 1
NM_152568.3	NP_689781.1	homeobox protein Nkx-6.3 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	26314965	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	26314965	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	26314965	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	26314965	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	26314965	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NKX6-3 Protein Structure

Homeobox

0
100
200
265 a.a.

Protein Preferred Names

Protein Names

homeobox protein Nkx-6.3

NK6 transcription factor related, locus 3

Related Diseases

Diseases

Alias

Duodenal Gastrinoma

Duodenal G-Cell Gastrin Producing Tumor	Gastrinoma Of Duodenum
Malignant Duodenal Gastrinoma	Duodenal Gastrin-Producing Neuroendocrine Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09337	NKX6-3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NKX6-3	RGD	RGD:1597780
Felis catus	NKX6-3	VGNC	VGNC:63819
Bos taurus	NKX6-3	VGNC	VGNC:32108
Mus musculus	NKX6-3	MGD	MGI:1921811

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