2. Gene
  3. Hsd17b4 - hydroxysteroid (17-beta) dehydrogenase 4 Gene

Hsd17b4 - hydroxysteroid (17-beta) dehydrogenase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as DBP; MFP2; MFE-2; MPF-2; Mfp-2; perMFE-2; 17[b]-HSD; 17-beta-HSD

Gene ID: 15488 | Gene type: protein coding

About Hsd17b4

Summary

Predicted to enable hydro-lyase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and protein homodimerization activity. Acts upstream of or within Sertoli cell development; fatty acid beta-oxidation; and very long-chain fatty acid metabolic process. Located in peroxisome. Is expressed in several structures, including brain; genitourinary system; hindlimb phalanx; integumental system; and jaw. Used to study D-bifunctional protein deficiency. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Orthologous to human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4). [provided by Alliance of Genome Resources, Apr 2022]

Hsd17b4 Products(1)

mRNA Protein Name
NM_008292.4 NP_032318.2 peroxisomal multifunctional enzyme type 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within Sertoli cell development IMP
IMP: Inferred from mutant phenotype
16484321 MGI
acts upstream of or within fatty acid beta-oxidation IMP
IMP: Inferred from mutant phenotype
17442273 MGI
acts upstream of or within very long-chain fatty acid metabolic process IMP
IMP: Inferred from mutant phenotype
16484321 MGI
Cellular Component GO Annotation Evidence Reference Source
located in peroxisome IDA
IDA: Inferred from direct assay
12897163 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peroxisomal multifunctional enzyme type 2

17-beta-HSD 4

17-beta-hydroxysteroid dehydrogenase 4

D-bifunctional protein

multifunctional protein 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-120897 NS-3-008 hydrochloride Inhibitor 99.65% Unkown
HY-RS06397 HSD17B4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20632 Hsd17b4 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27141 Hsd17b4 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hsd17b4 NCBI NCBI:3295