Hmga1 - high mobility group AT-hook 1 Gene

Mus musculus

Also known as Hmgi; Hmgy; Hmgiy; Hmga1a; Hmga1b

Gene ID: 15361 | Gene type: protein coding

About Hmga1

Summary

This locus encodes a member of the nuclear, non-histone high mobility group protein family. This architectural transcription factor binds to A-T rich DNA sequences and participates in enhanceosome formation, chromatin remodeling and regulation of transcription. This protein functions in many cellular processes, including cell growth and differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

Hmga1 Products(63)

mRNA	Protein	Name
NM_001025427.3	NP_001020598.1	high mobility group protein HMG-I/HMG-Y isoform a
NM_001039356.2	NP_001034445.1	high mobility group protein HMG-I/HMG-Y isoform a
NM_001166535.1	NP_001160007.1	high mobility group protein HMG-I/HMG-Y isoform a
NM_001166536.1	NP_001160008.1	high mobility group protein HMG-I/HMG-Y isoform a
NM_001166537.1	NP_001160009.1	high mobility group protein HMG-I/HMG-Y isoform b
NM_001166539.1	NP_001160011.1	high mobility group protein HMG-I/HMG-Y isoform b
NM_001166540.1	NP_001160012.1	high mobility group protein HMG-I/HMG-Y isoform b
NM_001166541.1	NP_001160013.1	high mobility group protein HMG-I/HMG-Y isoform b
NM_001166542.1	NP_001160014.1	high mobility group protein HMG-I/HMG-Y isoform b
NM_001166543.1	NP_001160015.1	high mobility group protein HMG-I/HMG-Y isoform c
NM_001166544.1	NP_001160016.1	high mobility group protein HMG-I/HMG-Y isoform c
NM_001166545.1	NP_001160017.1	high mobility group protein HMG-I/HMG-Y isoform d
NM_001166546.1	NP_001160018.1	high mobility group protein HMG-I/HMG-Y isoform e
NM_001412718.1	NP_001399647.1	high mobility group protein HMG-I/HMG-Y
NM_001412721.1	NP_001399650.1	high mobility group protein HMG-I/HMG-Y
NM_001412722.1	NP_001399651.1	high mobility group protein HMG-I/HMG-Y
NM_001412723.1	NP_001399652.1	high mobility group protein HMG-I/HMG-Y
NM_001412724.1	NP_001399653.1	high mobility group protein HMG-I/HMG-Y
NM_001412726.1	NP_001399655.1	high mobility group protein HMG-I/HMG-Y
NM_001412727.1	NP_001399656.1	high mobility group protein HMG-I/HMG-Y
NM_001412728.1	NP_001399657.1	high mobility group protein HMG-I/HMG-Y
NM_001412729.1	NP_001399658.1	high mobility group protein HMG-I/HMG-Y
NM_001412730.1	NP_001399659.1	high mobility group protein HMG-I/HMG-Y
NM_001412731.1	NP_001399660.1	high mobility group protein HMG-I/HMG-Y
NM_001412732.1	NP_001399661.1	high mobility group protein HMG-I/HMG-Y
NM_001412733.1	NP_001399662.1	high mobility group protein HMG-I/HMG-Y
NM_001412740.1	NP_001399669.1	high mobility group protein HMG-I/HMG-Y
NM_001412748.1	NP_001399677.1	high mobility group protein HMG-I/HMG-Y
NM_001412749.1	NP_001399678.1	high mobility group protein HMG-I/HMG-Y
NM_001412750.1	NP_001399679.1	high mobility group protein HMG-I/HMG-Y
NM_001412751.1	NP_001399680.1	high mobility group protein HMG-I/HMG-Y
NM_001412752.1	NP_001399681.1	high mobility group protein HMG-I/HMG-Y
NM_001412754.1	NP_001399683.1	high mobility group protein HMG-I/HMG-Y
NM_001412755.1	NP_001399684.1	high mobility group protein HMG-I/HMG-Y
NM_001412764.1	NP_001399693.1	high mobility group protein HMG-I/HMG-Y
NM_001412765.1	NP_001399694.1	high mobility group protein HMG-I/HMG-Y
NM_001412766.1	NP_001399695.1	high mobility group protein HMG-I/HMG-Y
NM_001412767.1	NP_001399696.1	high mobility group protein HMG-I/HMG-Y
NM_001412768.1	NP_001399697.1	high mobility group protein HMG-I/HMG-Y
NM_001412769.1	NP_001399698.1	high mobility group protein HMG-I/HMG-Y
NM_001412770.1	NP_001399699.1	high mobility group protein HMG-I/HMG-Y
NM_001412771.1	NP_001399700.1	high mobility group protein HMG-I/HMG-Y
NM_001412772.1	NP_001399701.1	high mobility group protein HMG-I/HMG-Y
NM_001412773.1	NP_001399702.1	high mobility group protein HMG-I/HMG-Y
NM_001412783.1	NP_001399712.1	high mobility group protein HMG-I/HMG-Y
NM_001412943.1	NP_001399872.1	high mobility group protein HMG-I/HMG-Y
NM_001412944.1	NP_001399873.1	high mobility group protein HMG-I/HMG-Y
NM_001412945.1	NP_001399874.1	high mobility group protein HMG-I/HMG-Y
NM_001412949.1	NP_001399878.1	high mobility group protein HMG-I/HMG-Y
NM_001412950.1	NP_001399879.1	high mobility group protein HMG-I/HMG-Y
NM_001412951.1	NP_001399880.1	high mobility group protein HMG-I/HMG-Y
NM_001412952.1	NP_001399881.1	high mobility group protein HMG-I/HMG-Y
NM_001412953.1	NP_001399882.1	high mobility group protein HMG-I/HMG-Y
NM_001412954.1	NP_001399883.1	high mobility group protein HMG-I/HMG-Y
NM_001412955.1	NP_001399884.1	high mobility group protein HMG-I/HMG-Y
NM_001412956.1	NP_001399885.1	high mobility group protein HMG-I/HMG-Y
NM_001412957.1	NP_001399886.1	high mobility group protein HMG-I/HMG-Y
NM_001412958.1	NP_001399887.1	high mobility group protein HMG-I/HMG-Y
NM_001412959.1	NP_001399888.1	high mobility group protein HMG-I/HMG-Y
NM_001413142.1	NP_001400071.1	high mobility group protein HMG-I/HMG-Y
NM_001413143.1	NP_001400072.1	high mobility group protein HMG-I/HMG-Y
NM_001413144.1	NP_001400073.1	high mobility group protein HMG-I/HMG-Y
NM_016660.3	NP_057869.2	high mobility group protein HMG-I/HMG-Y isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D-loop DNA binding	IDA IDA: Inferred from direct assay	15893306	MGI
enables DNA binding	IDA IDA: Inferred from direct assay	22355763	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19389484	MGI
enables RNA polymerase II core promoter sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15713121	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	19389484	MGI
enables minor groove of adenine-thymine-rich DNA binding	IDA IDA: Inferred from direct assay	19389484	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16870469	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	19389484	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell differentiation	IDA IDA: Inferred from direct assay	32341372	MGI
acts upstream of or within T cell differentiation	IMP IMP: Inferred from mutant phenotype	15713121	MGI
acts upstream of or within autophagy	IDA IDA: Inferred from direct assay	32123163	MGI
acts upstream of or within cell population proliferation	IMP IMP: Inferred from mutant phenotype	15713121	MGI
acts upstream of or within chromatin organization	IMP IMP: Inferred from mutant phenotype	22797695	MGI
acts upstream of or within erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	15713121	MGI
acts upstream of or within gene expression	IDA IDA: Inferred from direct assay	22355763	MGI
acts upstream of or within gene expression	IGI IGI: Inferred from genetic interaction	29867121	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	15713121	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	15924147	MGI
acts upstream of or within heart development	IDA IDA: Inferred from direct assay	32123163	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	24728959	MGI
acts upstream of or within inflammatory cell apoptotic process	IDA IDA: Inferred from direct assay	32123163	MGI
acts upstream of or within inflammatory response	IDA IDA: Inferred from direct assay	32123163	MGI
acts upstream of or within insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	22355763	MGI
acts upstream of or within insulin receptor signaling pathway	IGI IGI: Inferred from genetic interaction	29867121	MGI
acts upstream of or within insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15924147	MGI
acts upstream of or within insulin secretion	IMP IMP: Inferred from mutant phenotype	15924147	MGI
acts upstream of or within lung morphogenesis	IGI IGI: Inferred from genetic interaction	31582725	MGI
acts upstream of or within lymphoid progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	15713121	MGI
acts upstream of or within multicellular organism growth	IGI IGI: Inferred from genetic interaction	24728959	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	22207709	MGI
acts upstream of or within neurogenesis	IMP IMP: Inferred from mutant phenotype	22797695	MGI
acts upstream of or within peroxisome proliferator activated receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22207709	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19389484	MGI
acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	19460132	MGI
acts upstream of or within respiratory system process	IGI IGI: Inferred from genetic interaction	31582725	MGI
acts upstream of or within response to cAMP	IMP IMP: Inferred from mutant phenotype	19460132	MGI
acts upstream of or within response to glucagon	IMP IMP: Inferred from mutant phenotype	19460132	MGI
acts upstream of or within response to glucose	IDA IDA: Inferred from direct assay	32123163	MGI
acts upstream of or within response to insulin	IDA IDA: Inferred from direct assay	22355763	MGI
acts upstream of or within response to insulin	IGI IGI: Inferred from genetic interaction	29867121	MGI
acts upstream of or within response to insulin	IMP IMP: Inferred from mutant phenotype	15924147	MGI
acts upstream of or within response to wounding	IMP IMP: Inferred from mutant phenotype	22207709	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	12874803	MGI
acts upstream of or within thyroid gland development	IGI IGI: Inferred from genetic interaction	31582725	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	19389484	MGI
part of SUMO ligase complex	IDA IDA: Inferred from direct assay	22207709	MGI
is active in cytoplasm	IDA IDA: Inferred from direct assay	15893306	MGI
located in male germ cell nucleus	IDA IDA: Inferred from direct assay	12032866	MGI
is active in mitochondrion	IDA IDA: Inferred from direct assay	15893306	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	15893306	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12032866	MGI
is active in nucleus	IPI IPI: Inferred from physical interaction	16870469	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

high mobility group protein HMG-I/HMG-Y

high mobility group AT-hook protein 1	high mobility group protein A1
high mobility group protein I

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06230	HMGA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17912	Hmga1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24381	Hmga1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hmga1	NCBI	NCBI:3159

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