Gata4 - GATA binding protein 4 Gene

Mus musculus

Also known as Gata-4

Gene ID: 14463 | Gene type: protein coding

About Gata4

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including heart development; negative regulation of cell death; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and regulation of gene expression. Located in chromatin and nucleus. Is expressed in several structures, including early conceptus; embryo mesenchyme; gut; heart; and reproductive system. Used to study atrial heart septal defect 2 and congenital diaphragmatic hernia. Human ortholog(s) of this gene implicated in congenital heart disease (multiple). Orthologous to human GATA4 (GATA binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Gata4 Products(4)

mRNA	Protein	Name
NM_001310610.1	NP_001297539.1	transcription factor GATA-4 isoform 1
NM_008092.4	NP_032118.2	transcription factor GATA-4 isoform 2
NM_001310610.1	NP_001297539.1	transcription factor GATA-4 isoform 1
NM_008092.4	NP_032118.2	transcription factor GATA-4 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	8007990	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	9738004	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12845333	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15539431	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16603706	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	21379568	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9584153	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8455608	MGI
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	11724781	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Sertoli cell differentiation	IMP IMP: Inferred from mutant phenotype	21172404	MGI
involved in atrial septum primum morphogenesis	IMP IMP: Inferred from mutant phenotype	17643447	MGI
involved in atrioventricular canal development	IGI IGI: Inferred from genetic interaction	21330551	MGI
involved in atrioventricular valve formation	IGI IGI: Inferred from genetic interaction	21330551	MGI
acts upstream of or within atrioventricular valve morphogenesis	IGI IGI: Inferred from genetic interaction	19084512	MGI
acts upstream of or within cardiac muscle cell differentiation	IGI IGI: Inferred from genetic interaction	18400219	MGI
acts upstream of or within cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	18400219	MGI
acts upstream of cardiac muscle cell proliferation	IGI IGI: Inferred from genetic interaction	19084512	MGI
acts upstream of or within cardiac muscle hypertrophy in response to stress	IMP IMP: Inferred from mutant phenotype	20705924	MGI
acts upstream of or within cardiac muscle tissue development	IGI IGI: Inferred from genetic interaction	20705924	MGI
involved in cardiac muscle tissue regeneration	IDA IDA: Inferred from direct assay	25590961	MGI
involved in cardiac right ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	17643447	MGI
involved in cardiac septum development	IGI IGI: Inferred from genetic interaction	21330551	MGI
acts upstream of or within cell-cell signaling	IMP IMP: Inferred from mutant phenotype	16127717	MGI
acts upstream of or within cellular response to follicle-stimulating hormone stimulus	IDA IDA: Inferred from direct assay	9231805	MGI
acts upstream of or within cellular response to gonadotropin stimulus	IDA IDA: Inferred from direct assay	9231805	MGI
acts upstream of or within embryonic digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	16127717	MGI
acts upstream of or within embryonic foregut morphogenesis	IMP IMP: Inferred from mutant phenotype	9136932	MGI
acts upstream of or within embryonic heart tube anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	9136932	MGI
acts upstream of or within embryonic heart tube development	IMP IMP: Inferred from mutant phenotype	9136932	MGI
acts upstream of or within embryonic morphogenesis	IMP IMP: Inferred from mutant phenotype	9136932	MGI
acts upstream of or within endocardial cushion development	IGI IGI: Inferred from genetic interaction	19084512	MGI
involved in endocardial cushion development	IMP IMP: Inferred from mutant phenotype	17643447	MGI
acts upstream of or within endoderm formation	IMP IMP: Inferred from mutant phenotype	8582296	MGI
acts upstream of or within epithelial cell fate commitment	IMP IMP: Inferred from mutant phenotype	16940177	MGI
acts upstream of or within gastrulation with mouth forming second	IMP IMP: Inferred from mutant phenotype	9136933	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	11297508	MGI
involved in heart looping	IMP IMP: Inferred from mutant phenotype	15310850	MGI
involved in heart morphogenesis	IMP IMP: Inferred from mutant phenotype	17975667	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	9136932	MGI
acts upstream of or within lung lobe formation	IMP IMP: Inferred from mutant phenotype	17142311	MGI
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	23558708	MGI
involved in negative regulation of apoptotic signaling pathway	IDA IDA: Inferred from direct assay	25590961	MGI
involved in negative regulation of cardiac muscle cell apoptotic process	IGI IGI: Inferred from genetic interaction	25590961	MGI
involved in negative regulation of connective tissue replacement	IDA IDA: Inferred from direct assay	25590961	MGI
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	25590961	MGI
acts upstream of negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	25590961	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14978031	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12845333	MGI
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	17975667	MGI
acts upstream of or within positive regulation of cardiac muscle cell proliferation	IGI IGI: Inferred from genetic interaction	19084512	MGI
involved in positive regulation of cell cycle	IDA IDA: Inferred from direct assay	23558708	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	23558708	MGI
involved in positive regulation of miRNA transcription	IDA IDA: Inferred from direct assay	25590961	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8007990	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12845333	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15539431	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17272516	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21220346	MGI
involved in positive regulation of vascular endothelial growth factor production	IDA IDA: Inferred from direct assay	17975667	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9738004	MGI
acts upstream of or within regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	15902305	MGI
acts upstream of or within regulation of gene expression	IDA IDA: Inferred from direct assay	20833366	MGI
acts upstream of or within regulation of gene expression	IGI IGI: Inferred from genetic interaction	18400219	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8007990	MGI
acts upstream of or within response to estrogen	IDA IDA: Inferred from direct assay	9231805	MGI
involved in response to retinoic acid	IDA IDA: Inferred from direct assay	18439490	MGI
acts upstream of or within seminiferous tubule development	IMP IMP: Inferred from mutant phenotype	21172404	MGI
acts upstream of or within signal transduction involved in regulation of gene expression	IDA IDA: Inferred from direct assay	18462699	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	21172404	MGI
acts upstream of or within tube morphogenesis	IGI IGI: Inferred from genetic interaction	18400219	MGI
acts upstream of or within ventricular cardiac muscle tissue development	IGI IGI: Inferred from genetic interaction	19084512	MGI
involved in ventricular septum development	IMP IMP: Inferred from mutant phenotype	17643447	MGI
involved in wound healing	IDA IDA: Inferred from direct assay	25590961	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	21029371	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12801993	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor GATA-4

GATA-binding factor 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103484	GATA4-NKX2-5-IN-1	Inhibitor	99.24%	Unkown
HY-128326	ZAK-IN-1	Inhibitor	/	Unkown
HY-RS05292	GATA4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174481	Mouse Gata4 mRNA		/	Unkown
HY-RS18176	Gata4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24650	Gata4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gata4	NCBI	NCBI:2626

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