Fzd4 - frizzled class receptor 4 Gene

Mus musculus

Also known as Fz4

Gene ID: 14366 | Gene type: protein coding

About Fzd4

Summary

Enables Wnt-activated receptor activity; Wnt-protein binding activity; and cytokine binding activity. Involved in several processes, including cell surface receptor signaling pathway involved in cell-cell signaling; regulation of transcription, DNA-templated; and vasculature development. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of signal transduction; and vasculature development. Located in several cellular components, including cell-cell junction; dendrite; and glutamatergic synapse. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Used to study Norrie disease and exudative vitreoretinopathy. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 1. Orthologous to human FZD4 (Frizzled class receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Fzd4 Products(1)

mRNA	Protein	Name
NM_008055.4	NP_032081.3	frizzled-4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Wnt receptor activity	IPI IPI: Inferred from physical interaction	16163358	MGI
enables Wnt-protein binding	IPI IPI: Inferred from physical interaction	12490564	MGI
enables cytokine binding	IPI IPI: Inferred from physical interaction	15035989	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15195140	MGI
enables signaling receptor activity	IGI IGI: Inferred from genetic interaction	25424568	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in Norrin signaling pathway	IDA IDA: Inferred from direct assay	15035989	MGI
involved in Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	25424568	MGI
acts upstream of or within angiogenesis	IGI IGI: Inferred from genetic interaction	27823583	MGI
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	27823583	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	19837032	MGI
acts upstream of or within canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	16115200	MGI
involved in canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	19001373	MGI
acts upstream of or within cell population proliferation	IMP IMP: Inferred from mutant phenotype	25414188	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
involved in cerebellum vasculature morphogenesis	IMP IMP: Inferred from mutant phenotype	15035989	MGI
acts upstream of or within endothelial cell differentiation	IMP IMP: Inferred from mutant phenotype	23217714	MGI
acts upstream of or within establishment of blood-brain barrier	IGI IGI: Inferred from genetic interaction	30478038	MGI
acts upstream of or within establishment of blood-brain barrier	IMP IMP: Inferred from mutant phenotype	23217714	MGI
involved in extracellular matrix-cell signaling	IDA IDA: Inferred from direct assay	15035989	MGI
acts upstream of or within locomotion involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	11425903	MGI
acts upstream of or within luteinization	IMP IMP: Inferred from mutant phenotype	16093361	MGI
involved in negative regulation of cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	18156211	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15035989	MGI
acts upstream of or within positive regulation of JUN kinase activity	IGI IGI: Inferred from genetic interaction	15195140	MGI
involved in positive regulation of neuron projection arborization	IGI IGI: Inferred from genetic interaction	25424568	MGI
acts upstream of or within progesterone secretion	IMP IMP: Inferred from mutant phenotype	16093361	MGI
acts upstream of or within regulation of vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16093361	MGI
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	25414188	MGI
acts upstream of or within retina vasculature development in camera-type eye	IMP IMP: Inferred from mutant phenotype	23217714	MGI
acts upstream of or within retina vasculature morphogenesis in camera-type eye	IGI IGI: Inferred from genetic interaction	19837032	MGI
acts upstream of or within retina vasculature morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	19837032	MGI
involved in retinal blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	15035989	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	11425903	MGI
acts upstream of or within substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	18156211	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	16093361	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	15195140	MGI
located in dendrite	IMP IMP: Inferred from mutant phenotype	25424568	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16501258	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15035989	MGI
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	18156211	MGI
is active in synapse	IDA IDA: Inferred from direct assay	16501258	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

frizzled-4

frizzled homolog 4	fz-4
mFz4

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117163	FzM1.8	Agonist	98.93%	Unkown
HY-116553	FzM1	Inhibitor	98.62%	Unkown
HY-RS05180	FZD4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17330	Fzd4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23785	Fzd4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fzd4	NCBI	NCBI:8322
Rattus norvegicus	Fzd4	NCBI	NCBI:64558

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