Foxc2 - forkhead box C2 Gene

Mus musculus

Also known as Mfh1; Fkh14; MFH-1; Hfhbf3

Gene ID: 14234 | Gene type: protein coding

About Foxc2

Summary

Enables several functions, including DNA-binding transcription activator activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and promoter-specific chromatin binding activity. Involved in several processes, including positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of vascular wound healing; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and vasculature development. Predicted to be located in nuclear body. Is expressed in several structures, including cardiovascular system; central nervous system; embryo mesenchyme; limb long bone; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including lymphedema; lymphedema-distichiasis syndrome; obesity; ptosis; and type 2 diabetes mellitus. Orthologous to human FOXC2 (forkhead box C2). [provided by Alliance of Genome Resources, Apr 2022]

Foxc2 Products(1)

mRNA	Protein	Name
NM_013519.2	NP_038547.2	forkhead box protein C2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	8325367	MGI
enables DNA-binding transcription activator activity	IDA IDA: Inferred from direct assay	9169153	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	18579532	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	18187037	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IGI IGI: Inferred from genetic interaction	16678147	MGI
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	18187037	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18579532	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Notch signaling pathway	IGI IGI: Inferred from genetic interaction	11562355	MGI
acts upstream of apoptotic process involved in outflow tract morphogenesis	IGI IGI: Inferred from genetic interaction	16839542	MGI
acts upstream of or within artery morphogenesis	IMP IMP: Inferred from mutant phenotype	9409679	MGI
acts upstream of or within blood vessel development	IGI IGI: Inferred from genetic interaction	16678147	MGI
acts upstream of or within blood vessel diameter maintenance	IGI IGI: Inferred from genetic interaction	16678147	MGI
acts upstream of or within blood vessel remodeling	IGI IGI: Inferred from genetic interaction	11562355	MGI
acts upstream of or within branching involved in blood vessel morphogenesis	IGI IGI: Inferred from genetic interaction	15664398	MGI
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	10767326	MGI
acts upstream of or within cardiac muscle cell proliferation	IGI IGI: Inferred from genetic interaction	16839542	MGI
acts upstream of or within cell population proliferation	IMP IMP: Inferred from mutant phenotype	9106663	MGI
acts upstream of or within collagen fibril organization	IMP IMP: Inferred from mutant phenotype	10767326	MGI
acts upstream of or within embryonic cranial skeleton morphogenesis	IMP IMP: Inferred from mutant phenotype	9106663	MGI
acts upstream of or within embryonic heart tube development	IGI IGI: Inferred from genetic interaction	16678147	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	9409679	MGI
acts upstream of or within embryonic viscerocranium morphogenesis	IMP IMP: Inferred from mutant phenotype	9409679	MGI
acts upstream of or within glomerular endothelium development	IMP IMP: Inferred from mutant phenotype	16498405	MGI
acts upstream of or within glomerular mesangial cell development	IMP IMP: Inferred from mutant phenotype	16498405	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	15664398	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	10479458	MGI
acts upstream of or within heart morphogenesis	IGI IGI: Inferred from genetic interaction	16839542	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	10704385	MGI
acts upstream of or within lymph vessel development	IGI IGI: Inferred from genetic interaction	16678147	MGI
acts upstream of or within metanephros development	IMP IMP: Inferred from mutant phenotype	16498405	MGI
acts upstream of or within negative regulation of apoptotic process involved in outflow tract morphogenesis	IGI IGI: Inferred from genetic interaction	16839542	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18579532	MGI
acts upstream of or within neural crest cell development	IGI IGI: Inferred from genetic interaction	16839542	MGI
acts upstream of or within ossification	IMP IMP: Inferred from mutant phenotype	9106663	MGI
acts upstream of or within paraxial mesoderm formation	IGI IGI: Inferred from genetic interaction	11562355	MGI
acts upstream of or within paraxial mesodermal cell fate commitment	IMP IMP: Inferred from mutant phenotype	9106663	MGI
acts upstream of or within podocyte differentiation	IMP IMP: Inferred from mutant phenotype	16498405	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9169153	MGI
involved in positive regulation of cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	18579532	MGI
involved in positive regulation of cell migration involved in sprouting angiogenesis	IDA IDA: Inferred from direct assay	18579532	MGI
involved in positive regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	18579532	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16678147	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18579532	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18187037	MGI
involved in positive regulation of vascular wound healing	IDA IDA: Inferred from direct assay	18579532	MGI
acts upstream of or within regulation of organ growth	IGI IGI: Inferred from genetic interaction	16839542	MGI
acts upstream of or within skeletal system development	IGI IGI: Inferred from genetic interaction	10364424	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	10364424	MGI
involved in somitogenesis	IGI IGI: Inferred from genetic interaction	11562355	MGI
acts upstream of or within ureteric bud development	IMP IMP: Inferred from mutant phenotype	10704385	MGI
acts upstream of or within vascular endothelial growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	16678147	MGI
acts upstream of or within ventricular cardiac muscle tissue morphogenesis	IGI IGI: Inferred from genetic interaction	16839542	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

forkhead box protein C2

BF-3	brain factor 3
forkhead homolog 14	forkhead-related protein FKHL14
mesenchyme fork head protein 1	transcription factor FKH-14

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-149894	MC-1-F2		99.78%	Unkown
HY-RS05042	FOXC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22513	Foxc2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Foxc2	NCBI	NCBI:2303

Name
Email *

	Sorry, but the email address you supplied was invalid.