Sh3pxd2a - SH3 and PX domains 2A Gene

Mus musculus

Also known as Fish; TSK5; Tks5; Gm5098; Sh3md1; EG329070; C230050L11; 2310014D11Rik

Gene ID: 14218 | Gene type: protein coding

About Sh3pxd2a

Summary

Enables phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and protease binding activity. Involved in Reactive Oxygen Species metabolic process. Acts upstream of or within in utero embryonic development. Located in cytoplasm and podosome. Is expressed in several structures, including brain; clavicle; liver; skeletal muscle; and spleen. Orthologous to human SH3PXD2A (SH3 and PX domains 2A). [provided by Alliance of Genome Resources, Apr 2022]

Sh3pxd2a Products(2)

mRNA	Protein	Name
NM_001164717.1	NP_001158189.1	SH3 and PX domain-containing protein 2A isoform 2
NM_008018.4	NP_032044.2	SH3 and PX domain-containing protein 2A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidylinositol binding	IMP IMP: Inferred from mutant phenotype	12615925	MGI
enables phosphatidylinositol-3,4-bisphosphate binding	IMP IMP: Inferred from mutant phenotype	12615925	MGI
enables phosphatidylinositol-3-phosphate binding	IMP IMP: Inferred from mutant phenotype	12615925	MGI
enables phosphatidylinositol-4,5-bisphosphate binding	IMP IMP: Inferred from mutant phenotype	12615925	MGI
enables phosphatidylinositol-4-phosphate binding	IMP IMP: Inferred from mutant phenotype	12615925	MGI
enables phosphatidylinositol-5-phosphate binding	IMP IMP: Inferred from mutant phenotype	12615925	MGI
enables protease binding	IPI IPI: Inferred from physical interaction	12615925	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19755709	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	27996060	MGI
involved in reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	19755709	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12615925	MGI
located in podosome	IDA IDA: Inferred from direct assay	12615925	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

SH3 and PX domain-containing protein 2A

SH3 multiple domains 1	SH3 multiple domains protein 1
five SH3 domain-containing protein	five SH3 domains
tyrosine kinase substrate with five SH3 domains

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12842	SH3PXD2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22070	Sh3pxd2a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sh3pxd2a	NCBI	NCBI:9644

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