Ercc2 - excision repair cross-complementing rodent repair deficiency, complementation group 2 Gene

Mus musculus

Also known as XPD; CXPD; Ercc-2; RCO015; Mhdarco15

Gene ID: 13871 | Gene type: protein coding

About Ercc2

Summary

Predicted to enable several functions, including 5'-3' DNA helicase activity; protein C-terminus binding activity; and protein N-terminus binding activity. Acts upstream of or within several processes, including animal organ development; neurogenesis; and nucleic acid metabolic process. Located in nucleus. Is expressed in central nervous system; eye; hair follicle; and liver. Used to study photosensitive trichothiodystrophy and xeroderma pigmentosum group D. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; acquired immunodeficiency syndrome; carcinoma (multiple); hematologic Cancer (multiple); and xeroderma pigmentosum (multiple). Orthologous to human ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit). [provided by Alliance of Genome Resources, Apr 2022]

Ercc2 Products(2)

mRNA	Protein	Name
NM_001363981.1	NP_001350910.1	general transcription and DNA repair factor IIH helicase subunit XPD isoform 2
NM_007949.5	NP_031975.2	general transcription and DNA repair factor IIH helicase subunit XPD isoform 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA repair	IMP IMP: Inferred from mutant phenotype	11950998	MGI
acts upstream of or within UV protection	IMP IMP: Inferred from mutant phenotype	9651581	MGI
acts upstream of or within bone mineralization	IMP IMP: Inferred from mutant phenotype	17020410	MGI
acts upstream of or within central nervous system myelin formation	IMP IMP: Inferred from mutant phenotype	17952069	MGI
acts upstream of or within determination of adult lifespan	IMP IMP: Inferred from mutant phenotype	11950998	MGI
acts upstream of or within embryonic cleavage	IMP IMP: Inferred from mutant phenotype	9426063	MGI
acts upstream of or within erythrocyte maturation	IMP IMP: Inferred from mutant phenotype	17020410	MGI
acts upstream of or within extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	9651581	MGI
acts upstream of or within hair cell differentiation	IMP IMP: Inferred from mutant phenotype	17020410	MGI
acts upstream of or within hair cycle process	IMP IMP: Inferred from mutant phenotype	17020410	MGI
acts upstream of or within hair follicle maturation	IMP IMP: Inferred from mutant phenotype	9651581	MGI
acts upstream of or within hematopoietic stem cell differentiation	IMP IMP: Inferred from mutant phenotype	17554309	MGI
acts upstream of or within hematopoietic stem cell proliferation	IMP IMP: Inferred from mutant phenotype	17554309	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	17020410	MGI
acts upstream of or within insulin-like growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18545656	MGI
acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator	IMP IMP: Inferred from mutant phenotype	18545656	MGI
acts upstream of or within maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP IMP: Inferred from mutant phenotype	23562818	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	17020410	MGI
acts upstream of or within nucleotide-excision repair	IMP IMP: Inferred from mutant phenotype	9651581	MGI
acts upstream of or within positive regulation of DNA binding	IMP IMP: Inferred from mutant phenotype	17952069	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	11950998	MGI
acts upstream of or within response to UV	IMP IMP: Inferred from mutant phenotype	17020410	MGI
acts upstream of or within response to oxidative stress	IMP IMP: Inferred from mutant phenotype	11950998	MGI
acts upstream of or within ribosomal small subunit biogenesis	IMP IMP: Inferred from mutant phenotype	23562818	MGI
acts upstream of or within skin development	IMP IMP: Inferred from mutant phenotype	9651581	MGI
acts upstream of or within spinal cord development	IMP IMP: Inferred from mutant phenotype	17020410	MGI
acts upstream of or within transcription elongation by RNA polymerase I	IMP IMP: Inferred from mutant phenotype	23562818	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	17952069	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

general transcription and DNA repair factor IIH helicase subunit XPD

DNA excision repair protein ERCC-2	DNA repair protein complementing XP-D cells
TFIIH basal transcription factor complex helicase XPD subunit	xeroderma pigmentosum group D-complementing protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04479	ERCC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22491	Ercc2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29014	Ercc2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ercc2	NCBI	NCBI:2068

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