2. Gene
  3. LETM2 - leucine zipper and EF-hand containing transmembrane protein 2 Gene

LETM2 - leucine zipper and EF-hand containing transmembrane protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SLC55A2

Gene ID: 137994 | Gene type: protein coding

About LETM2

This gene has 15 transcripts (splice variants), 214 orthologues and 2 paralogues. Broad expression in testis (RPKM 3.0), brain (RPKM 0.6) and 14 other tissues.

Summary

Predicted to enable ribosome binding activity. Predicted to be involved in cellular metal ion homeostasis. Predicted to be located in mitochondrial inner membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

LETM2 Products(9)

mRNA Protein Name
NM_001199659.3 NP_001186588.1 LETM1 domain-containing protein LETM2, mitochondrial isoform 1
NM_001199660.3 NP_001186589.1 LETM1 domain-containing protein LETM2, mitochondrial isoform 3
NM_001286787.2 NP_001273716.1 LETM1 domain-containing protein LETM2, mitochondrial isoform 3
NM_001286819.2 NP_001273748.1 LETM1 domain-containing protein LETM2, mitochondrial isoform 4
NM_001286821.2 NP_001273750.1 LETM1 domain-containing protein LETM2, mitochondrial isoform 5
NM_001330515.2 NP_001317444.1 LETM1 domain-containing protein LETM2, mitochondrial isoform 6
NM_001363204.1 NP_001350133.1 LETM1 domain-containing protein LETM2, mitochondrial isoform 7 precursor
NM_001363205.1 NP_001350134.1 LETM1 domain-containing protein LETM2, mitochondrial isoform 3
NM_144652.4 NP_653253.1 LETM1 domain-containing protein LETM2, mitochondrial isoform 2

LETM2 Protein Structure

LETM1

LETM1: LETM1-like protein (120 - 386)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 491 a.a.
Protein Preferred Names Protein Names

LETM1 domain-containing protein LETM2, mitochondrial

LETM1 and EF-hand domain-containing protein 2

Related Diseases

Diseases Alias
Acute Hemorrhagic Leukoencephalitis

Ahl

Acute Haemorrhagic Leucoencephalitis Of Weston Hurst

Leukoencephalitis, Acute Hemorrhagic

Acute Hemorrhagic Encephalomyelitis

Acute Necrotizing Hemorrhagic Leukoencephalitis

Weston-Hurst Syndrome

Ahle

Acute Haemorrhagic Leucoencephalitis

Hurst Disease

Acute Haemorrhagic Leukoencephalitis, Postimmunization Or Postvaccinal

Postimmunization Or Postvaccinal Leukoencephalopathy
Wolf-Hirschhorn Syndrome

Pitt-Rogers-Danks Syndrome

WHS

Chromosome 4p16.3 Deletion Syndrome

Wittwer Syndrome

4p- Syndrome

Pitt Syndrome

4p Deletion Syndrome

Distal Deletion 4p

Distal Monosomy 4p

Telomeric Deletion 4p

Prds

4p Syndrome

Chromosome 4p Syndrome

Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation

Wolf Syndrome

Chromosome 4p Deletion Syndrome

Chromosome 4p Monosomy

Del Syndrome

Monosomy 4p

Partial Monosomy 4p

Chromosome 4 Short Arm Deletion
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07598 LETM2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LETM2 MGD MGI:2444979
Canis familiaris LETM2 VGNC VGNC:42642
Macaca mulatta LETM2 VGNC VGNC:74046
Rattus norvegicus LETM2 RGD RGD:1311220
Felis catus LETM2 VGNC VGNC:63215