2. Gene
  3. Degs1 - delta(4)-desaturase, sphingolipid 1 Gene

Degs1 - delta(4)-desaturase, sphingolipid 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Degs; Des1; Mdes

Gene ID: 13244 | Gene type: protein coding

About Degs1

Summary

Enables retinol isomerase activity and sphingolipid delta-4 desaturase activity. Acts upstream of or within ceramide biosynthetic process and positive regulation of apoptotic process. Predicted to be located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human DEGS1 (delta 4-desaturase, sphingolipid 1). [provided by Alliance of Genome Resources, Apr 2022]

Degs1 Products(2)

mRNA Protein Name
NM_001360783.1 NP_001347712.1 sphingolipid delta(4)-desaturase DES1 isoform 2
NM_007853.5 NP_031879.1 sphingolipid delta(4)-desaturase DES1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables retinol isomerase activity IDA
IDA: Inferred from direct assay
23143414 MGI
enables sphingolipid delta-4 desaturase activity IMP
IMP: Inferred from mutant phenotype
22984457 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within ceramide biosynthetic process IMP
IMP: Inferred from mutant phenotype
22984457 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
22984457 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sphingolipid delta(4)-desaturase DES1

degenerative spermatocyte homolog 1

dihydroceramide desaturase

dihydroceramide desaturase-1

retinol isomerase

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-153665 Deg-1 99.45% Unkown
HY-RS03682 DEGS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21551 Degs1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28069 Degs1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Degs1 NCBI NCBI:8560