Dab2 - disabled 2, mitogen-responsive phosphoprotein Gene

Mus musculus

Also known as p96; Doc2; Doc-2; D15Wsu122e; 5730435J12Rik; D630005B22Rik

Gene ID: 13132 | Gene type: protein coding

About Dab2

Summary

Enables several functions, including AP-2 adaptor complex binding activity; clathrin adaptor activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Acts upstream of or within several processes, including endocytosis; hemopoiesis; and negative regulation of extrinsic apoptotic signaling pathway. Located in apical plasma membrane; cytoplasm; and nucleus. Part of clathrin coat of coated pit. Is expressed in several structures, including central nervous system; egg cylinder; embryo mesenchyme; future hindbrain roof plate; and metanephros. Orthologous to human DAB2 (DAB adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Dab2 Products(5)

mRNA	Protein	Name
NM_001008702.2	NP_001008702.1	disabled homolog 2 isoform b
NM_001037905.3	NP_001032994.1	disabled homolog 2 isoform b
NM_001102400.1	NP_001095870.1	disabled homolog 2 isoform c
NM_001310446.1	NP_001297375.1	disabled homolog 2 isoform d
NM_023118.5	NP_075607.2	disabled homolog 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables AP-2 adaptor complex binding	IDA IDA: Inferred from direct assay	12234931	MGI
enables cargo receptor activity	IDA IDA: Inferred from direct assay	16984970	MGI
enables clathrin adaptor activity	IDA IDA: Inferred from direct assay	16984970	MGI
enables clathrin binding	IDA IDA: Inferred from direct assay	12234931	MGI
enables integrin binding	IMP IMP: Inferred from mutant phenotype	15734730	MGI
enables phosphatidylinositol binding	IDA IDA: Inferred from direct assay	12234931	MGI
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	12826668	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9569023	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	12413896	MGI
involved in cellular response to transforming growth factor beta stimulus	IDA IDA: Inferred from direct assay	15734730	MGI
involved in clathrin coat assembly	IDA IDA: Inferred from direct assay	12234931	MGI
acts upstream of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	15734730	MGI
acts upstream of or within hematopoietic stem cell proliferation	IDA IDA: Inferred from direct assay	29925839	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	12413896	MGI
involved in myeloid cell differentiation	IEP IEP: Inferred from expression pattern	11823414	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15734730	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	15734730	MGI
involved in negative regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	19581412	MGI
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	15894542	MGI
involved in positive regulation of cell adhesion	IDA IDA: Inferred from direct assay	11823414	MGI
involved in positive regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	15734730	MGI
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	15894542	MGI
involved in positive regulation of clathrin-dependent endocytosis	IDA IDA: Inferred from direct assay	16984970	MGI
involved in positive regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	15734730	MGI
involved in positive regulation of integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	15734730	MGI
involved in positive regulation of receptor internalization	IMP IMP: Inferred from mutant phenotype	23354168	MGI
involved in positive regulation of receptor recycling	IMP IMP: Inferred from mutant phenotype	20881059	MGI
involved in positive regulation of substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	11823414	MGI
involved in positive regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	15734730	MGI
involved in positive regulation of transcription elongation by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15894542	MGI
acts upstream of or within receptor-mediated endocytosis	IPI IPI: Inferred from physical interaction	12413896	MGI
acts upstream of or within renal protein absorption	IMP IMP: Inferred from mutant phenotype	11927540	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	21146513	MGI
part of clathrin coat of coated pit	IDA IDA: Inferred from direct assay	11247302	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	21146513	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

disabled homolog 2

adaptor molecule disabled-2	differentially expressed in ovarian carcinoma 2
mitogen-responsive phosphoprotein

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03511	DAB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-112114	DTPA-DAB2		/	Unkown
HY-RS03512	DAB2IP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20265	Dab2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26773	Dab2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dab2	NCBI	NCBI:1601

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