Col6a1 - collagen, type VI, alpha 1 Gene

Mus musculus

Also known as Col6a-1

Gene ID: 12833 | Gene type: protein coding

About Col6a1

Summary

Predicted to enable Collagen binding activity and platelet-derived growth factor binding activity. Acts upstream of or within cellular response to amino acid stimulus. Located in extracellular matrix and sarcolemma. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart and pericardium; and sensory organ. Used to study Bethlem myopathy and Ullrich congenital muscular dystrophy. Human ortholog(s) of this gene implicated in Ullrich congenital muscular dystrophy. Orthologous to human COL6A1 (Collagen type VI alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2022]

Col6a1 Products(1)

mRNA	Protein	Name
NM_009933.4	NP_034063.1	collagen alpha-1(VI) chain precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23300779	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within 2-oxoglutarate metabolic process	IMP IMP: Inferred from mutant phenotype	23437220	MGI
acts upstream of or within adipose tissue development	IMP IMP: Inferred from mutant phenotype	19114551	MGI
acts upstream of or within apoptotic nuclear changes	IMP IMP: Inferred from mutant phenotype	14625552	MGI
acts upstream of or within apoptotic process	IGI IGI: Inferred from genetic interaction	19293339	MGI
acts upstream of or within apoptotic process	IMP IMP: Inferred from mutant phenotype	14625552	MGI
acts upstream of or within autophagy	IMP IMP: Inferred from mutant phenotype	21037586	MGI
acts upstream of or within basement membrane organization	IMP IMP: Inferred from mutant phenotype	25158062	MGI
acts upstream of or within bone development	IMP IMP: Inferred from mutant phenotype	22448243	MGI
acts upstream of or within bone mineralization	IMP IMP: Inferred from mutant phenotype	19248115	MGI
acts upstream of or within canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	25989472	MGI
acts upstream of or within cartilage development	IMP IMP: Inferred from mutant phenotype	19248115	MGI
acts upstream of or within caveola assembly	IMP IMP: Inferred from mutant phenotype	19114551	MGI
acts upstream of or within cell death	IMP IMP: Inferred from mutant phenotype	28043812	MGI
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	24302007	MGI
acts upstream of or within cellular response to amino acid stimulus	IDA IDA: Inferred from direct assay	20548288	MGI
acts upstream of or within circadian rhythm	IMP IMP: Inferred from mutant phenotype	26945058	MGI
acts upstream of or within collagen fibril organization	IGI IGI: Inferred from genetic interaction	28604699	MGI
acts upstream of or within collagen fibril organization	IMP IMP: Inferred from mutant phenotype	25158062	MGI
acts upstream of or within collagen metabolic process	IMP IMP: Inferred from mutant phenotype	22343710	MGI
acts upstream of or within energy homeostasis	IMP IMP: Inferred from mutant phenotype	19114551	MGI
acts upstream of or within energy reserve metabolic process	IMP IMP: Inferred from mutant phenotype	23437220	MGI
acts upstream of or within extracellular matrix assembly	IMP IMP: Inferred from mutant phenotype	19114551	MGI
acts upstream of or within fat cell proliferation	IMP IMP: Inferred from mutant phenotype	19114551	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	19114551	MGI
acts upstream of or within glycolytic process	IMP IMP: Inferred from mutant phenotype	23437220	MGI
acts upstream of or within hair follicle development	IDA IDA: Inferred from direct assay	25989472	MGI
acts upstream of or within hair follicle development	IMP IMP: Inferred from mutant phenotype	25989472	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	22343710	MGI
acts upstream of or within homeostasis of number of cells	IMP IMP: Inferred from mutant phenotype	28043812	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	19114551	MGI
acts upstream of or within insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19114551	MGI
acts upstream of or within insulin-like growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28043812	MGI
acts upstream of or within limb joint morphogenesis	IMP IMP: Inferred from mutant phenotype	22448243	MGI
acts upstream of or within lung alveolus development	IMP IMP: Inferred from mutant phenotype	31837950	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	24357721	MGI
acts upstream of or within lung epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	31837950	MGI
acts upstream of or within lung morphogenesis	IMP IMP: Inferred from mutant phenotype	31837950	MGI
acts upstream of or within metabolic process	IMP IMP: Inferred from mutant phenotype	23437220	MGI
acts upstream of or within mitochondrial depolarization	IGI IGI: Inferred from genetic interaction	19293339	MGI
acts upstream of or within mitochondrial depolarization	IMP IMP: Inferred from mutant phenotype	19519726	MGI
acts upstream of or within mitochondrial transmembrane transport	IMP IMP: Inferred from mutant phenotype	19519726	MGI
acts upstream of or within mitochondrion organization	IGI IGI: Inferred from genetic interaction	19293339	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	14625552	MGI
acts upstream of or within multicellular organismal locomotion	IMP IMP: Inferred from mutant phenotype	19114551	MGI
acts upstream of or within muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19519726	MGI
acts upstream of or within muscle cell development	IMP IMP: Inferred from mutant phenotype	20716577	MGI
acts upstream of or within muscle organ development	IMP IMP: Inferred from mutant phenotype	26945058	MGI
acts upstream of or within muscle structure development	IGI IGI: Inferred from genetic interaction	19293339	MGI
acts upstream of or within muscle system process	IMP IMP: Inferred from mutant phenotype	24852368	MGI
acts upstream of or within myelination in peripheral nervous system	IMP IMP: Inferred from mutant phenotype	24277578	MGI
acts upstream of or within nervous system process	IMP IMP: Inferred from mutant phenotype	24277578	MGI
acts upstream of or within neuron apoptotic process	IDA IDA: Inferred from direct assay	21459131	MGI
acts upstream of or within organelle organization	IMP IMP: Inferred from mutant phenotype	21037586	MGI
acts upstream of or within ossification	IMP IMP: Inferred from mutant phenotype	19248115	MGI
acts upstream of or within peripheral nervous system development	IMP IMP: Inferred from mutant phenotype	24277578	MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	21459131	MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	26565691	MGI
acts upstream of or within protein lipidation	IMP IMP: Inferred from mutant phenotype	26565691	MGI
acts upstream of or within protein phosphorylation	IMP IMP: Inferred from mutant phenotype	19114551	MGI
acts upstream of or within protein tetramerization	IDA IDA: Inferred from direct assay	23300779	MGI
acts upstream of or within reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	20716577	MGI
acts upstream of or within reduction of food intake in response to dietary excess	IMP IMP: Inferred from mutant phenotype	19114551	MGI
acts upstream of or within regulation of cell size	IMP IMP: Inferred from mutant phenotype	19114551	MGI
acts upstream of or within regulation of collagen fibril organization	IMP IMP: Inferred from mutant phenotype	20951202	MGI
acts upstream of or within respiratory system process	IMP IMP: Inferred from mutant phenotype	19114551	MGI
acts upstream of or within response to UV	IDA IDA: Inferred from direct assay	21459131	MGI
acts upstream of or within response to activity	IMP IMP: Inferred from mutant phenotype	24357721	MGI
acts upstream of or within response to bleomycin	IMP IMP: Inferred from mutant phenotype	25158062	MGI
acts upstream of or within response to decreased oxygen levels	IMP IMP: Inferred from mutant phenotype	22343710	MGI
acts upstream of or within response to lipid	IMP IMP: Inferred from mutant phenotype	23437220	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	19114551	MGI
acts upstream of or within response to mechanical stimulus	IMP IMP: Inferred from mutant phenotype	19248115	MGI
acts upstream of or within response to muscle activity	IMP IMP: Inferred from mutant phenotype	22024752	MGI
acts upstream of or within response to pain	IMP IMP: Inferred from mutant phenotype	24277578	MGI
acts upstream of or within response to peptide	IMP IMP: Inferred from mutant phenotype	24852368	MGI
acts upstream of or within response to polyamine macromolecule	IMP IMP: Inferred from mutant phenotype	26565691	MGI
acts upstream of or within response to reactive oxygen species	IMP IMP: Inferred from mutant phenotype	20716577	MGI
acts upstream of or within response to toxic substance	IMP IMP: Inferred from mutant phenotype	23437220	MGI
acts upstream of or within response to wounding	IDA IDA: Inferred from direct assay	25989472	MGI
acts upstream of or within response to wounding	IMP IMP: Inferred from mutant phenotype	22343710	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	19519726	MGI
acts upstream of or within sensory perception of mechanical stimulus	IMP IMP: Inferred from mutant phenotype	23437220	MGI
acts upstream of or within single fertilization	IGI IGI: Inferred from genetic interaction	28604699	MGI
acts upstream of or within skeletal muscle fiber development	IMP IMP: Inferred from mutant phenotype	21037586	MGI
acts upstream of or within skeletal muscle fiber differentiation	IGI IGI: Inferred from genetic interaction	19293339	MGI
acts upstream of or within skeletal muscle organ development	IMP IMP: Inferred from mutant phenotype	26565691	MGI
acts upstream of or within skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	19248115	MGI
acts upstream of or within skeletal muscle tissue growth	IMP IMP: Inferred from mutant phenotype	28043812	MGI
acts upstream of or within skeletal muscle tissue regeneration	IMP IMP: Inferred from mutant phenotype	28043812	MGI
acts upstream of or within skin development	IMP IMP: Inferred from mutant phenotype	25158062	MGI
acts upstream of or within tissue remodeling	IMP IMP: Inferred from mutant phenotype	22343710	MGI
acts upstream of or within transmission of nerve impulse	IMP IMP: Inferred from mutant phenotype	24277578	MGI
acts upstream of or within tricarboxylic acid cycle	IMP IMP: Inferred from mutant phenotype	23437220	MGI
acts upstream of or within uterus development	IGI IGI: Inferred from genetic interaction	28604699	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in basement membrane	IDA IDA: Inferred from direct assay	31837950	MGI
is active in extracellular matrix	IDA IDA: Inferred from direct assay	19248115	MGI
located in extracellular matrix	IDA IDA: Inferred from direct assay	8806434	MGI
is active in extracellular matrix	IMP IMP: Inferred from mutant phenotype	20951202	MGI
is active in intracellular vesicle	IDA IDA: Inferred from direct assay	24357721	MGI
is active in lysosome	IDA IDA: Inferred from direct assay	28604699	MGI
is active in myofibril	IMP IMP: Inferred from mutant phenotype	20716577	MGI
located in sarcolemma	IDA IDA: Inferred from direct assay	16810681	MGI
is active in sarcoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	22024752	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

collagen alpha-1(VI) chain

procollagen, type VI, alpha 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02992	COL6A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19250	Col6a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25739	Col6a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Col6a1	NCBI	NCBI:1291

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