Cfc1 - cripto, FRL-1, cryptic family 1 Gene

Mus musculus

Also known as cryptic; b2b970Clo

Gene ID: 12627 | Gene type: protein coding

About Cfc1

Summary

Enables activin receptor binding activity. Involved in nodal signaling pathway. Acts upstream of or within several processes, including animal organ development; digestive tract morphogenesis; and endoderm development. Predicted to be located in plasma membrane. Predicted to be active in cell surface and extracellular region. Is expressed in several structures, including embryo mesoderm; intermediate mesenchyme; neural ectoderm; and primitive streak. Used to study dextro-looped transposition of the great arteries; double outlet right ventricle; right atrial isomerism; and visceral heterotaxy. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human CFC1 (cripto, FRL-1, cryptic family 1) and CFC1B (cripto, FRL-1, cryptic family 1B). [provided by Alliance of Genome Resources, Apr 2022]

Cfc1 Products(1)

mRNA	Protein	Name
NM_007685.2	NP_031711.1	cryptic protein precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables activin receptor binding	IPI IPI: Inferred from physical interaction	12052855	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within anatomical structure development	IGI IGI: Inferred from genetic interaction	11412024	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	11412024	MGI
acts upstream of or within atrial septum morphogenesis	IMP IMP: Inferred from mutant phenotype	10521397	MGI
acts upstream of or within coronary vasculature development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	10521397	MGI
acts upstream of or within digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	10521397	MGI
acts upstream of or within endoderm development	IGI IGI: Inferred from genetic interaction	11412024	MGI
acts upstream of or within heart looping	IMP IMP: Inferred from mutant phenotype	10521397	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	10521397	MGI
acts upstream of or within left lung morphogenesis	IMP IMP: Inferred from mutant phenotype	10521397	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	10521397	MGI
involved in nodal signaling pathway	IMP IMP: Inferred from mutant phenotype	12052855	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	10521397	MGI
acts upstream of or within respiratory system development	IMP IMP: Inferred from mutant phenotype	10521397	MGI
acts upstream of or within spleen development	IMP IMP: Inferred from mutant phenotype	10521397	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cryptic protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02558	CFC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21309	Cfc1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cfc1	NCBI	NCBI:55997

Name
Email *

	Sorry, but the email address you supplied was invalid.