Cbfb - core binding factor beta Gene

Mus musculus

Also known as PEA2; Pebp2; PEBP2b; Pebpb2

Gene ID: 12400 | Gene type: protein coding

About Cbfb

Summary

Contributes to sequence-specific DNA binding activity. Involved in negative regulation of CD4-positive, alpha-beta T cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of CD8-positive, alpha-beta T cell differentiation. Acts upstream of or within several processes, including hemopoiesis; osteoblast differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human CBFB (core-binding factor subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Cbfb Products(4)

mRNA	Protein	Name
NM_001161456.1	NP_001154928.1	core-binding factor subunit beta isoform 2
NM_001161457.1	NP_001154929.1	core-binding factor subunit beta isoform 3
NM_001161458.1	NP_001154930.1	core-binding factor subunit beta isoform 4
NM_022309.4	NP_071704.3	core-binding factor subunit beta isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11404095	MGI
contributes to sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18258917	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell maturation	IMP IMP: Inferred from mutant phenotype	12434156	MGI
acts upstream of or within definitive hemopoiesis	IMP IMP: Inferred from mutant phenotype	9159135	MGI
acts upstream of or within lymphocyte differentiation	IMP IMP: Inferred from mutant phenotype	12434155	MGI
acts upstream of or within myeloid cell differentiation	IMP IMP: Inferred from mutant phenotype	12434155	MGI
involved in negative regulation of CD4-positive, alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	18258917	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18258917	MGI
acts upstream of or within ossification	IMP IMP: Inferred from mutant phenotype	12434155	MGI
acts upstream of or within osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	12434156	MGI
involved in positive regulation of CD8-positive, alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	18258917	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12434156	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12434156	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

core-binding factor subunit beta

CBF-beta	PEA2-beta
PEBP2-beta	SL3-3 enhancer factor 1 subunit beta
SL3/AKV core-binding factor beta subunit	polyomavirus enhancer-binding protein 2 beta subunit

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108470	Ro5-3335	Inhibitor	99.52%	Unkown
HY-RS01995	CBFB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-124137	Runx1-CBFβ interaction inhibitor 1	Inhibitor	/	Unkown
HY-RS18748	Cbfb Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25235	Cbfb Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cbfb	NCBI	NCBI:865

Name
Email *

	Sorry, but the email address you supplied was invalid.