Gdf2 - growth differentiation factor 2 Gene

Mus musculus

Also known as Bmp9

Gene ID: 12165 | Gene type: protein coding

About Gdf2

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Homozygous null mice exhibit malformations of the vasculature and skeleton. [provided by RefSeq, Jul 2016]

Gdf2 Products(1)

mRNA	Protein	Name
NM_019506.4	NP_062379.3	growth/differentiation factor 2 preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20406889	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in branching involved in blood vessel morphogenesis	IDA IDA: Inferred from direct assay	20406889	MGI
acts upstream of or within osteoblast differentiation	IGI IGI: Inferred from genetic interaction	15161906	MGI
involved in positive regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	20406889	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20406889	MGI
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	20406889	MGI
involved in positive regulation of cartilage development	IDA IDA: Inferred from direct assay	19956691	MGI
involved in positive regulation of endothelial cell differentiation	IDA IDA: Inferred from direct assay	20406889	MGI
involved in positive regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	20406889	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	22783020	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18997172	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	18986983	MGI
NOT involved in regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	20406889	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18997172	MGI
involved in vasculogenesis	IDA IDA: Inferred from direct assay	20406889	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

growth/differentiation factor 2

bone morphogenetic protein 9

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05353	GDF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19136	Gdf2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25626	Gdf2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gdf2	NCBI	NCBI:2658

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