Arf6 - ADP-ribosylation factor 6 Gene

Mus musculus

Gene ID: 11845 | Gene type: protein coding

About Arf6

Summary

Enables protein N-terminus binding activity. Involved in several processes, including negative regulation of protein localization to cell surface; positive regulation of focal adhesion disassembly; and positive regulation of keratinocyte migration. Acts upstream of or within several processes, including hepatocyte apoptotic process; liver development; and myeloid cell apoptotic process. Located in endosome and plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system; and respiratory system. Orthologous to human ARF6 (ADP ribosylation factor 6). [provided by Alliance of Genome Resources, Apr 2022]

Arf6 Products(1)

mRNA	Protein	Name
NM_007481.3	NP_031507.1	ADP-ribosylation factor 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20493856	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within erythrocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	16880525	MGI
acts upstream of or within establishment of epithelial cell polarity	IMP IMP: Inferred from mutant phenotype	20080746	MGI
acts upstream of or within hepatocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	16880525	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	16880525	MGI
involved in negative regulation of protein localization to cell surface	IDA IDA: Inferred from direct assay	29420262	MGI
involved in positive regulation of focal adhesion disassembly	IMP IMP: Inferred from mutant phenotype	25490267	MGI
involved in positive regulation of keratinocyte migration	IMP IMP: Inferred from mutant phenotype	25490267	MGI
involved in positive regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	16751103	MGI
involved in protein localization to cell surface	IDA IDA: Inferred from direct assay	16751103	MGI
involved in protein localization to endosome	IMP IMP: Inferred from mutant phenotype	23572513	MGI
involved in regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	16325184	MGI
acts upstream of or within regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	27330119	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8947846	MGI
located in endosome	IDA IDA: Inferred from direct assay	16751103	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	8947846	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ADP-ribosylation factor 6

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112473	NAV-2729	Inhibitor	99.10%	Unkown
HY-139950	Rasarfin	Inhibitor	99.57%	Unkown
HY-P10178	Myristoylated ARF6 (2-13)	Inhibitor	/	Unkown
HY-P10179	ARF6 (2-13)		/	Unkown
HY-RS00898	ARF6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18229	Arf6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24708	Arf6 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arf6	NCBI	NCBI:382

Name
Email *

	Sorry, but the email address you supplied was invalid.