2. Gene
  3. Ank3 - ankyrin 3, epithelial Gene

Ank3 - ankyrin 3, epithelial Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as AnkG; Ank-3; Ankyrin-3; Ankyrin-G; 2900054D09Rik

Gene ID: 11735 | Gene type: protein coding

About Ank3

Summary

This gene encodes a member of the ankyrin protein family. Ankyrins link integral membrane proteins to the spectrin-based Cytoskeleton. Ankyrin family members share a protein structure which includes three independently folded domains: the N-terminal ankyrin repeat domain, the central spectrin-binding domain, and the C-terminal rod domain. This ankyrin functions as the major ankyrin in the kidney and may play a role in the polarized distribution of many integral membrane proteins to specific subcellular sites. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Ank3 Products(9)

mRNA Protein Name
NM_009670.4 NP_033800.2 ankyrin-3 isoform g
NM_146005.3 NP_666117.2 ankyrin-3 isoform b
NM_170687.3 NP_733788.2 ankyrin-3 isoform f
NM_170688.2 NP_733789.1 ankyrin-3 isoform c
NM_170689.2 NP_733790.2 ankyrin-3 isoform d
NM_170690.2 NP_733791.2 ankyrin-3 isoform e
NM_170728.2 NP_733924.2 ankyrin-3 isoform a
NM_170729.2 NP_733925.2 ankyrin-3 isoform h
NM_170730.2 NP_733926.2 ankyrin-3 isoform i
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
14762142 MGI
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
23903368 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
15479642 MGI
involved in axonogenesis IMP
IMP: Inferred from mutant phenotype
11724816 MGI
involved in cellular response to magnesium ion IMP
IMP: Inferred from mutant phenotype
23903368 MGI
involved in magnesium ion homeostasis IMP
IMP: Inferred from mutant phenotype
23903368 MGI
involved in negative regulation of delayed rectifier potassium channel activity IMP
IMP: Inferred from mutant phenotype
23903368 MGI
involved in neuronal action potential IMP
IMP: Inferred from mutant phenotype
9832557 MGI
acts upstream of or within protein localization to axon IMP
IMP: Inferred from mutant phenotype
26671463 MGI
involved in protein localization to plasma membrane IDA
IDA: Inferred from direct assay
11724816 MGI
involved in protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
16525039 MGI
acts upstream of or within synapse organization IMP
IMP: Inferred from mutant phenotype
15479642 MGI
Cellular Component GO Annotation Evidence Reference Source
located in axon IDA
IDA: Inferred from direct assay
15479642 MGI
located in axon initial segment IDA
IDA: Inferred from direct assay
11724816 MGI
located in axon initial segment IMP
IMP: Inferred from mutant phenotype
25950943 MGI
located in intercalated disc IDA
IDA: Inferred from direct assay
20877009 MGI
located in membrane IDA
IDA: Inferred from direct assay
7615634 MGI
located in node of Ranvier IDA
IDA: Inferred from direct assay
11724816 MGI
located in paranode region of axon IDA
IDA: Inferred from direct assay
20188654 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
31813652 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
33398084 MGI
located in synapse IDA
IDA: Inferred from direct assay
10995443 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ankyrin-3

brain-specific ankyrin-G

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00701 ANK3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19574 Ank3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26071 Ank3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ank3 NCBI NCBI:288