Lct - lactase Gene

Rattus norvegicus

Also known as Lph

Gene ID: 116569 | Gene type: protein coding

About Lct

Summary

Enables lactase activity and transferase activity. Involved in several processes, including response to estrogen; response to iron(II) ion; and response to lead ion. Located in brush border. Used to study diarrhea. Biomarker of colitis. Human ortholog(s) of this gene implicated in congenital lactase deficiency. Orthologous to human LCT (lactase). [provided by Alliance of Genome Resources, Apr 2022]

Lct Products(1)

mRNA	Protein	Name
NM_053841.1	NP_446293.1	lactase/phlorizin hydrolase preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-glucosidase activity	IDA IDA: Inferred from direct assay	4752949	RGD
enables galactosylceramidase activity	IDA IDA: Inferred from direct assay	4752949	RGD
enables glucosylceramidase activity	IDA IDA: Inferred from direct assay	4752949	RGD
enables lactase activity	IDA IDA: Inferred from direct assay	4752949	RGD
enables phlorizin hydrolase activity	IDA IDA: Inferred from direct assay	4752949	RGD
enables transferase activity	IDA IDA: Inferred from direct assay	12023280	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellobiose catabolic process	IDA IDA: Inferred from direct assay	4752949	RGD
involved in glycosylceramide catabolic process	IDA IDA: Inferred from direct assay	4752949	RGD
involved in lactose catabolic process	IDA IDA: Inferred from direct assay	4752949	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	16396664	RGD
involved in response to ethanol	IDA IDA: Inferred from direct assay	15849819	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	17190105	RGD
involved in response to hypoxia	IDA IDA: Inferred from direct assay	12773704	RGD
involved in response to iron(II) ion	IDA IDA: Inferred from direct assay	16081762	RGD
involved in response to lead ion	IDA IDA: Inferred from direct assay	16092086	RGD
involved in response to nickel cation	IDA IDA: Inferred from direct assay	16819762	RGD
involved in response to nutrient	IDA IDA: Inferred from direct assay	16497337	RGD
involved in response to starvation	IEP IEP: Inferred from expression pattern	17190105	RGD
involved in response to sucrose	IEP IEP: Inferred from expression pattern	17190105	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	17147060	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in brush border	IDA IDA: Inferred from direct assay	12023280	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

lactase/phlorizin hydrolase

lactase-glycosylceramidase

lactase-phlorizin hydrolase

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07565	LCT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19864	Lct Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26363	Lct Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lct	NCBI	NCBI:3938

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