2. Gene
  3. Ggt1 - gamma-glutamyltransferase 1 Gene

Ggt1 - gamma-glutamyltransferase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Ggt; Ggtp; GGLUT

Gene ID: 116568 | Gene type: protein coding

About Ggt1

Summary

Enables aminoacyltransferase activity. Involved in several processes, including liver development; peptide modification; and response to estradiol. Located in extracellular space. Biomarker of alcohol dependence. Human ortholog(s) of this gene implicated in gamma-glutamyl transpeptidase deficiency. Orthologous to several human genes including GGT1 (gamma-glutamyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ggt1 Products(1)

mRNA Protein Name
NM_053840.2 NP_446292.2 glutathione hydrolase 1 proenzyme
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables aminoacyltransferase activity IDA
IDA: Inferred from direct assay
2567161 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to oxidative stress IEP
IEP: Inferred from expression pattern
18075840 RGD
involved in hepatoblast differentiation IEP
IEP: Inferred from expression pattern
10934156 RGD
involved in hepatocyte differentiation IEP
IEP: Inferred from expression pattern
10934156 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
10934156 RGD
involved in peptide modification IDA
IDA: Inferred from direct assay
11601992 RGD
involved in response to alcohol IEP
IEP: Inferred from expression pattern
6113606 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
18291430 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
19699728 RGD
involved in response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
16973162 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
18291430 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutathione hydrolase 1 proenzyme

GGT 1

gamma glutamyl-transferase 1

gamma-glutamyl transpeptidase

gamma-glutamyltranspeptidase 1

leukotriene-C4 hydrolase

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-128350 FGTI-2734 Inhibitor 99.85% Unkown
HY-RS05403 GGT1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-118916A FTI-2148 diTFA Inhibitor / Unkown
HY-118916 FTI-2148 Inhibitor / Unkown
HY-RS18244 Ggt1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24723 Ggt1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ggt1 NCBI NCBI:2678