Kcnk4 - potassium two pore domain channel subfamily K member 4 Gene

Rattus norvegicus

Also known as KT4.1; TRAAK

Gene ID: 116489 | Gene type: protein coding

About Kcnk4

Summary

Enables mechanosensitived Potassium Channel activity and temperature-gated cation channel activity. Involved in several processes, including cellular response to alkaline pH; cellular response to temperature stimulus; and potassium ion transmembrane transport. Is integral component of plasma membrane. Orthologous to human KCNK4 (potassium two pore domain channel subfamily K member 4). [provided by Alliance of Genome Resources, Apr 2022]

Kcnk4 Products(1)

mRNA	Protein	Name
NM_053804.3	NP_446256.3	potassium channel subfamily K member 4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mechanosensitive potassium channel activity	IDA IDA: Inferred from direct assay	15677687	RGD
enables potassium channel activity	IDA IDA: Inferred from direct assay	11374070	RGD
enables potassium ion leak channel activity	IDA IDA: Inferred from direct assay	31630908	RGD
enables temperature-gated cation channel activity	IDA IDA: Inferred from direct assay	15677687	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to alkaline pH	IDA IDA: Inferred from direct assay	15677687	RGD
involved in cellular response to fatty acid	IDA IDA: Inferred from direct assay	15677687	RGD
involved in cellular response to temperature stimulus	IDA IDA: Inferred from direct assay	15677687	RGD
involved in detection of mechanical stimulus involved in sensory perception of touch	IMP IMP: Inferred from mutant phenotype	31630908	RGD
involved in memory	IEP IEP: Inferred from expression pattern	14730890	RGD
involved in neuronal action potential	IMP IMP: Inferred from mutant phenotype	31630908	RGD
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	15677687	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in node of Ranvier	IDA IDA: Inferred from direct assay	31630908	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	15677687	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

potassium channel subfamily K member 4

TWIK-related arachidonic acid-stimulated potassium channel protein	potassium channel, two pore domain subfamily K, member 4
potassium inwardly-rectifying channel, subfamily K, member 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1500	2,2,2-Trichloroethanol	Agonist	99.53%	Unkown
HY-RS07160	KCNK4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21613	Kcnk4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS28131	Kcnk4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnk4	NCBI	NCBI:50801

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