2. Gene
  3. Acan - aggrecan Gene

Acan - aggrecan Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Agc; cmd; Agc1; CSPCP; Cspg1; b2b183Clo

Gene ID: 11595 | Gene type: protein coding

About Acan

Summary

Predicted to enable calcium ion binding activity. Acts upstream of or within several processes, including cartilage development; Collagen fibril organization; and proteoglycan biosynthetic process. Located in GABA-ergic synapse; basement membrane; and glutamatergic synapse. Is active in perisynaptic extracellular matrix. Is expressed in several structures, including genitourinary system; limb; main olfactory bulb; sensory organ; and skeletal system. Used to study achondroplasia. Human ortholog(s) of this gene implicated in spondyloepiphyseal dysplasia Kimberley type. Orthologous to human ACAN (aggrecan). [provided by Alliance of Genome Resources, Apr 2022]

Acan Products(2)

mRNA Protein Name
NM_001361500.1 NP_001348429.1 aggrecan core protein isoform 1 precursor
NM_007424.3 NP_031450.2 aggrecan core protein isoform 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
9368062 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cartilage condensation IMP
IMP: Inferred from mutant phenotype
3070812 MGI
acts upstream of or within chondrocyte development IMP
IMP: Inferred from mutant phenotype
9664687 MGI
acts upstream of or within collagen fibril organization IMP
IMP: Inferred from mutant phenotype
3070812 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within proteoglycan biosynthetic process IMP
IMP: Inferred from mutant phenotype
3070812 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
27615741 MGI
located in basement membrane IDA
IDA: Inferred from direct assay
16061471 MGI
located in extracellular matrix IDA
IDA: Inferred from direct assay
14620382 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
27615741 MGI
is active in perisynaptic extracellular matrix IDA
IDA: Inferred from direct assay
27615741 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aggrecan core protein

aggrecan 1

cartilage-specific proteoglycan core protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00132 ACAN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17876 Acan Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24345 Acan Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acan NCBI NCBI:176