Kcnq3 - potassium voltage-gated channel, subfamily Q, member 3 Gene

Mus musculus

Gene ID: 110862 | Gene type: protein coding

About Kcnq3

Summary

Enables Calmodulin binding activity; Potassium Channel activity; and voltage-gated ion channel activity. Acts upstream of or within membrane hyperpolarization and potassium ion transmembrane transport. Located in cell surface; main axon; and plasma membrane. Part of voltage-gated Potassium Channel complex. Is expressed in several structures, including central nervous system; midgut; retina; and rib. Used to study benign neonatal seizures. Human ortholog(s) of this gene implicated in autistic disorder and benign neonatal seizures. Orthologous to human KCNQ3 (potassium voltage-gated channel subfamily Q member 3). [provided by Alliance of Genome Resources, Apr 2022]

Kcnq3 Products(1)

mRNA	Protein	Name
NM_152923.3	NP_690887.2	potassium voltage-gated channel subfamily KQT member 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calmodulin binding	IMP IMP: Inferred from mutant phenotype	24333508	MGI
enables calmodulin binding	IPI IPI: Inferred from physical interaction	12223552	MGI
enables potassium channel activity	IGI IGI: Inferred from genetic interaction	23716673	MGI
enables potassium channel activity	IMP IMP: Inferred from mutant phenotype	19060215	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	24333508	MGI
enables voltage-gated monoatomic ion channel activity	IGI IGI: Inferred from genetic interaction	12223552	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within action potential initiation	IDA IDA: Inferred from direct assay	26312501	MGI
acts upstream of or within action potential initiation	IGI IGI: Inferred from genetic interaction	23716673	MGI
acts upstream of or within action potential initiation	IMP IMP: Inferred from mutant phenotype	26733196	MGI
acts upstream of or within apoptosome assembly	IMP IMP: Inferred from mutant phenotype	20885443	MGI
acts upstream of or within cellular response to calcium ion	IDA IDA: Inferred from direct assay	23259949	MGI
acts upstream of or within cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	23259949	MGI
acts upstream of or within endocytosis	IMP IMP: Inferred from mutant phenotype	21466805	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	19060215	MGI
acts upstream of or within excitatory chemical synaptic transmission	IGI IGI: Inferred from genetic interaction	30382937	MGI
acts upstream of or within exocytosis	IMP IMP: Inferred from mutant phenotype	21466805	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	18483067	MGI
acts upstream of or within inhibitory chemical synaptic transmission	IGI IGI: Inferred from genetic interaction	30382937	MGI
acts upstream of or within membrane hyperpolarization	IMP IMP: Inferred from mutant phenotype	19060215	MGI
acts upstream of or within mitochondrial depolarization	IMP IMP: Inferred from mutant phenotype	20885443	MGI
acts upstream of or within monoatomic ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	18483067	MGI
acts upstream of or within nerve development	IMP IMP: Inferred from mutant phenotype	18483067	MGI
acts upstream of or within neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	20885443	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	21466805	MGI
acts upstream of or within neuron remodeling	IGI IGI: Inferred from genetic interaction	30382937	MGI
acts upstream of or within neuronal action potential	IMP IMP: Inferred from mutant phenotype	24719109	MGI
acts upstream of or within potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	19060215	MGI
acts upstream of or within protein import into nucleus	IMP IMP: Inferred from mutant phenotype	20885443	MGI
acts upstream of or within protein phosphorylation	IMP IMP: Inferred from mutant phenotype	21466805	MGI
acts upstream of or within protein targeting	IMP IMP: Inferred from mutant phenotype	24333508	MGI
acts upstream of or within protein transport	IMP IMP: Inferred from mutant phenotype	20885443	MGI
acts upstream of or within protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	24333508	MGI
acts upstream of or within psychomotor behavior	IMP IMP: Inferred from mutant phenotype	19453707	MGI
acts upstream of or within regulation of action potential firing threshold	IGI IGI: Inferred from genetic interaction	23716673	MGI
acts upstream of or within regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	18483067	MGI
acts upstream of or within response to auditory stimulus	IDA IDA: Inferred from direct assay	26312501	MGI
acts upstream of or within response to auditory stimulus	IGI IGI: Inferred from genetic interaction	23716673	MGI
acts upstream of or within response to mechanical stimulus	IMP IMP: Inferred from mutant phenotype	26733196	MGI
acts upstream of or within response to organic cyclic compound	IDA IDA: Inferred from direct assay	20885443	MGI
acts upstream of or within sensory perception of sound	IGI IGI: Inferred from genetic interaction	23716673	MGI
acts upstream of or within substantia propria of cornea development	IMP IMP: Inferred from mutant phenotype	19453707	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in axon initial segment	IDA IDA: Inferred from direct assay	14762142	MGI
located in axon initial segment	IDA IDA: Inferred from direct assay	16525039	MGI
is active in axon initial segment	IMP IMP: Inferred from mutant phenotype	24333508	MGI
is active in cell surface	IDA IDA: Inferred from direct assay	14762142	MGI
located in cell surface	IDA IDA: Inferred from direct assay	12223552	MGI
is active in node of Ranvier	IDA IDA: Inferred from direct assay	14762142	MGI
located in node of Ranvier	IDA IDA: Inferred from direct assay	16525039	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16525039	MGI
part of voltage-gated potassium channel complex	IGI IGI: Inferred from genetic interaction	12223552	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily KQT member 3

KQT-like 3	potassium channel subunit alpha KvLQT3
voltage-gated potassium channel subunit Kv7.3

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108577	XE991 dihydrochloride	Inhibitor	99.63%	Unkown
HY-122114	ICA-27243	Activator	99.27%	Unkown
HY-108577A	XE991	Inhibitor	/	Unkown
HY-RS07175	KCNQ3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19700	Kcnq3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26195	Kcnq3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnq3	NCBI	NCBI:3786

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