Fosb - FosB proto-oncogene, AP-1 transcription factor subunit Gene

Rattus norvegicus

Also known as fra-2

Gene ID: 100360880 | Gene type: protein coding

About Fosb

Summary

Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including response to cAMP; response to morphine; and response to steroid hormone. Located in nucleus. Orthologous to human FOSB (FosB proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]

Fosb Products(1)

mRNA	Protein	Name
NM_001256509.1	NP_001243438.1	protein FosB

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	10830307	RGD
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	10830307	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10830307	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in behavioral response to cocaine	IEP IEP: Inferred from expression pattern	20633205	RGD
involved in cellular response to hormone stimulus	IEP IEP: Inferred from expression pattern	11460264	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	12080023	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	31373119	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	10934195	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	17572394	RGD
involved in response to corticosterone	IEP IEP: Inferred from expression pattern	18485334	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	19324071	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	15126239	RGD
involved in response to morphine	IEP IEP: Inferred from expression pattern	20438612	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	11750070	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	12093589	RGD
involved in transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10830307	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	20438612	RGD
located in nucleus	IDA IDA: Inferred from direct assay	17572394	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein FosB

protein fosB

FBJ osteosarcoma oncogene B

transcription factor AP-1 subunit FosB

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N12361	Osmanthuside B	Inhibitor	98.40%	Unkown
HY-170916	Angiogenesis inhibitor 7	Inhibitor	/	Unkown
HY-RS05033	FOSB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17952	Fosb Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24423	Fosb Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fosb	NCBI	NCBI:2354

Name
Email *

	Sorry, but the email address you supplied was invalid.