2. Anti-infection
  3. Bacterial Urease
  4. Flurofamide

Flurofamide is an effective bacterial urease inhibitor and antibacterial agent. Flurofamide inhibits urease and partially inhibits the chemotactic activity of Helicobacter pylori strain CPY3401. Flurofamide inhibits the growth of Ureaplasma urealyticum. Flurofamide reduces blood ammonia. Flurofamide can be used in the research of infectious urinary stones.

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Flurofamide

Flurofamide Chemical Structure

CAS No. : 70788-28-2

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

Flurofamide Related Antibodies

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  • Purity & Documentation

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Description

Flurofamide is an effective bacterial urease inhibitor and antibacterial agent. Flurofamide inhibits urease and partially inhibits the chemotactic activity of Helicobacter pylori strain CPY3401. Flurofamide inhibits the growth of Ureaplasma urealyticum. Flurofamide reduces blood ammonia. Flurofamide can be used in the research of infectious urinary stones[1][2][3][4].

In Vitro

Flufatamide inhibits NH3 production in 4 isolates of Ureaplasma parvum and 5 isolates of Ureaplasma urealyticum, with the minimum urease inhibition concentration ≤ 2 μM, confirming that it is a broad-spectrum Ureaplasma urease inhibitor[1].
Flurofamide (0.01-10 μM) partially inhibits the chemotactic activity of Helicobacter pylori CPY3401 strain in chemotactic buffer containing 3% Polyvinylpyrrolidone (simulating a viscous environment)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Flurofamide Related Antibodies
In Vivo

Flurofamide (6 mg/kg; i.p., 1 h before infection in the prophylaxis group and 24 h after infection in the treatment group) significantly reduces blood ammonia levels in the prophylaxis group 24 hours later, and makes the reduction of blood ammonia levels in the treatment group 6 h later significantly greater than that in the untreated group in the Ureaplasma respiratory infection model of immunosuppressed C3H mice with induced mild uremia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C3H male and female mice (18-22 g), pharmacologically immunosuppressed with methylprednisone, tacrolimus, and mycophenolate mofetil for 7 days, and administered 40 g/L urea ad libitum in drinking water for 10 min to induce mild uremia, then infected with Ureaplasma parvum IDRL-10774 via intratracheal (IT) and intraperitoneal (IP) routes[1]
Dosage: 6 mg/kg
Administration: Intraperitoneal (IP) injection; for prophylaxis group, administered 1 hour prior to IT and IP Ureaplasma challenge; for treatment group, administered 24 hours after IT and IP infection
Result: Showed the average blood NH3 level of 10.9 μM (in the prophylaxis group, 24 hours after infection).
Caused a 56.4% decrease in blood NH3 concentration in infected mice with initial blood NH3 concentration >30 μM, which was significantly higher than the 9.1% decrease in blood NH3 concentration in untreated infected mice (in the treatment group, 6 h after administration).
Molecular Weight

217.14

Formula

C7H9FN3O2P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NP(N)(N)=O)C1=CC=C(F)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 14.29 mg/mL (65.81 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6053 mL 23.0266 mL 46.0532 mL
5 mM 0.9211 mL 4.6053 mL 9.2106 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 1.43 mg/mL (6.59 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.43 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (14.3 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 92.6%

SDS (252 KB)

COA (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.6053 mL 23.0266 mL 46.0532 mL 115.1331 mL
5 mM 0.9211 mL 4.6053 mL 9.2106 mL 23.0266 mL
10 mM 0.4605 mL 2.3027 mL 4.6053 mL 11.5133 mL
15 mM 0.3070 mL 1.5351 mL 3.0702 mL 7.6755 mL
20 mM 0.2303 mL 1.1513 mL 2.3027 mL 5.7567 mL
25 mM 0.1842 mL 0.9211 mL 1.8421 mL 4.6053 mL
30 mM 0.1535 mL 0.7676 mL 1.5351 mL 3.8378 mL
40 mM 0.1151 mL 0.5757 mL 1.1513 mL 2.8783 mL
50 mM 0.0921 mL 0.4605 mL 0.9211 mL 2.3027 mL
60 mM 0.0768 mL 0.3838 mL 0.7676 mL 1.9189 mL
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Flurofamide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flurofamide70788-28-2BacterialUreaseInhibitorinhibitorinhibit

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