Deglycobleomycin 

Deglycobleomycin is an RNA cleavage agent targeting r(CUG) repeat sequences. Deglycobleomycin can selectively cleave r(CUG)^exp after binding to a small molecule that recognizes r(CUG)^exp. The DNA cleavage efficiency of deglycobleomycin is much lower than that of Bleomycin A5 (Pingyangmycin) (HY-N10470). However, deglycobleomycin has enhanced selective cleavage activity against r(CUG)^exp. Deglycobleomycin can be used to study diseases related to r(CUG)^exp expansion (such as myotonic dystrophy type 1); and for the development of drugs that precisely target and cleave pathogenic RNA^[1].

1058.20

C₄₂H₆₃N₁₉O₁₀S₂

78314-57-5

NC([C@@H](N)CN[C@H](C1=NC(N)=C(C)C(C(N[C@H](C(N[C@H](C)[C@@H](O)[C@H](C)C(N[C@@H]([C@H](O)C)C(NCCC2=NC(C3=NC(C(NCCCCNC(N)=N)=O)=CS3)=CS2)=O)=O)=O)[C@H](C4=CN=CN4)O)=O)=N1)CC(N)=O)=O

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• [1]. Angelbello AJ, et al. Precise Targeted Cleavage of a r(CUG) Repeat Expansion in Cells by Using a Small-Molecule-Deglycobleomycin Conjugate. ACS Chem Biol. 2020 Apr 17;15(4):849-855.