DBCO-PEG2-Val-Cit-PAB-MMAE

Cat. No.: HY-172287 Purity: 99.27%: Data Sheet
COA

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DBCO-PEG2-Val-Cit-PAB-MMAE is an ADC linker featuring a DBCO group, a Val-Cit dipeptide, a PAB motif, and an MMAE warhead. The DBCO group is a click chemistry handle which readily reacts with azide groups, while the Val-Cit is a protease-cleavable dipeptide which releases the MMAE warhead into cells via an elimination mechanism.

For research use only. We do not sell to patients.

DBCO-PEG2-Val-Cit-PAB-MMAE Chemical Structure

CAS No. : 2845934-59-8

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description	DBCO-PEG2-Val-Cit-PAB-MMAE is an ADC linker featuring a DBCO group, a Val-Cit dipeptide, a PAB motif, and an MMAE warhead. The DBCO group is a click chemistry handle which readily reacts with azide groups, while the Val-Cit is a protease-cleavable dipeptide which releases the MMAE warhead into cells via an elimination mechanism.
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. DBCO-PEG2-Val-Cit-PAB-MMAE Related Antibodies
Molecular Weight	1569.92
Formula	C₈₄H₁₂₀N₁₂O₁₇
CAS No.	2845934-59-8
Appearance	Solid
Color	White to off-white
SMILES	O=C(N1[C@](CCC1)([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C2=CC=CC=C2)O)=O)C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC(C=C3)=CC=C3NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCNC(CCC(N4C5=CC=CC=C5C#CC6=CC=CC=C6C4)=O)=O)=O)=O)=O)=O)=O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Purity & Documentation	Purity: 99.27% Select Batch: Data Sheet (240 KB) SDS (252 KB) COA (246 KB) HNMR (340 KB) RP-HPLC (230 KB) MS (71 KB) Handling Instructions (2659 KB)