2. Signaling Pathways
  3. Neuronal Signaling
  4. Tau Protein
  5. Tau Protein Ligand

Tau Protein Ligand

Tau Protein Ligands (4):

Cat. No. Product Name Effect Purity
  • HY-138679
    Aberrant tau ligand 2
    		Ligand
    Aberrant tau ligand 2 (Compound 4-12) is the ligand for tau protein and can be used as target protein ligand for synthesis of PROTAC degrader C004019 (HY-138669).
  • HY-101186
    MK-6240
    		Ligand 99.60%
    MK-6240 is a blood-brain barrier-permeable positron emission tomography (PET) tracer targeting neurofibrillary tangles (NFTs) (Kd = 0.42 nM). MK-6240 can be used for imaging neurofibrillary tangle pathology in Alzheimer's disease and hereditary frontotemporal dementia.
  • HY-173291
    Tau ligand-1
    		Ligand
    Tau ligand-1 (Compound 75) is a ligand for aggregated tau protein that can penetrate the blood-brain barrier. In tissues from patients with Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and Pick's disease, Tau ligand-1 exhibits high affinity for aggregated tau protein, with equilibrium dissociation constant (KD) values ranging from 1 to 3.8 nM. Tau ligand-1 can serve as a potential positron emission tomography (PET) tracer and holds promise for application in positron emission tomography imaging studies of tau-related diseases in the central nervous system.
  • HY-W338446
    BF-170
    		Ligand
    BF-170 is a selective tau fibril binding agent with an EC50 of 221 nM. It exhibits good blood-brain barrier permeability, and after intravenous injection in mice, the concentration in brain tissue reaches 9.1% ID/g within 2 minutes (with a brain clearance rate of 0.25% ID/g after 30 minutes). BF-170 can be used as a probe for tau protein pathology imaging in Alzheimer's disease (AD). It plays an important role in early-stage AD research and holds potential for imaging studies of tau-related neurodegenerative diseases.