2. Signaling Pathways
  3. GPCR/G Protein
  4. Platelet-activating Factor Receptor (PAFR)

Platelet-activating Factor Receptor (PAFR)

The platelet-activating factor receptor (PAFR) is a G-protein-coupled receptor involved in both normal physiological and numerous pathophysiological processes. PAFR responds to platelet-activating factor (PAF), a phospholipid mediator of cell-to-cell communication that exhibits diverse physiological effects. Stimulation of the PAFR via binding of platelet-activating factor (PAF) elicits diverse and potent biological activities and plays a profound role in acute inflammation, allergic disorders, endotoxic shock, and anaphylaxis. PAF is a potent and versatile mediator of inflammation that is produced by numerous cell types and tissues, and particularly by leukocytes.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N11920
    Kadsurenin B
    		Antagonist
    Kadsurenin B is a PAF (platelet-activating factor) antagonist with neuroprotective activity. Kadsurenin B has a wide range of pharmacological research potential, such as antibacterial, anti-inflammatory, neuroprotective, antioxidant, antiplatelet aggregation, cytotoxic, antiparasitic, etc.
    Kadsurenin B
  • HY-19121
    TCV-309
    		Antagonist
    TCV-309 is an antagonist for platelet activating factor (PAF). TCV-309 improves the left ventricular function during ischemia-reperfusion (77.6% recover at 1 μM), protects the cardiac function.
    TCV-309
  • HY-176466
    ST-899
    		Agonist
    ST-899 is a novel platelet-activating factor (PAF) receptor antagonist. ST-899 can significantly reduce the mortality of mice with endotoxin (LPS)-induced shock. ST-899 can significantly inhibit the increase in serum tumor necrosis factor (TNF) levels induced by LPS, but has no effect on interleukin-6 (IL-6). The regulatory mechanism of ST-899 is to block the positive feedback loop between PAF and TNF, thereby reducing the inflammatory response. ST-899 can be used to study inflammatory diseases such as septic shock.
    ST-899
  • HY-134235
    PAF C-16 carboxylic acid
    PAF C-16 carboxylic acid (Acetyl-CPGPC) is a phospholipid that possesses haptenic activity causing production of antibodies reactive with platelet-activating factor (PAF).
    PAF C-16 carboxylic acid
  • HY-101594
    Tulopafant
    Tulopafant is a platelet activating factor (PAF) antagonist.
    Tulopafant
  • HY-19097
    Ro-24-4736
    Ro 24-4736 is a potent, selective, p.o.-active platelet-activating factor (PAF) antagonist with a long duration of action. Ro-24-4736 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Ro-24-4736
  • HY-19084
    Ro-24-0238
    Ro-24-0238 is an antagonist of platelet activating factor (PAF) and inhibitor of thromboxane synthesis, used for lessening the inflammation and damage resulting from a local release of PAF.
    Ro-24-0238
  • HY-113635
    ONO-6240
    		Antagonist
    ONO-6240 is a platelet-activating factor antagonist. ONO-6240 prevents EOS infiltration into airway. ONO-6240 can be used in the study of asthmatic.
    ONO-6240
  • HY-123397
    SCH-44643
    		Antagonist
    SCH-44643 is an orally active platelet activating factor (PAF) and histamine antagonist.
    SCH-44643
  • HY-N14934
    Aggreceride C
    		Inhibitor
    Aggreceride C is a platelet aggregation inhibitor. Aggreceride C shows an inhibitory activity against aggregation induced by Adenosine 5'-diphosphate (ADP) (HY-W010918), Arachidonic acid (HY-109590) and PAF (platelet activating factor), but was less active against aggregation induced by collagen.
    Aggreceride C
  • HY-100153
    48740 RP
    48740 RP ((Rac)-RP-55778) is a platelet-activating factor (PAF) antagonist.
    48740 RP
  • HY-U00040
    PAF-AN-1
    PAF-AN-1 is a platelet activating factor receptor (PAF) antagonist.
    PAF-AN-1
Cat. No. Product Name / Synonyms Application Reactivity