2. Signaling Pathways
  3. Mitosis

Mitosis

Cellular mitosis is a highly regulated and complex process involving the synergistic action of multiple proteins and molecular mechanisms. The process of mitosis is usually related to tubulin, and mitotic inhibitors can disrupt the polymerization and depolymerization of tubulin, so that chromosomes cannot be properly separated, leading to apoptosis.

Mitosis Related Products (91):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-101071
    (S)-Monastrol
    		Inhibitor
    (S)-Monastrol ((+)-Monastrol) is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cancer cell lines. (S)-Monastrol arrests mammalian cells in mitosis with monopolar spindles.
    (S)-Monastrol
  • HY-13627A
    Estramustine phosphate
    		Inhibitor
    Estramustine phosphate, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine phosphate depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine phosphate can interfere mitosis, trigger cell death and induce apoptosis, which can be used for the research of cancer like prostate cancer.
    Estramustine phosphate
  • HY-164501
    Mps-BAY1
    		Activator
    Mps-BAY1 is an MPS1 inhibitor with anticancer activity. Mps-BAY1 inhibits cell proliferation and induces apoptosis by activating mitotic catastrophe in cancer cells, generating global aneuploidy and polyploidy. Mps-BAY1 can be used in the study of colorectal cancer and cervical cancer.
    Mps-BAY1
  • HY-129727
    (E)-MS0019266
    		Inhibitor
    (E)-MS0019266 is a potent inhibitor of DNA damage repair. (E)-MS0019266 inhibits ribonucleotide reductase by generating reactive oxygen species. (E)-MS0019266 also reduces expression of genes related to cell cycle arrest and mitosis, including polo-like kinase 1, kinesin family member 20a, cyclin B1 and aurora kinase A. (E)-MS0019266 is promising for research of inhibitors of ribonucleotide reductase and polo-like kinase 1.
    (E)-MS0019266
  • HY-107811A
    Harmol hydrochloride
    		Inducer
    Harmol hydrochloride is an orally active β-carboline alkaloid. Harmol hydrochloride is a TFEB activator and monoamine oxidase inhibitor. Harmol hydrochloride can induce cell mitosis, Autophagy and Apoptosis. Harmol hydrochloride promotes the degradation of α-synuclein by regulating the autophagy-lysosomal pathway. Harmol hydrochloride has anti-tumor, anti-depressant and anti-aging activities. Harmol hydrochloride improves motor impairment in a mouse Parkinson's disease model.
    Harmol hydrochloride
  • HY-P10119
    PDGFR Y1021 peptide (non-phosphorylation)
    		Inhibitor
    PDGFR Y1021 peptide (non-phosphorylation) is the non-phosphorylated fragment of platelet-derived growth factor receptor (PDGFR). PDGFR Y1021 peptide (non-phosphorylation) blocks the PLCγ association to PDGFR through PLCγSH2 domain, and thus inhibits mitogenic response.
    PDGFR Y1021 peptide (non-phosphorylation)
  • HY-16036A
    ALB-109564 hydrochloride
    		Inhibitor
    ALB-109564 (12'-Methylthiovinblastine) hydrochloride, a tubulin inhibitor, is a cytotoxic agent designed to kill cancer cells by disrupting mitosis.
    ALB-109564 hydrochloride
  • HY-13589A
    Cemadotin hydrochloride
    		Inhibitor
    Cemadotin (LU103793) hydrochloride is a water-soluble synthetic analogue of Dolastatin 15 (HY-P1126) that inhibits cell proliferation in vitro and the growth of tumor xenografts in mice. Cemadotin hydrochloride blocks cells at mitosis, and exhibits Ki value of 1 μM for inhibiting tubulin. Cemadotin hydrochloride can be used to research anticancer.
    Cemadotin hydrochloride
  • HY-129288
    GW837016X
    		Inhibitor
    GW837016X (NEU-391) is an orally active ErbB-2 kinase covalent inhibitor. GW837016X also is a potent antitrypanosome agent. GW837016X inhibits mitosis and cytokinesis.
    GW837016X
  • HY-156958
    S-72
    		Inhibitor
    S-72 inhibits tubulin polymerization and further triggers mitosis-phase cell cycle arrest and cell apoptosis, in addition to suppressing STAT3 signaling.
    S-72
  • HY-134061
    Arecaidine propargyl ester hydrobromide
    		Inhibitor
    Arecaidine propargyl ester hydrobromide is an agonist of M2 muscarinic acetylcholine receptors and has the activity of inhibiting tumor cell proliferation. The application of arecaidine propargyl ester hydrobromide has shown that it can reduce the number of ovarian cancer cells in vitro and induce apoptosis and the production of reactive oxygen species (ROS) at specific concentrations. Arecaidine propargyl ester hydrobromide can also arrest cells at the G2/M phase of the cell cycle and increase the percentage of abnormal mitosis. Arecaidine propargyl ester hydrobromide is more sensitizing to ovarian surface epithelial cells with higher M2 receptor levels than to cancer cells. Arecaidine propargyl ester hydrobromide exhibits the effect of lowering arterial blood pressure when interacting with the cardiovascular system in a natural physiological state, indicating its potential pharmacological application.
    Arecaidine propargyl ester hydrobromide
  • HY-136369
    Ethofumesate
    		Inhibitor
    Ethofumesate, a chiral herbicide, acts by inhibiting mitosis and reducing photosynthesis and plant respiration.
    Ethofumesate
  • HY-129715
    MPI-0441138
    		Inhibitor
    MPI-0441138 is an inducer of apoptosis and an inhibitor of mitosis. MPI-0441138 can induce DNA breaks and induce cytochrome c translocation, leading to tumor cell death.
    MPI-0441138
  • HY-B2062R
    Chlorthal-dimethyl (Standard)
    		Inhibitor
    Chlorthal-dimethyl (Standard) is the analytical standard of Chlorthal-dimethyl. This product is intended for research and analytical applications. Chlorthal-dimethyl (Dimethyl tetrachloroterephthalate) is a plant growth regulator. Chlorthal-dimethyl affects cell division and differentiation, interfering with the normal development of vascular tissue. Chlorthal-dimethyl causes localized swelling of tomato hypocotyls and disrupts normal mitosis in germinating millet seedlings.
    Chlorthal-dimethyl (Standard)
  • HY-124761
    Poloppin
    		Inhibitor
    Poloppin is a potent, cell penetrant inhibitor of the mitotic Polo-like kinase (PLK) (IC50=26.9 μM) and prevents the protein-protein interaction via the Polo-box domain (PBD) (Kd= 29.5 μM). Poloppin selectively kills cells expressing mutant KRAS, enhancing death in mitosis. Poloppin is used for the study of KRAS-mutant cancers as single agents, or in combination with c-MET inhibitors.
    Poloppin
  • HY-118327
    Maleuric acid
    		Inhibitor
    Maleuric acid has cytotoxicity on Ehrlich ascites tumor cells by preventing the entry of preprophase cells into mitosis[1].
    Maleuric acid
  • HY-169581
    DIM-C-pPhtBu
    		Inducer
    DIM-C-pPhtBu is an orally active endoplasmic reticulum stress activator. DIM-C-pPhtBu induces mitochondrial and lysosome dysfunction, excessive mitosis, ROS production, and unfolded protein response-mediated cell death in neck cancer cells. DIM-C-pPhtBu has antitumor activity.
    DIM-C-pPhtBu
  • HY-12797
    GF 15
    		Inhibitor
    GF 15 is an inhibitor of centrosomal clustering during cell mitosis, with an EC50 value of 900 nM for inducing multipolar spindles. GF 15 is a derivative of griseofulvin that inhibits tubulin polymerization at concentrations above 25 μM. GF 15 inhibits tumor growth and significantly prolongs survival in mouse xenograft models of human colon cancer and multiple myeloma.
    GF 15
  • HY-NP187
    Phytolacca americana Lectin
    		Inducer
    Phytolacca americana Lectin (PWM) is a lectin that specific for N-acetylglucosamine-containing saccharides. Phytolacca americana Lectin stimulates peripheral lymphocytes to undergo mitosis by binding to their cell surfaces. Phytolacca americana Lectin can be used as a probe to specifically bind to biological molecules. Phytolacca americana Lectin is a biomaterial or organic compound that can be used in life science research.
    Phytolacca americana Lectin
  • HY-124790
    KSP-IA
    		Inhibitor
    KSP-IA (compound 17) is a potent kinesin spindle protein (KSP) inhibitor with an IC50 value of 3.6 nM. KSP-IA inhibits cell mitosis.
    KSP-IA