2. Signaling Pathways
  3. Mitosis

Mitosis

Cellular mitosis is a highly regulated and complex process involving the synergistic action of multiple proteins and molecular mechanisms. The process of mitosis is usually related to tubulin, and mitotic inhibitors can disrupt the polymerization and depolymerization of tubulin, so that chromosomes cannot be properly separated, leading to apoptosis.

Mitosis Related Products (91):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-124757
    FiVe1
    		Inhibitor 99.87%
    FiVe1 is a potent vimentin (VIM; the intermediate filament and mesenchymal marker) inhibitor. FiVe1 promotes VIM disorganization and phosphorylation during metaphase, leading to mitotic catastrophe, multinucleation, and the loss of stemness. FiVe1 selectively and irreversibly inhibits the growth of multiple FOXC2-expressing breast cancer cell lines (HMLER cells (IC50: 267 nM); FOXC2-HMLER cells (IC50: 447 nM). FiVe1 inhibits the migration of mesenchymally transformed cells.
    FiVe1
  • HY-13224
    AZD4877
    		Inhibitor 99.49%
    AZD4877 is another isostere to Ispinesib (HY-50759)and also a kinesin spindle protein (Eg5) inhibitor with IC50 of 2 nM.AZD4877 arrests cell mitosis, leads to the formation of the monopolar spindle phenotype and induces apoptosis. AZD4877 inhibits circulating peripheral blood mononuclear cells (PBMCs) and has anti-cancer activity.
    AZD4877
  • HY-150084
    (±)14,15-Epoxyeicosatrienoic acid
    		Activator ≥99.0%
    (±)14,15-Epoxyeicosatrienoic acid ((±)14(15)-EET) is the Cytochrome P450 metabolite of arachidonic acid. While CYP3A4 may be involved in breast cancer cell growth, (±)14,15-Epoxyeicosatrienoic acid may promote mitosis and anchorage-dependent cloning through STAT3 affected by CYP3A4. (±)14,15-Epoxyeicosatrienoic acid exhibits STAT3-dependent cell growth promotion and may also participate in the autocrine/paracrine pathway that drives cell growth.
    (±)14,15-Epoxyeicosatrienoic acid
  • HY-153384
    EAPB 02303
    		Inhibitor 99.39%
    EAPB 02303 is a microtubule-disrupting agent and inhibitor. EAPB 02303 induces mitosis arrest and impairment of spindle assembly. Thus, EAPB 02303 induces apoptosis and exhibits antitumor activity. EAPB 02303 also exhibits a potent synergy with Paclitaxel (HY-B0015) at lower concentrations.
    EAPB 02303
  • HY-103711
    Estramustine
    		Inhibitor 99.03%
    Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding to tubulin 1, exhibits antimitotic activity with an IC50 value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts.
    Estramustine
  • HY-138084
    SIC5-6
    		Modulator 99.82%
    SIC5-6 is a potent Separase inhibitor. Separase, a large cysteine protease, involves in chromosome segregation during mitosis and meiosis, DNA damage repair, centrosome disengagement and duplication, spindle stabilization and elongation. Separase is highly overexpressed in many solid cancers, serves as an attractive chemotherapeutic target.
    SIC5-6
  • HY-13647
    HMN-176
    		Inhibitor 98.84%
    HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1), without significant effect on tubulin polymerization.
    HMN-176
  • HY-33046A
    N-Boc-dolaproine dicyclohexylamine
    		Inhibitor 99.92%
    N-Boc-dolaproine dicyclohexylamine is an amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity. And contains dicyclohexylamine.
    N-Boc-dolaproine dicyclohexylamine
  • HY-43304
    N-Boc-dolaproine-methyl
    		Inhibitor 98.23%
    N-Boc-dolaproine-methyl is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity.
    N-Boc-dolaproine-methyl
  • HY-13737
    R1530
    		Inhibitor 99.06%
    R1530 is a highly potent, orally active, dual-acting mitosis/angiogenesis inhibitor, with anti-tumor and anti-angiogenic activities. R1530 is a multikinase inhibitor which binds to 31 kinases with Kd values of <500 nM. R1530 inhibits VGFR2 and FGFR1 with IC50 of 10 nM and 28 nM, respectively. R1530 triggers apoptosis (mitotic catastrophe) or senescence.
    R1530
  • HY-13691
    MKC-1
    		Inhibitor 99.78%
    MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family.
    MKC-1
  • HY-156437
    NBI-961
    		Inhibitor 99.73%
    NBI-961 is a potent NEK2 inhibitor that inhibits proteasomal degradation. NBI-961 induces G2/mitosis arrest and apoptosis in diffuse large B cell lymphoma (DLBCL) cells.
    NBI-961
  • HY-147006
    Zovodotin
    		Inhibitor 99.79%
    MT-VC-ZD02044 is a cytotoxic and anti-mitotic agent.
    Zovodotin
  • HY-P3840
    Head activator neuropeptide
    		Activator 99.50%
    Head activator neuropeptide is a mitogen for mammalian cell lines of neuronal or neuroendocrine origin. Head activator neuropeptide signals by binding GPR37 and stimulates cells to enter mitosis.
    Head activator neuropeptide
  • HY-12564
    Phthalazinone pyrazole
    		Inhibitor ≥98.0%
    Phthalazinone pyrazole is a potent, selective, and orally active inhibitor of Aurora-A kinase with an IC50 of 0.031 μM. Phthalazinone pyrazole can arrests mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells. Phthalazinone pyrazole suppresses the epithelial-mesenchymal transition (EMT) during the differentiation of hepatocyte-like cells (HLCs) from human embryonic stem cells.
    Phthalazinone pyrazole
  • HY-111425
    SSE15206
    		Inhibitor 99.88%
    SSE15206 is a microtubule polymerization inhibitor (GI50 = 197 nM in HCT116 cells) that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells.
    SSE15206
  • HY-100368
    MELK-8a
    		Modulator 98.32%
    MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC50 of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC50s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells.
    MELK-8a
  • HY-B2062
    Chlorthal-dimethyl
    		Inhibitor 98.69%
    Chlorthal-dimethyl (Dimethyl tetrachloroterephthalate) is a plant growth regulator. Chlorthal-dimethyl affects cell division and differentiation, interfering with the normal development of vascular tissue. Chlorthal-dimethyl causes localized swelling of tomato hypocotyls and disrupts normal mitosis in germinating millet seedlings.
    Chlorthal-dimethyl
  • HY-W014240
    Chlorpropham
    		Inhibitor
    Chlorpropham is a carbamate herbicide and plant growth regulator. Chlorpropham inhibits mitosis and cell division by interfering with the organisation of the spindle microtubules.
    Chlorpropham
  • HY-158038
    AurkA allosteric-IN-1
    		Modulator
    AurkA allosteric-IN-1 (compound 6h) is an Aurora A (AurkA) inhibitor (IC50: 6.50 μM) that inhibits the catalytic activity and non-catalytic functions of Aurora A. Aurora A regulates the assembly of the bipolar mitotic spindle and the fidelity of chromosome segregation during mitosis and has non-catalytic functions. AurkA allosteric-IN-1 blocks the interaction of AurkA with the activator TPX2 by binding to the Y pocket of AurkA.
    AurkA allosteric-IN-1