Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Inhibitor (1)

Isotope-Labeled Compounds Related Products (7665):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-15287S

Nelfinavir-d₃
Nelfinavir-d₃ (AG1341-d3) is the deuterium labeled Nelfinavir. Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent[1][2][3].

HY-W705651

Econazole nitrate-d₆
Econazole nitrate-d₆ is deuterium labeled Econazole (nitrate). Econazole nitrate is an imidazole class antifungal medication. Econazole nitrate also has antibacterial activity.

HY-14566S3

Donepezil-d₄
Donepezil-d₄ (E2020-d₄ (free base)) is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC₅₀s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively.

HY-W101987S1

Bisphenol A bis(2,3-dihydroxypropyl) ether-d₁₄
Bisphenol A bis(2,3-dihydroxypropyl) ether-d₁₄ is deuterium labeled 3,3'-((Propane-2,2-diylbis(4,1-phenylene))bis(oxy))bis(propane-1,2-diol).

HY-103414S

Raclopride-d₅ hydrochloride		99.82%
Raclopride-d₅ (hydrochloride) is the deuterium labeled Raclopride. Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively[1][2].

HY-W028943S

(E)-3-Methyl-2-hexenoic acid-d₅
(E)-3-Methyl-2-hexenoic acid-d5 ((2E)-3-Methyl-2-hexenoic acid-d5) is a deuterium labeled (E)-3-Methyl-2-hexenoic acid. (E)-3-Methyl-2-hexenoic acid is an axillary odor-related compound.

HY-W011303S

Phytosphingosine-d₇
Phytosphingosine-d₇ (4-Hydroxysphinganine-d₇) is deuterium labeled Phytosphingosine. Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes.

HY-W013214S

Ethyl arachidonate-d₁₁
Ethyl arachidonate-d₁₁ is deuterium labeled Ethyl arachidonate. Ethyl arachidonate is a lipophilic esterified form of arachidonic acid (AA) and can be added into dietary regimens or fed to cultured cells as a source of exogenous arachidonate. Ethyl arachidonate is the main species of fatty acid ethyl esters (FAEE) in brain of alcohol-intoxicated subjects.

HY-15027S4

5-Aminosalicylic acid-d₇
5-Aminosalicylic acid-d₇ (5-ASA-d₇; Mesalamie-d₇; Mesalazie-d₇) is deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).

HY-12767S2

Carvedilol metabolite 4-Hydroxyphenyl Carvedilol-¹³C₆
Carvedilol metabolite 4-Hydroxyphenyl Carvedilol-¹³C₆ (4-Hydroxycarvedilol Carvedilol-¹³C₆) is ¹³C labeled Carvedilol metabolite 4-Hydroxyphenyl Carvedilol.

HY-W016481S

4-Methoxybenzyl acetate-d₃
4-Methoxybenzyl acetate-d₃ is deuterated labeled cis-3-Hexenyl Acetate.

HY-113486S

(S)-Lathosterol-d₄		99.70%
(S)-Lathosterol-d₄ is the deuterium labeled (S)-Lathosterol. Lathosterol is a cholesterol-like molecule. Serum Lathosterol concentration is an indicator of whole-body cholesterol synthesis[1].

HY-167587S

1-Heptadecanoyl-2-eicosatrienoyl-sn-glycero(-d₅)-3-phosphocholine
1-Heptadecanoyl-2-eicosatrienoyl-sn-glycero(d₅)-3-phosphocholine is deuterium labeled 1-Heptadecanoyl-2-eicosatrienoyl-sn-glycero-3-phosphocholine.

HY-W779193

2-Amino-3-methyl-3H-imidazo[4,5-f]quinoline-2-¹³C
2-Amino-3-methyl-3H-imidazo[4,5-f]quinoline-2-¹³C is ¹³C labeled 2-Ammo-3-memyl-imidazo-[4,5-f]-quinoIine. 2-Ammo-3-memyl-imidazo-[4,5-f]-quinoIine is a mutagenic compound.

HY-W654156

Diclazuril-¹³C₃,¹⁵N₂
Diclazuril-¹³C₃,¹⁵N² is ¹³C and ¹⁵N labeled Diclazuril. Diclazuril (R-64433), a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al.

HY-105182S1

Xanomeline-d₃
Xanomeline-d₃ (LY-246708-d₃) is deuterium labeled Xanomeline. Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia.

HY-118759S

DSP Crosslinker-d₈
DSP Crosslinker-d₈ is the deuterium labeled DSP Crosslinker. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified.

HY-165698S

Flupyrsulfuron-methyl-d₆ sodium
Flupyrsulfuron-methyl-d₆ (sodium) is deuterium labeled Flupyrsulfuron-methyl (sodium).

HY-15448S1

Tezacaftor-d₆
Tezacaftor-d₆ (VX-661-d₆) is deuterium labeled Tezacaftor. Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation.

HY-B0368S1

Captopril-¹³C₅,¹⁵N
Captopril-¹³C₅,¹⁵N (SQ 14225-¹³C₅,¹⁵N) is ¹³C and ¹⁵N labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM.

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