Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Inhibitors (2)

Isotope-Labeled Compounds Related Products (9621):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-14302S1

Salmeterol-d₅
Salmeterol-d5 is a deuterated labeled Salmeterol. Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively.

HY-128753S4

D-Lyxose-¹³C-3
D-Lyxose-¹³C-3 is the ¹³C labeled D-Lyxose. D-Lyxose is an endogenous metabolite.

HY-W777534

4-Acetamidobenzene-1-sulfonyl chloride-¹³C₆
4-Acetamidobenzene-1-sulfonyl chloride-¹³C₆ (N-Acetylsulfanilyl chloride-¹³C₆) is the ¹³C-labeled 4-Acetamidobenzene-1-sulfonyl chloride (HY-W012207).

HY-N0379S15

D-mannose-d₇
D-mannose-d₇ is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote.

HY-W010249S

D-α-Phenyl-glycine-d₅		≥99.0%
D-α-Phenyl-glycine-d₅ is the deuterium labeled D-α-Phenyl-glycine.

HY-17595S1

Mebendazole-d₈
Mebendazole-d₈ is the deuterium labeled Mebendazole. Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations; has been found as a hedgehog inhibitor.

HY-112094S

WNK-IN-11-d₃		99.84%
WNK-IN-11-d₃ is an orally active, selective and potent With-No-Lysine (WNK) kinase inhibitor. WNK-IN-11-d₃ is effective at regulating cardiovascular homeostasis.

HY-B0168AS

Milnacipran-d₅ hydrochloride
Milnacipran-d₅ hydrochloride is deuterium labeled Milnacipran hydrochloride (HY-B0168A). Milnacipran hydrochloride is an orally active Serotonin (HY-B1473A) and Norepinephrine (HY-13715) reuptake inhibitor. Milnacipran hydrochloride inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter (K_i values of 31 and 8.5 nM, respectively). Milnacipran hydrochloride inhibits pERK1/2 activation. Milnacipran hydrochloride has antidepressant, anxiolytic and analgesic properties. Milnacipran hydrochloride inhibits biting behavior in mice. Milnacipran hydrochloride can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia).

HY-W707394

NOBA-d₁₅
NOBA-d₁₅ is the deuterium labeled NOBA (HY-137799). NOBA is a synthetic chromogenic substrate that can be used to detect the enzyme activity of AplTX-II. NOBA can be used in the research of phospholipid hydrolysis.

HY-W768181

1,5-Anhydrosorbitol-¹³C₆
1,5-Anhydrosorbitol-¹³C₆ (1,5-Anhydro-D-glucitol-¹³C₆) is the ¹³C-labeled 1,5-Anhydrosorbitol (HY-113075). 1,5-Anhydrosorbitol is a short-term marker for glycemic control.

HY-W768439

Diosmetin 7-O-β-D-Glucuronide-d₃ Sodium Salt
Diosmetin 7-O-β-D-Glucuronide-d₃ Sodium Salt is the deuterium labeled Diosmetin 7-O-β-D-Glucuronide Sodium Salt.

HY-W142434S

D-Galactose-¹³C-1		99.9%
D-Galactose-¹³C-1 is the ¹³C labeled D-galactopyranose.

HY-105853S

Pitofenone-d₄
Pitofenone-d₄ is deuterium labeled Pitofenone (HY-105853). Pitofenone, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with K_is of 36 and 45 μM, respectively.

HY-W706083

N-(4-hydroxycyclohexyl)acetamide-d₁₀
N-(4-hydroxycyclohexyl)acetamide-d₁₀ is the deuterium labeled N-(4-hydroxycyclohexyl)acetamide (HY-W078945).

HY-B0731AS

Perospirone-d₈
Perospirone-d₈ (SM-9018-d₈ (free base)) is deuterium labeled Perospirone. Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT_2A receptor (K_i=0.6 nM) and dopamine D₂ receptor (K_i=1.4 nM), and also a partial agonist of 5-HT_1A receptor (K_i=2.9 nM). Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research.

HY-W766964

3,5-Di-O-p-chlorobenzoyl Floxuridine-¹³C,¹⁵N₂
3,5-Di-O-p-chlorobenzoyl Floxuridine-¹³C,¹⁵N₂ is the ¹³C- and ¹⁵N-labeled 3,5-Di-O-p-chlorobenzoyl Floxuridine (HY-W778028).

HY-B2176S3

ATP-¹⁵N₅,d₁₄ dilithium		98%
ATP-¹⁵N₅,d₁₄ (Adenosine 5'-triphosphate-¹⁵N₅,d₁₄) dilithium is deuterium and ¹⁵N labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.

HY-W098697S

Dimethyldithiocarbamate-d₆ sodium dihydrate
Dimethyldithiocarbamate-d₆ sodium dihydrate is the deuterium-labeled Dimethyldithiocarbamate (HY-W098697). Ferric dimethyl‐dithiocarbamate (ferbam) exhibits oral toxicity in rodents.

HY-34740S1

Ethylmalonic acid-d₅		98.09%
Ethylmalonic acid-d₅ is the deuterium labeled Ethylmalonic acid (HY-34740). Ethylmalonic acid is a short-chain organic dicarboxylic acid. Ethylmalonic acid synergistically induces mitochondrial permeability transition (MP) with Ca²⁺, inhibits Mi-CK, and disrupts mitochondrial energy metabolism. Ethylmalonic acid can be used in the research of SCADD, EE and other genetic metabolic diseases characterized by EMA accumulation.

HY-B0286AS

Chlorpheniramine-d₄ maleate
Chlorpheniramine-d₄ (maleate) is deuterium labeled Chlorpheniramine (maleate).

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