Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Inhibitors (4)

Isotope-Labeled Compounds Related Products (9689):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-17038S

Agomelatine-d₆		98.57%
Agomelatine-d₆ is deuterium labeled Agomelatine. Agomelatine is a specific agonist of MT1 and MT2 receptors .

HY-10569S1

Ponesimod-d₇
Ponesimod-d₇ (ACT-128800-d₇) is the deuterium-labeled Ponesimod (HY-10569). Ponesimod-d₇ (ACT-128800) is a potent, selective and orally active agonist of S1P₁, with an IC₅₀ of 6 nM in a radioligand binding assay. Ponesimod-d₇ activates S1P₁-mediated signal transduction with high potency (EC₅₀=5.7 nM). Ponesimod-d₇ can protect against lymphocyte-mediated tissue inflammation.

HY-W009762S2

L-Lysine-d₄ dihydrochloride		≥98.0%
L-Lysine-d₄ (dihydrochloride) is the deuterium labeled L-Lysine dihydrochloride.

HY-136648S1

2'-Deoxyadenosine-5'-triphosphate-¹³C₁₀,¹⁵N₅ dilithium		99.2%
2'-Deoxyadenosine-5'-triphosphate-¹³C₁₀,¹⁵N₅ (dATP-¹³C₁₀,¹⁵N₅) dilithium is ¹³C and ¹⁵N-labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.

HY-50904S1

Nintedanib-¹³C,d₃		≥99.0%
Nintedanib-¹³C,d₃ is the ¹³C- and deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

HY-B0507S

Sulfathiazole-d₄		99.91%
Sulfathiazole-d₄ is a deuterium labeled Sulfathiazole. Sulfathiazole is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRN expression of CYP17, CYP19, and 3β-HSD. Sulfathiazole increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish.

HY-143915S

Amitriptyline-N-glucuronide-d₃
Amitriptyline-N-glucuronide-d₃ is the deuterium labeled Amitriptyline-N-glucuronide.

HY-N0092S

Inosine-2,8-d₂		99.69%
Inosine-2,8-d₂ is the deuterium labeled Inosine. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors.

HY-N1131S

Triacetonamine-d₁₇		99.72%
Triacetonamine-d17 (2,2,6,6-Tetramethyl-4-piperidone-d17) is the deuterium labeled Triacetonamine. Triacetonamine has oral activity and can induce acute liver failure (ALF) in rats.

HY-17395S

Terbinafine-d₃ hydrochloride		99.87%
Terbinafine-d₃ hydrochloride is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a K_i of 30 nM. Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria.

HY-N0210S

D-Galactose-¹³C		≥98.0%
D-Galactose-¹³C is the ¹³C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.

HY-30004S

1-Aminocyclopropane-1-carboxylic acid-d₄		≥99.0%
1-Aminocyclopropane-1-carboxylic acid-d₄ is the deuterium labeled 1-Aminocyclopropane-1-carboxylic acid. Aminocyclopropane-1-carboxylic acid is an endogenous metabolite[1].

HY-N7143S

Monobutyl phthalate-d₄		99.34%
Monobutyl phthalate-d₄ is the deuterium labeled Monobutyl phthalate. Monobutyl phthalate, a major metabolite of dibutyl phthalate (DBP), possesses antiandrogenic effects. Monobutyl phthalate is an embryotoxicant.

HY-W127841

Citric acid-2,4-¹³C₂		98.00%
Citric acid-2,4-¹³C₂ is the ¹³C-labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries.

HY-10863S

Anandamide-d₈		99.90%
Anandamide-d8 is a deuterated labeled Anandamide. Anandamide is an endocannabinoid. Anandamide modulates both neuronal and immune functions through two protein-coupled cannabinoid receptors (CB1 and CB2). Anandamide can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55. Anandamide also has potential anti-fungal and anti-inflammatory activities. Anandamide can be used for the research of Alzheimer’s disease (AD) and ulcerative colitis.

HY-137083S

Trifluoperazine N-glucuronide-d₃
Trifluoperazine N-glucuronide-d₃ is deuterium labeled Trifluoperazine N-Glucuronide. Trifluoperazine N-Glucuronide (UGT1A4), as one of the human UGT1A isoforms, is expressed in the liver. Trifluoperazine N-Glucuronide catalyzes the imipramine and trifluoperazine Nglucuronide formation.

HY-Y1250S2

Fmoc-Gly-OH-2,2-d₂		99.66%
Fmoc-Gly-OH-2,2-d₂ is the deuterium labeled Fmoc-Gly-OH-2,2.

HY-B0456S3

Riboflavin-d₃		99.40%
Riboflavin-d₃ is the deuterium labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.

HY-B0493S1

Niflumic acid-¹³C₆		99.8%
Niflumic acid-¹³C₆ is the ¹³C₆ labeled Niflumic acid. Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.

HY-B0451AS1

Dopamine-¹³C₆ hydrochloride		98.71%
Dopamine-¹³C₆ (hydrochloride) is the ¹³C labeled Dopamine hydrochloride (ASL279).

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