Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Inhibitors (4)

Isotope-Labeled Compounds Related Products (9692):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-145119S

Mindeudesivir		99.02%
GS-621763-d₁ is the deuterium labeled GS-621763 (HY-145119). GS-621763, an orally bioavailable proagent of GS-441524, shows antiviral activity against SARS-CoV-2 pathogenesis in mice.

HY-17508S

Clarithromycin-¹³C,d₃		≥99.0%
Clarithromycin-¹³C,d₃ is the deuterium and ¹³C labeled Clarithromycin.

HY-13585S

Carmustine-d₈		98.34%
Carmustine-d₈ is the deuterium labeled Carmustine. Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA.

HY-15780S

Brexpiprazole-d₈		≥99.0%
Brexpiprazole-d₈ (OPC-34712-d₈) is the deuterium labeled Brexpiprazole (HY-15780). Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D_2L receptor with K_is of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a K_i of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (K_i=0.17 nM) and α2C receptors (K_i=0.59 nM)^.

HY-N8015S

Octanal-d₁₆
Octanal-d₁₆ is the deuterium labeled Octanal. Octanal is a fragrant aldehyde with antioxidant and antibacterial activity. Its antifungal effect against G. citri-aurantii may be related to the disruption of cell membrane integrity and the leakage of cellular components. Additionally, Octanal exhibits cytotoxicity towards HeLa cells, with an IC₅₀ value of 3.5 μg/mL.

HY-B0656S

Rabeprazole-d₄
Rabeprazole-d₄ is a deuterium labeled Rabeprazole. Rabeprazole is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC₅₀ of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux.

HY-14539S2

Clozapine-d₄		99.82%
Clozapine-d₄ is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors.

HY-Y1039S1

1-Stearoyl-rac-glycerol-d₃₅		99.04%
1-Stearoyl-rac-glycerol-d₃₅ is the deuterium labeled 1-Stearoyl-rac-glycerol.

HY-76847S3

Chenodeoxycholic acid-d₅		≥98.0%
Chenodeoxycholic acid-d₅ is the deuterium labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.

HY-138616S4

dGTP-¹³C₁₀,¹⁵N₅ dilithium		98.2%
dGTP-¹³C₁₀,¹⁵N₅ (2'-Deoxyguanosine-5'-triphosphate-¹³C₁₀,¹⁵N₅) dilithium is ¹³C and ¹⁵N-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-17563S2

2'-Deoxyguanosine-¹³C₁₀		99.8%
2'-Deoxyguanosine-¹³C₁₀ (Deoxyguanosine-¹³C₁₀; Guanine deoxyriboside-¹³C₁₀) is ¹³C-labeled 2'-Deoxyguanosine (HY-17563). 2'-Deoxyguanosine (Deoxyguanosine) is deoxyguanosine.

HY-W718300

Indole-3-pyruvic acid-d₅
Indole-3-pyruvic acid-d₅ is deuterated labeled Indole-3-pyruvic acid. Indole-3-pyruvic acid, a keto analogue of tryptophan, is an orally active AHR agonist. Indole-3-pyruvic acid has antioxidant properties, and can be used in the research of inflammation, anxiety.

HY-N0097S6

Guanosine-¹³C₁₀,¹⁵N₅		99.8%
Guanosine-¹³C₁₀,¹⁵N₅ is the ¹³C and ¹⁵N labeled Guanosine (HY-N0097). Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity.

HY-14805S

Tecovirimat-d₄		99.14%
Tecovirimat-d₄ (ST-246-d₄) is a deuterium-labelled Tecovirimat (HY-14805). Tecovirimat is an orally bioavailable and selective compound against orthopoxviruses [including vaccinia, monkeypox, camelpox, cowpox, ectromelia (mousepox), smallpox and variola viruses]. Tecovirimat is evaluated against vaccinia, cowpox virus, ectromelia virus with EC₅₀ values of 0.01 μM, 0.48 μM and 0.05 μM, respectively. Tecovirimat targets the orthopoxvirus protein VP37 which is necessary for membrane envelopment of intracellular mature virus particles to form enveloped virus. Tecovirimat exerts antiviral activity on the target of the cowpox virus V061 gene, which is homologous to vaccinia virus F13L, encoding a major envelope protein (p37) required for production of extracellular virus. Tecovirimat could be used in the study for orthopoxvirus-induced diseases.

HY-I0508S

Phthalic acid-d₄		98.36%
Phthalic acid-d₄ is the deuterium labeled Phthalic acid. Phthalic acid is the final common metabolite of phthalic acid esters (PAEs). Phthalic acid can be used for the synthesis of synthetic agents, such as isophthalic acid (IPA), and terephthalic acid (TPA). Phthalic acid has applications in the preparation of phthalate ester plasticizers. Phthalic acid exhibits mutagenic effect and causes genetic damage in mammalian germ cells.

HY-Y1119S

1-Bromonaphthalene-d₇		98.91%
1-Bromonaphthalene-d₇ is the deuterium labeled 1-Bromonaphthalene.

HY-17376S

Ezetimibe-d₄		98.84%
Ezetimibe-d₄ is the deuterium labeled Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-B0144BS

Pitavastatin-d₄ sodium		99.67%
Pitavastatin-d₄ (sodium) is deuterium labeled Pitavastatin (sodium).

HY-118103S

Coprostanol-d₅		99.30%
Coprostanol-d₅ is the deuterium labeled Coprostanol.

HY-113359AS2

Uridine 5'-diphosphate-¹³C₉,¹⁵N₂ dilithium		99.5%
Uridine 5'-diphosphate-¹³C₉,¹⁵N₂ dilithium is ¹³C and ¹⁵N-labeled Uridine 5'-diphosphate (HY-113359). Uridine 5'-diphosphate is a P2Y₆ receptor agonist with an EC₅₀ of 0.013 μM for human P2Y₆ receptor.

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