Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Inhibitor (1)

Isotope-Labeled Compounds Related Products (7656):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W013049S4

Docosanoic acid-d₄-1		≥99.0%
Docosanoic acid-d₄-1 (Behenic acid-d₄-1) is the deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans.

HY-Y0262S1

Oxalic acid-¹³C₂		99.45%
Oxalic acid-¹³C₂ is the deuterium labeled Oxalic acid, 99% (HY-Y0262). Oxalic Acid is a strong dicarboxylic acid occurring in many plants and vegetables and can be used as an analytical reagent and general reducing agent.

HY-B0171S

Antipyrine-d₃		99.91%
Antipyrine-d₃ is the deuterium labeled Antipyrine. Antipyrine (Phenazone) is an antipyretic and analgesic. Antipyrine can be used as a probe agent for oxidative agent metabolism. Antipyrine has been widely used in assessment of hepatic oxidative capacity[1][2].

HY-B1732S2

DL-3-Phenylalanine-d₈		99.90%
DL-3-Phenylalanine-d₈ is the deuterium labeled DL-3-Phenylalanine[1].

HY-W004290S

Methyl heptadecanoate-d₃₃		99.04%
Methyl heptadecanoate-d₃₃ is the deuterium labeled Methyl heptadecanoate. Methyl heptadecanoate is a fatty acid methyl ester[1].

HY-B1511S

Cyclic AMP-¹³C₅
Cyclic AMP-¹³C₅ is a deuterated cyclic AMP.

HY-B1178S

(Rac)-Cotinine-d₃		99.90%
(Rac)-Cotinine-d₃ is the deuterium labeled (Rac)-Cotinine[1].

HY-W004260S1

Arachidic acid-d₃₉		98.36%
Arachidic acid-d₃₉ is the deuterium labeled Arachidic acid. Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue[1][2].

HY-B1449S10

Uridine-¹³C₅		99.90%
Uridine-¹³C₅ (β-Uridine-¹³C₅) is a ¹³C labeled Uridine (HY-B1449). Uridine (β-Uridine) is a nucleoside compound consisting of uracil and a ribose ring, which are linked by a β-N1- glycosyl bond.

HY-160144S

Lomedeucitinib		99.75%
Lomedeucitinib (BMS-986322) is a tyrosine protein kinase (TYK2) inhibitor.

HY-N0473S4

L-Tyrosine-¹³C		98.6%
L-Tyrosine-¹³C is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-W011910S

Indoxyl sulfate-d₄ potassium		98.87%
Potassium 1H-indol-3-yl sulfate-d₄ (potassium) is the deuterium labeled Potassium 1H-indol-3-yl sulfate. Potassium 1H-indol-3-yl sulfate is an endogenous metabolite.

HY-121883S

Lignoceric acid-d₄₇		98.4%
Lignoceric acid-d₄₇ is the deuterium labeled Lignoceric acid. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research[1][2].

HY-15036S

Diclofenac-d₄		99.79%
Diclofenac-d₄ is the deuterium labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-P3146S

FTISADTSK-¹³C ₆,¹⁵N₂(TFA)		99.02%
FTISADTSK-¹³C₆,¹⁵N₂ TFA is ¹³C- and ¹⁵N-labeled FTISADTSK (HY-P3146). FTISADTSK is an endogenous stable signature peptide from Trastuzumab monitored by selected reaction monitoring (SRM).

HY-W010382S

Oxaloacetic acid-¹³C₄		98.86%
Oxaloacetic acid-¹³C₄ is the ¹³C-labeled Oxaloacetic acid. Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis[1][2][3].

HY-100560S

Abscisic acid-d₆		98.69%
Abscisic acid-d₆ is deuterium labeled Abscisic acid. Abscisic acid inhibits proton pump (H⁺-ATPase).

HY-B0563S1

Ropivacaine-d₇		99.38%
Ropivacaine-d₇ is deuterium labeled Ropivacaine. Ropivacain is a potent sodium channel blocker. Ropivacain blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese[1][2]. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane[3]. Ropivacaine is used for the research of neuropathic pain management[1].

HY-W017443S

L-Asparagine-¹³C₄,¹⁵N₂ monohydrate		≥98.0%
L-Asparagine-¹³C₄,¹⁵N₂ monohydrateis the ¹³C-labeled and ¹⁵N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.

HY-W727879

Upadacitinib-¹⁵N,d₂		99.12%
Upadacitinib-¹⁵N,d₂ (ABT-494-¹⁵N,d₂) is the deuterium-labeled Upadacitinib (HY-19569). Upadacitinib-¹⁵N,d₂ (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC₅₀=43 nM). Upadacitinib-¹⁵N,d₂ (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib-¹⁵N,d₂ (ABT-494) can be used for several autoimmune disorders research.

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