GCGR

Glucagon Receptor

GCGR

Related Products

GCGR (glucagon receptor) is in the G protein-coupled receptor family, that is important in controlling blood glucose levels. The glucagon receptor is a 62 kDa protein that is activated by glucagon and is a member of the class B G-protein coupled family of receptors, coupled to G alpha i, Gs and to a lesser extent G alpha q. Stimulation of the receptor results in activation of adenylate cyclase and increased levels of intracellular cAMP. In humans, the glucagon receptor is encoded by the GCGR gene. Glucagon receptors are mainly expressed in liver and in kidney with lesser amounts found in heart, adipose tissue, spleen, thymus, adrenal glands, pancreas, cerebral cortex, and gastrointestinal tract.

GCGR Related Products (179)
Recombinant Proteins (10)
Antibodies (3)

By Effects:	Controls (4) Inhibitors (10) Agonists (88) Antagonists (32) Modulators (8)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P10019

Pegsebrenatide	Agonist
Pegsebrenatide (NLY01) is a long-acting GLP-1R agonist. Pegsebrenatide has an extended half-life and favorable blood-brain barrier penetration. Pegsebrenatide can block A1 astrocyte transformation, reducing dopaminergic cell death, and improving motor symptoms in mouse models of PD.

HY-116819A

VU0453379 hydrochloride	Modulator	≥99.0%
VU0453379 hydrochloride is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R) with an EC₅₀ of 1.3 μM.

HY-10036

Glucagon receptor antagonist-1	Antagonist	98.65%
Glucagon receptor antagonist-1 is a highly potent glucagon receptor antagonist.

HY-P3622

(Ser8)-GLP-1 (7-36) amide, human	Agonist	99.10%
(Ser8)-GLP-1 (7-36) amide, human is a glucagon-like peptide 1 amide derived from glucagonogen, a cleavage product of the GLP-1 (1-36) amide peptide. (Ser8)-GLP-1 (7-36) amide, human is an entero-insulinotropic hormone that causes glucose-dependent release of insulin from pancreatic β-cells and affects gastrointestinal motility and secretion.

HY-P5815A

GLP-1 (1-36) amide (human, rat) TFA		98.81%
GLP-1 (1-36) amide (human, rat) (Glucagon-like Peptide 1 (1-36) amide (human, rat) ) TFA is a molecular variant of glucagon-like peptide 1 (GLP-1)-(7-36) amide. GLP-1 (1-36) amide (human, rat) TFA can stimulate [14C]aminopyrine accumulation on enzymatically dispersed enriched rat parietal cells.

HY-P990013

Gulgafafusp alfa	Inhibitor
Gulgafafusp alfa is a human IgG2κ antibody targeting the glucagon-like peptide 1 receptor GLP1R.

HY-P2497

Exendin (5-39)	Antagonist	99.43%
Exendin (5-39) is a potent glucagon-like peptide 1 (GLP-1) receptor antagonist. Exendin (5-39) improves memory impairment in β-amyloid protein-treated rats.

HY-124803

GPCR modulator-1	Modulator
GPCR modulator-1 is a negative allosteric modulator of GLP receptor. GPCR modulator-1 has the potential for type 2 diabetes research.

HY-119739

Skyrin	Antagonist
Skyrin is an anthraquinone compound that can be isolated from almond fruit. Skyrin is a receptor-selective glucagon antagonist. Skyrin can inhibit the growth of tumor cells.

HY-P10031

SAR441255	Agonist	99.77%
SAR441255 is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 displays high potency with balanced activation of all three target receptors.?SAR441255 shows positive acute glucoregulatory effectss in diabetic obese monkeys.

HY-145458

GLP-1 receptor agonist 9	Agonist	99.70%
GLP-1 receptor agonist 9 is a GLP-1 receptor agonist, example 7, extracted from WO2020234726 A1.

HY-P1231

GTFTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS		99.03%
GTFTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS is an Exendin-4 peptide derivative.

HY-P1226

HAEGTFTSD	Agonist	98.48%
HAEGTFTSD is a 9-residue peptide of human GLP-1 peptide or GLP-1(7-36), amide (HY-P0054A). GLP-1(7-36), amide is a physiological incretin hormone that stimulates insulin secretionin a glucose-dependant manner

HY-P3617

Glucagon (22-29)	Agonist	99.69%
Glucagon (22-29) is partial agonist of Glucagon (19–29). Glucagon specifically inhibits the Ca²⁺ pump in liver plasma membranes independently of adenylate cyclase activation.

HY-P1224

HAEGTFTSDVS		98.62%
HAEGTFTSDVS is the first N-terminal 1-11 residues of GLP-1 peptide.

HY-P10341

ZP3022	Agonist
ZP3022 is a dual agonist of glucagon-like peptide-1 (GLP-1) and gastrin that has the ability to sustainably improve glycemic control. Additionally, ZP3022 can effectively increase β-cell mass, promote β-cell proliferation, and enhance the function of pancreatic islets. ZP3022 can be used in anti-diabetic research.

HY-147622

GLP-1R agonist 9	Agonist
GLP-1R agonist 9 (Compound 96) is a GLP-1R agonist with EC₅₀ values of 1.1 nM and 11 nM against CHO GLP-1R Clone H6 and CHO GLP-1R Clone C6, respectively.

HY-P10032

NN1177	Agonist	99.77%
NN1177 is a long-acting GLP-1/glucagon receptor co-agonist. NN1177 can induce a dose-dependent body weight loss in diet-induced obese (DIO) mice.

HY-P5815

GLP-1 (1-36) amide (human, rat)
GLP-1 (1-36) amide (human, rat) (Glucagon-like Peptide 1 (1-36) amide (human, rat) ) is a molecular variant of glucagon-like peptide 1 (GLP-1)-(7-36) amide. GLP-1 (1-36) amide (human, rat) can stimulate [14C]aminopyrine accumulation on enzymatically dispersed enriched rat parietal cells.

HY-P1227

SDV-Exendin-3/4
SDV-Exendin-3/4 is a 32-amino acid peptide.

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GCGR

GCGR

GCGR Related Products (179)

Recombinant Proteins (10)

Antibodies (3)

GCGR Related Products (179):