2. Signaling Pathways
  3. GPCR/G Protein
  4. Formyl Peptide Receptor (FPR)
  5. Formyl Peptide Receptor (FPR) Antagonist

Formyl Peptide Receptor (FPR) Antagonist

Formyl Peptide Receptor (FPR) Antagonists (9):

Cat. No. Product Name Effect Purity
  • HY-W668775
    Quin-C7
    		Antagonist
    Quin-C7 is an orally active FPR2/ALX antagonist. Quin-C7 has anti-inflammatory activity and can ameliorate DSS (HY-116282)-induced colitis in mice. Quin-C7 can be used in the research of inflammatory bowel disease.
  • HY-173591
    T0080
    		Antagonist
    T0080 is a FPR-1 antagonist. T0080 reduces the cell apoptosis, inhibits ROS production and pro-inflammatory cytokines (TNF-α and IL-1β) from plaque macrophages, which attenuates atherosclerotic progression in ApoE−/− mice.
  • HY-P1795
    Boc-dPhe-Leu-dPhe-Leu-Phe
    		Antagonist 98.91%
    N-Boc-Phe-Leu-Phe-Leu-Phe (Boc-fLfLF) is a selective N-formyl peptide receptor1 (FPR1) antagonist. N-Boc-Phe-Leu-Phe-Leu-Phe inhibits fMLF (FPR agonist)-induced superoxide production in neutrophils with an EC50of 0.25 µM. N-Boc-Phe-Leu-Phe-Leu-Phe inhibits fMIFL-induced NADPH oxidase activity. N-Boc-Phe-Leu-Phe-Leu-Phe inhibits the anti-inflammatory and antifibrotic effects of Ac2-26 (HY-P1098). N-Boc-Phe-Leu-Phe-Leu-Phe can be used for the study of immunology.
  • HY-P2355
    BOC-FlFlF
    		Antagonist 99.50%
    BOC-FlFlF (Boc-Phe-dLeu-Phe-dLeu-Phe) is a selective FPR1 antagonist. Boc-FlFlF has an apparent dissociation constant (KD) of 230 nM as determined by the intracellular calcium mobilization assay. Boc-FlFlF can be used for the study of inflammation.
  • HY-156293
    FPR1 antagonist 1
    		Antagonist
    FPR1 antagonist 1 (compound 24a) is a formyl peptide receptor 1 (FPR1) antagonist with an IC50 of 25 nM. FPR1 antagonist 1 inhibits cell growth through a combined effect on cell proliferation and apoptosis and reduces cell migration, while inducing an increase in angiogenesis.
  • HY-103473
    Boc-MLF
    		Antagonist 99.93%
    Boc-MLF is a formyl peptide receptor (FPR) antagonist, and reduces superoxide production induced by fMLF with an IC50 of 0.63 μM.
  • HY-156294
    FPR1 antagonist 2
    		Antagonist
    FPR1 antagonist 2 (compound 25b) is a formyl peptide receptor 1 (FPR1) antagonist with an IC50 of 70 nM. FPR1 antagonist 2 inhibits cell growth through a combined effect on cell proliferation and apoptosis and reduces cell migration, while inducing an increase in angiogenesis.
  • HY-176403
    FPR1 antagonist 3
    		Antagonist
    FPR1 antagonist 3 (compound 10) is a potent and selective FPR1 antagonist. FPR1 antagonist 3 inhibits superoxide anion generation and elastase release with IC50s of 0.33 and 0.84 μM, respectively.
  • HY-P2355A
    BOC-FlFlF TFA
    		Antagonist
    BOC-FlFlF (TFA) (Boc-Phe-dLeu-Phe-dLeu-Phe (TFA)) is a selective FPR1 antagonist. BOC-FlFlF has an apparent dissociation constant (KD) of 230 nM as determined by the intracellular calcium mobilization assay. BOC-FlFlF can be used for the study of inflammation.