2. Signaling Pathways
  3. Others
  4. Drug Derivative

Drug Derivative

Drug derivative

Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.

Drug Derivative Related Products (1652):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-124124S
    N-Methylnicotinamide-d4
    		98.23%
    N-Methylnicotinamide-d4 is the deuterium labeled N-Methylnicotinamide (HY-124124). N-Methylnicotinamide is an endogenous metabolite with antithrombotic effect. N-Methylnicotinamide via production/release of prostacyclin inhibits arterial thrombosis development. N-Methylnicotinamide is also the N-methylation product from nicotinamide catalyzed by N-methyltransferase within nicotinate and nicotinamide metabolism pathway.
    N-Methylnicotinamide-d<sub>4</sub>
  • HY-W015179
    1,2-O-Isopropylidene-alpha-D-xylofuranose
    		99.93%
    1,2-O-Isopropylidene-alpha-D-xylofuranose is a derivative of D-xylose (HY-N0537). 1,2-O-isopropylidene-α-D-xylofuranose can be used in the asymmetric alkylation of Benzaldehyde with Diethylzinc.
    1,2-O-Isopropylidene-alpha-D-xylofuranose
  • HY-139409A
    2-Deoxy-D-glucose 6-phosphate disodium
    		≥98.0%
    2-Deoxy-D-glucose 6-phosphate disodium, a derivative of 2-Deoxy-D-glucose, is produced in mammalian cells by the action of hexokinase on 2-DG. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.
    2-Deoxy-D-glucose 6-phosphate disodium
  • HY-W506071
    3,7-Dimethyluric acid
    3,7-Dimethyluric acid is a methyl derivative of uric acid.
    3,7-Dimethyluric acid
  • HY-Z11724
    Semaglutide Main Chain (9-37)
    		99.62%
    Semaglutide Main Chain (9-37) is a peptide starting material in the synthesis of semaglutide (HY-114118).
    Semaglutide Main Chain (9-37)
  • HY-129048
    Fladrafinil
    		98.57%
    Fladrafinil (CRL-40,941) is a nootropic.
    Fladrafinil
  • HY-W088929
    H-Glu(OtBu)-NH2 hydrochloride
    		98.0%
    H-Glu(OtBu)-NH2 (hydrochloride) is an active compound.
    H-Glu(OtBu)-NH2 hydrochloride
  • HY-133513
    (±)-H3RESCA-TFP
    		98.15%
    (±)-H3RESCA-TFP ((±)-H3L28) is a tetrafluorophenyl ester derivative of restrained complexing agent (RESCA). (±)-H3RESCA-TFP can be used to conjugate the chelator with a biomolecule via amine coupling (e.g., N terminus and/or the ε-amino groups of lysine).
    (±)-H3RESCA-TFP
  • HY-B1044
    Idramantone
    		99.94%
    Idramantone (Kemantane, 5-Hydroxy-2-adamantanone) is an Adamantane derivative. Idramantone is an immunostimulant. Idramantone is a versatile starting material for the synthesis of various adamantine deivatives. Idramantone can be produced using P450cam monooxygenase coupled with NADH regeneration as an oxidation biocatalyst. Idramantone can be studied in research on bronchial pathology.
    Idramantone
  • HY-Y1777
    2-Phenylacetophenone
    		99.91%
    2-Phenylacetophenone has broad-spectrum efflux pump inhibition activity. 2-Phenylacetophenone is a benzoin derivative used as a photoinitiator in vinyl polymerization.
    2-Phenylacetophenone
  • HY-W004292
    1-Undecanol
    		99.79%
    1-Undecanol (Undecyl alcohol) is the main product generated from the degradation of 2-tridecanone by Pseudomonas bacteria isolated from the soil. 1-Undecanol can enhance the attraction of Grapholita molesta to sex pheromone traps.
    1-Undecanol
  • HY-146748
    Sorbicillin
    		99.69%
    Sorbicillin, a sorbicillinoid analogue, acts as a potent anti-inflammation agent.
    Sorbicillin
  • HY-139093A
    Paracetamol-cysteine TFA
    		99.0%
    Paracetamol-cysteine (TFA) is an acetaminophen-protein adduct formed during the metabolism of acetaminophen (HY-66005).
    Paracetamol-cysteine TFA
  • HY-131501
    Menaquinone 9
    		98.0%
    Menaquinone 9 is a vitamin K2 (HY-109569) analog. Menaquinone 9 acts as a prothrombogenic agent and functional electron transfer component in nitrate reductase.
    Menaquinone 9
  • HY-126247B
    (R)-BI-2852
    (R)-BI-2852 is the isomer of BI-2852 (HY-126247), and can be used as an experimental control. BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.
    (R)-BI-2852
  • HY-W588263
    Indole-3-acetyl glutamate
    		99.68%
    Indole-3-acetyl glutamate (IAGlu) is a derivative of the plant hormone indole-3-acetic acid (IAA). As a conjugated form of IAA, Indole-3-acetyl glutamate involves in the transport, storage, and homeostatic regulation of IAA within the plant. Indole-3-acetyl glutamate can be used for research into the effects of plant hormones on the growth and development of plants.
    Indole-3-acetyl glutamate
  • HY-W017100
    2-Hydroxy-6-methoxybenzoic acid
    		99.34%
    2-Hydroxy-6-methoxybenzoic acid (6-Methoxysalicylic acid) is an orally active derivative of Salicylic acid (HY-B0167). 2-Hydroxy-6-methoxybenzoic acid can be isolated from the plant Brickellia veronicifolia. 2-Hydroxy-6-methoxybenzoic acid has analgesic properties.
    2-Hydroxy-6-methoxybenzoic acid
  • HY-111178
    Lauflumide
    		99.89%
    Lauflumide (BisfluoroModafinil) is the common alternative of modafinil. Modafinil is commonly prescribed for the research narcolepsy. Lauflumide has the potential for cognitive enhancing.
    Lauflumide
  • HY-120784
    Hexafluoro-diallylhexaflurobisphenol
    Hexafluoro-diallylhexaflurobisphenol is a Honokiol analogue (HA). Honokiol is a bioactive, biphenolic phytochemical that possesses potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities by targeting a variety of signaling molecules.
    Hexafluoro-diallylhexaflurobisphenol
  • HY-W024485
    SARS-CoV-2-IN-86
    		99.35%
    SARS-CoV-2-IN-86 (Compound 2734589) is SARS-CoV-2 methyltransferases nsp14 and nsp16 inhibitor, Andrographolide (HY-N0191) derivative. SARS-CoV-2-IN-86 has low toxicity, and according to toxicity analysis, the predicted LD50 is 700 mg/kg.
    SARS-CoV-2-IN-86