2. Signaling Pathways
  3. Anti-infection
  4. Beta-lactamase

Beta-lactamase

β-lactamase

Beta-lactamase (β-lactamase) is associated with multiple drug resistance in bacteria. It is able to hydrolyze or degrade the β-lactam ring, which is the core structure and active region of many antibiotic molecules such as penicillin, cephalosporins and kanamycin. Bacteria produce Lactamase in response to beta-lactam antibiotics. Using Lactamase inhibitors inhibits the activity of Lactamase so that it cannot destroy the beta-lactam ring of the antibiotic. Lactamase inhibitors are often used with beta-lactam antibiotics to enhance their effectiveness.

Beta-lactamase Isoform Specific Products:

Beta-lactamase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B1418S2
    Tazobactam-15N,d2
    		Inhibitor
    Tazobactam-15N,d2 (CL-298741-15N,d2) is 15N and deuterium labeled Tazobactam. Tazobactam (CL-298741) is a potent β-lactamases inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research.
    Tazobactam-<sup>15</sup>N<sub>,d<sub>2</sub>
  • HY-B0368C
    epi-D-Captopril
    		Inhibitor
    epi-D-Captopril (epi-D-SQ 14225) is a stereoisomer of Captopril (HY-B0368) and an inhibitor of metallo-β-lactamases (MBLs). The IC50 values of epi-D-Captopril against NDM-1, IMP-1, and VIM-2 are 64 μM, 173 μM, and 5.5 μM, respectively. epi-D-Captopril is expected to be used in the research of diseases caused by MBLs-related drug-resistant bacterial infections.
    epi-D-Captopril
  • HY-113557
    DNAC-1
    		Activator
    DNAC-1 is a potent antibacterial agent. DNAC-1 enhances β-lactam activity against Gram positive and Gram negative pathogens.
    DNAC-1
  • HY-173472
    MBL-IN-5
    		Inhibitor
    MBL-IN-5 is a metallo-β-lactamase (MBL) inhibitor. MBL-IN-5 inhibits three clinically relevant B1 subfamily MBLs (NDM-1, VIM-1, and IMP-1) with IC50s of 0.05  nM, 14  nM and 21 nM respectively. MBL-IN-5 remarkably enhances carbapenems’ effectiveness against MBL-producing clinical strains and significantly reduces the bacterial load in a neutropenic murine thigh infection model combined with the IPM antibiotic.
    MBL-IN-5
  • HY-175495
    NDM-1-IN-9
    		Inhibitor
    NDM-1-IN-9 (compound M7) is an orally active NDM-1 inhibitor with a Ki value of 3.95 nM.
    NDM-1-IN-9
  • HY-175488
    RPX 7546
    		Inhibitor
    RPX 7546 is a potent inhibitor of metallo-𝛽-lactamases (MBLs) with IC50 values of 1.4 and 48 μM for IMP-1 and IMP-78, respectively. RPX 7546 has antibacterial activity.
    RPX 7546
  • HY-A0256BR
    Clavulanate lithium (Standard)
    		Inhibitor
    Clavulanate (lithium) (Standard) is the analytical standard of Clavulanate (lithium). This product is intended for research and analytical applications. Clavulanate lithium is a potent β-lactamase inhibitor and acts as an antibiotic.
    Clavulanate lithium (Standard)
  • HY-105751
    Kalafungin
    		Inhibitor
    Kalafungin is an antibiotic, antimicrobial agent and a β-lactamase inhibitor from marine Streptomyces, with IC50 of 225.37 μM. Kalafungin destroys cell membranes. Kalafungin shows inhibitory activities against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria (such as S. aureus ATCC 33591 and S. aureus ATCC 23591), and, to a lesser extent, gram-negative bacteria.
    Kalafungin
  • HY-13271R
    Tubastatin A Hydrochloride (Standard)
    		Inhibitor
    Tubastatin A (Hydrochloride) (Standard) is the analytical standard of Tubastatin A (Hydrochloride). This product is intended for research and analytical applications. Tubastatin A Hydrochloride (Tubastatin A HCl) is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A Hydrochloride also inhibits HDAC10 and metallo-β-lactamase domain-containing protein 2 (MBLAC2).
    Tubastatin A Hydrochloride (Standard)
  • HY-13271AR
    Tubastatin A (Standard)
    		Inhibitor
    Tubastatin A (Standard) is the analytical standard of Tubastatin A. This product is intended for research and analytical applications. Tubastatin A is a potent and selective HDAC6 inhibitor with an IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A also inhibits HDAC10 and metallo-β-lactamase domain-containing protein 2 (MBLAC2).
    Tubastatin A (Standard)
  • HY-W740028
    Cefditoren-d3 sodium
    		Inhibitor
    Cefditoren-d3 (sodium) (ME 1206-d3) is deuterium labeled Cefditoren (sodium). Cefditoren sodium (ME 1206) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren sodium has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren sodium can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.
    Cefditoren-d<sub>3</sub> sodium
  • HY-117951
    ANT431
    		Inhibitor
    ANT431 is a metallo-β-lactamase inhibitor that also restores the effectiveness of Meropenem (HY-13678) in a mouse thigh Escherichia coli infection model.
    ANT431
  • HY-163191
    NDM-1 inhibitor-5
    		Inhibitor
    NDM-1 inhibitor-5 (compound 57) is a potent NDM-1 inhibitor, with a Ki of 2.5 μM. NDM-1 inhibitor-5 also shows antibacterial synergistic activity with meropenem (HY-13678).
    NDM-1 inhibitor-5
  • HY-N13980
    Carpetimycin D
    		Inhibitor
    Carpetimycin D has very strong activity against Gram-positive and negative bacteria (including β-lactamase producing bacteria). Carpetimycin D has a strong inhibitory effect on β-lactamase.
    Carpetimycin D
  • HY-13322R
    Pracinostat (Standard)
    		Inhibitor
    Pracinostat (Standard) is the analytical standard of Pracinostat. This product is intended for research and analytical applications. Pracinostat is a potent histone deacetylase (HDAC) inhibitor, with IC50s of 40-140 nM, used for cancer research. Pracinostat also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) hydrolase activity with an EC50 below 10 nM.
    Pracinostat (Standard)
  • HY-14879R
    Avibactam free acid (Standard)
    		Inhibitor
    Avibactam (free acid) (Standard) is the analytical standard of Avibactam (free acid). This product is intended for research and analytical applications. Avibactam (NXL-104) free acid is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively[1].
    Avibactam free acid (Standard)
  • HY-N15020
    Izumenolide
    		Inhibitor
    Izumenolide is found in the strain of Micromonospora chalcea subsp. izumensis. Izumenolide inhibited some β-lactamases, and the IC50 concentration of TEM-2 β-lactamase was 0.01 μg/mL.
    Izumenolide
  • HY-168861
    NDM-1 inhibitor-8
    		Inhibitor
    NDM-1 inhibitor-8 (Compound 18b) is the covalent inhibitor for new delhi metallo-β-lactamase-1 (NDM-1) with an IC50 of 7.03 μM. NDM-1 inhibitor-8 inhibits the drug resistant strains, exhibits synergistic antibacterial effect with the use of Meropenem (HY-13678). NDM-1 inhibitor-8 exhibits anti-infectious activity in mouse models.
    NDM-1 inhibitor-8
  • HY-N13978
    Carpetimycin B
    		Inhibitor
    Carpetimycin B has very strong activity against Gram-positive and negative bacteria (including β-lactamase producing bacteria). Carpetimycin B has a strong inhibitory effect on β-lactamase.
    Carpetimycin B
  • HY-17452AR
    Cefditoren Pivoxil (Standard)
    		Inhibitor
    Cefditoren Pivoxil (Standard) is the analytical standard of Cefditoren Pivoxil. This product is intended for research and analytical applications. Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.
    Cefditoren Pivoxil (Standard)
Beta-lactamase Isoform Comparison

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