2. Signaling Pathways
  3. GPCR/G Protein
  4. Arrestin
  5. Arrestin-2/β-Arrestin 1 Isoform
  6. Arrestin-2/β-Arrestin 1 Agonist

Arrestin-2/β-Arrestin 1 Agonist

Arrestin-2/β-Arrestin 1 Agonist (1):

Cat. No. Product Name Effect Purity
  • HY-P2141
    TRV-120027
    		Agonist 98.11%
    TRV120027, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages β-arrestins while blocking G-protein signaling. TRV120027 induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R-β-arrestin-1-TRPC3-PLCγ at the plasma membrane. TRV120027 inhibits angiotensin II-mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for the acute decompensated heart failure (ADHF) treatment.