2. Signaling Pathways
  3. GPCR/G Protein
  4. Adhesion G Protein-coupled Receptors (AGPCRs)
  5. Adhesion G Protein-coupled Receptors (AGPCRs) Agonist

Adhesion G Protein-coupled Receptors (AGPCRs) Agonist

Adhesion G Protein-coupled Receptors (AGPCRs) Agonists (2):

Cat. No. Product Name Effect Purity
  • HY-P10365
    VPM-p15
    		Agonist 98.18%
    Vmm-p15 is a peptide agonist optimized for the adhesion G protein-coupled receptor GPR64 (also known as ADGRG2 or HE6). The affinity of VPM-p15 with GPR64 is significantly higher than that of the original p15 peptide. The cAMP level induced by VMM-P15 increased significantly, activated GPR64, and triggered downstream Gs, Gq, and G12/13 signaling. VPM-p15 can be used to study the activation mechanism of adherent GPCR family members.
  • HY-107216A
    (3aS,4R,9bR)-G-1
    		Agonist
    (3aS,4R,9bR)-G-1 is a highly selective G protein-coupled receptor GPR30 (GPER) agonist with a Ki value of approximately 7 nM. (3aS,4R,9bR)-G-1 activates rapid signaling pathways such as intracellular calcium mobilization and PI3K signaling through GPR30, promoting uterine epithelial cell proliferation and exerting antidepressant effects. (3aS,4R,9bR)-G-1 is promising for research of breast cancer and depression.