Wee1

Related Products

Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe). Wee1 has amolecular mass of 96 kDa and it is a key regulator of cell cycle progression. Wee1 influences cell size by inhibiting the entry into mitosis, through inhibiting Cdk1. Wee1 has homologues in many other organisms, including mammals. Wee1 inhibits Cdk1 by phosphorylating it on two different sites, Tyr15 and Thr14. Cdk1 is crucial for the cyclin-dependent passage of the various cell cycle checkpoints. At least three checkpoints exist for which the inhibition of Cdk1 by Wee1 is important: G₂/M checkpoint, Cell size checkpoint, DNA damage checkpoint. Wee1 is shown to phosphorylate histone H2B at tyrosine 37 residue which regulates global expression of histones.
WEE1 subfamily includes PMYT1.

Wee1 Related Products (45):

By Effects:	Inhibitors (36) Degraders (3)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-162987

PKMYT1-IN-6	Inhibitor
PKMYT1-IN-6 (compund 98) is a PKMYT1 inhibitor with IC₅₀ less than 50 nM.

HY-10993R

Adavosertib (Standard)	Inhibitor
Adavosertib (Standard) is the analytical standard of Adavosertib. This product is intended for research and analytical applications. Adavosertib (AZD-1775; MK-1775) is a potent Wee1 inhibitor with an IC₅₀ of 5.2 nM.

HY-162986

PKMYT1-IN-4	Inhibitor
PKMYT1-IN-4 (compund 27) is a PKMYT1 inhibitor with IC₅₀ less than 50 nM.

HY-159937

PKMYT1-IN-7	Inhibitor
PKMYT1-IN-7 (compound 7) is an orally active PKMYT1 inhibitor with IC₅₀ values of 1.6 nM and 0.06 μM against of PKMYT1 and pCDK1, respectively. PKMYT1-IN-7 suppresses the phosphorylation of CDK1 at T14 and Y15. PKMYT1-IN-7 shows anticancer activity both < and <.

HY-162988

Myt1-IN-5	Inhibitor
Myt1-IN-5 (compound 4) is a membrane-associated tyrosine and threonine-specific cdc2-inhibitory kinase (Myt1) (Gene name PKMYT1) inhibitor with an IC₅₀ of less than 200 nM.

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