2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Tyrosinase

Tyrosinase

Tyrosinase

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Tyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins and catechol oxidases. Tyrosinases are the catalysts in mammals responsible for the formation of melanin in skin and hair color, as well as browning in fruit and vegetables following cell damage.

Tyrosinases are found in various prokaryotes as well as in plants, fungi, arthropods, and mammals and are responsible for pigmentation, wound healing, radiation protection, and primary immune response. Tyrosinases perform two sequential enzymatic reactions: hydroxylation of monophenols and oxidation of diphenols to form quinones which polymerize spontaneously to melanin. In plants, sponges, and many invertebrates, tyrosinases are important for wound healing and primary immune responses; in arthropods, they play a role in sclerotization, and in bacteria, tyrosinases protect DNA from UV damage.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N10016
    Chlorogenic acid butyl ester
    		Inhibitor
    Chlorogenic acid butyl ester, a caffeoylquinic acid, is a potent melanogenesis inhibitor. Chlorogenic acid butyl ester inhibits the expression of microphtalmia-associated transcription factor (MITF), tyrosinase, tyrosinerelated protein 1 (TRP-1), and TRP-2. Chlorogenic acid butyl ester also shows antioxidant activity.
    Chlorogenic acid butyl ester
  • HY-159917
    PPL agonist-1
    		Activator
    PPL agonist-1 is a highly selective Periplakin (PPL) agonist that increases cAMP levels by regulating PPL, thereby enhancing MITF expression and promoting melanin synthesis. Furthermore, PPL agonist-1 facilitates melanin production by regulating tryptophan metabolism. Compared to Ruxolitinib (HY-50856), PPL agonist-1 demonstrates superior efficacy. PPL agonist-1 holds potential for research into vitiligo treatment.
    PPL agonist-1
  • HY-N10437
    6-Acetylnimbandiol
    		Inhibitor
    6-Acetylnimbandiol (6-O-Acetylnimbandiol) is a non-cytotoxic tyrosinase inhibitor (IC50=69.85 μM) that effectively inhibits melanin production and MITF expression. 6-Acetylnimbandiol can be used in melanoma research.
    6-Acetylnimbandiol
  • HY-N0646R
    Silydianin (Standard)
    		Inhibitor
    Silydianin (Standard) is the analytical standard of Silydianin (HY-N0646). This product is intended for research and analytical applications. Silydianin is a flavonolignan. Silydianin can be obtained from Silybum marianum. Silydianin inhibits PTP1B with an IC50 of 17.38 μM. Silydianin inhibits both monophenolase and diphenolase of tyrosinase significantly, with IC50s of 2.6 μM and 16.5 μM, respectively. Silydianin induces Apoptosis and reduces cytokines (IL-4 and IL-5). Silymarin has antioxidant, cytoprotective and immunomodulatory effects. Silydianin has antitumor activity against prostate cancer. Silymarin can be used in allergic asthma research.
    Silydianin (Standard)
  • HY-N1658
    2,3-Dihydroisoginkgetin
    		Inhibitor
    2,3-Dihydroisoginkgetin, a biflavonoid, is a inhibitor of Tyrosinase, with 36.84% inhibition at 0.1 mM. 2,3-Dihydroisoginkgetin shows less toxicity in HEMn (human epidermal melanocytes) cells, with an IC50 of 86.16 μM.
    2,3-Dihydroisoginkgetin
  • HY-P990471
    Anti-MSPR/RON/CD136 Antibody
    The Anti-MSPR/RON/CD136 Antibody is a human antibody expressed in CHO, targeting MSPR/RON/CD136. The Anti-MSPR/RON/CD136 Antibody is equipped with huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145.74 kDa. The isotype control for the Anti-MSPR/RON/CD136 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-MSPR/RON/CD136 Antibody
  • HY-N1780R
    3,4-Dimethoxyphenol (Standard)
    		Inhibitor
    Lithocholic acid (Standard) is the analytical standard of Lithocholic acid. This product is intended for research and analytical applications. Lithocholic acid is a toxic secondary bile acid that can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is also a FXR antagonist and a PXR/SXR agonist.
    3,4-Dimethoxyphenol (Standard)
  • HY-N3654
    Cyclo(l-Pro-d-Leu)
    		Inhibitor
    Cyclo(l-Pro-d-Leu) (compound 11) is a collagenase inhibitor that can be extracted from R. atalantica and also exhibits a mild tyrosinase inhibitory effect.
    Cyclo(l-Pro-d-Leu)
  • HY-143451
    Tyrosinase-IN-4
    		Inhibitor
    Tyrosinase-IN-4 (compound 34) is a potent inhibitor of tyrosinase. Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-4 has the potential for the research of skin whitening agents and food preservatives.
    Tyrosinase-IN-4
  • HY-161950
    Tyrosinase-IN-33
    		Inhibitor
    Tyrosinase-IN-33 (compound 5) a Pyridine-based compound, is a potent inhibitor of mushroom tyrosinase diphenolase activity. Tyrosinase-IN-33 significantly decreases the enzyme activity, with an IC50 of 9.0 μM.
    Tyrosinase-IN-33
  • HY-N0136S
    Taxifolin-d3
    		Inhibitor
    Taxifolin-d3 is deuterium labeled Taxifolin. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity.
    Taxifolin-d<sub>3</sub>
  • HY-W013636AG
    2-Ketoglutaric acid Sodium (GMP)
    		Inhibitor
    2-Ketoglutaric acid (Alpha-Ketoglutaric acid) Sodium (GMP) is 2-Ketoglutaric acid Sodium (HY-W013636A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. 2-Ketoglutaric acid Sodium is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC50=15 mM).
    2-Ketoglutaric acid Sodium (GMP)
  • HY-145111
    TNK2-IN-1
    		Inhibitor
    TNK2-IN-1 is a TNK2 inhibitor. TNK2-IN-1 has an IC50 of 224 nM for TNK2. TNK2-IN-1 can be used for the research of cancer.
    TNK2-IN-1
  • HY-168436
    Tyrosinase-IN-40
    		Inhibitor
    Tyrosinase-IN-40 (Compound 9r) is a competitive-type tyrosinase inhibitor, with an IC50 value of 17.02  µM, a Ki value of 14.87 µM. Tyrosinase-IN-40 displays antioxidant activity. Tyrosinase-IN-40 can be used in melanin-related studies.
    Tyrosinase-IN-40
  • HY-N7929R
    5-Feruloylquinic acid (Standard)
    		Inhibitor
    5-Feruloylquinic acid (Standard) is the analytical standard of 5-Feruloylquinic acid. This product is intended for research and analytical applications. 5-Feruloylquinic acid (5-FQA) possesses antioxidative effects and tyrosinase inhibitory activities.
    5-Feruloylquinic acid (Standard)
  • HY-163326
    Tyrosinase-IN-25
    		Inhibitor
    Tyrosinase-IN-25 (compound 1l) is an inhibitor of tyrosinase and melanin biosynthesis in human melanoma cells.
    Tyrosinase-IN-25
  • HY-151979
    Tyrosinase-IN-8
    		Inhibitor
    Tyrosinase-IN-8 is a potent tyrosinase inhibitor with an IC50 value of 1.6 µM. Tyrosinase-IN-8 inhibits cell growth with low cytotoxicity.
    Tyrosinase-IN-8
  • HY-121374
    Cardanol diene
    		Inhibitor
    Cardanol diene is a phenol found in cashew nut shell liquid that inhibits tyrosinase with an IC50 value of 52.5 μM in vitro.1 Cardanol diene is also used to synthesize cardanol-metal complexes that inhibit uropathogenic E. coli biofilm formation.
    Cardanol diene
  • HY-N2962
    Broussonin C
    		Inhibitor
    Broussonin C is a competitive inhibitor of Tyrosinase that can be isolated from Broussonetia kazinoki. Broussonin C inhibits monophenolase and diphenolase with IC50s of 0.43 and 0.57 μM, respectively.
    Broussonin C
  • HY-155247
    Tyrosinase-IN-14
    		Inducer
    Tyrosinase-IN-14 (compound 7m) is a tyrosinase inhibitor that reduces the catalytic activity of tyrosinase by changing its secondary structure. Tyrosinase-IN-14 has low cytotoxicity and anti-browning activity in fruits. Tyrosinase-IN-14 effectively inhibits banana browning during storage.
    Tyrosinase-IN-14
Cat. No. Product Name / Synonyms Application Reactivity