2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Tyrosinase

Tyrosinase

Tyrosinase

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Tyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins and catechol oxidases. Tyrosinases are the catalysts in mammals responsible for the formation of melanin in skin and hair color, as well as browning in fruit and vegetables following cell damage.

Tyrosinases are found in various prokaryotes as well as in plants, fungi, arthropods, and mammals and are responsible for pigmentation, wound healing, radiation protection, and primary immune response. Tyrosinases perform two sequential enzymatic reactions: hydroxylation of monophenols and oxidation of diphenols to form quinones which polymerize spontaneously to melanin. In plants, sponges, and many invertebrates, tyrosinases are important for wound healing and primary immune responses; in arthropods, they play a role in sclerotization, and in bacteria, tyrosinases protect DNA from UV damage.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-161950
    Tyrosinase-IN-33
    		Inhibitor
    Tyrosinase-IN-33 (compound 5) a Pyridine-based compound, is a potent inhibitor of mushroom tyrosinase diphenolase activity. Tyrosinase-IN-33 significantly decreases the enzyme activity, with an IC50 of 9.0 μM.
    Tyrosinase-IN-33
  • HY-N0136S
    Taxifolin-d3
    		Inhibitor
    Taxifolin-d3 is deuterium labeled Taxifolin. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].
    Taxifolin-d<sub>3</sub>
  • HY-145111
    TNK2-IN-1
    		Inhibitor
    TNK2-IN-1 is a TNK2 inhibitor. TNK2-IN-1 has an IC50 of 224 nM for TNK2. TNK2-IN-1 can be used for the research of cancer.
    TNK2-IN-1
  • HY-168436
    Tyrosinase-IN-40
    		Inhibitor
    Tyrosinase-IN-40 (Compound 9r) is a competitive-type tyrosinase inhibitor, with an IC50 value of 17.02  µM, a Ki value of 14.87 µM. Tyrosinase-IN-40 displays antioxidant activity. Tyrosinase-IN-40 can be used in melanin-related studies.
    Tyrosinase-IN-40
  • HY-N0192S
    Arbutin-d4
    		Inhibitor
    Arbutin-d4 is deuterium labeled Arbutin. Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents[1]. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties[2][3].
    Arbutin-d<sub>4</sub>
  • HY-N7929R
    5-Feruloylquinic acid (Standard)
    		Inhibitor
    5-Feruloylquinic acid (Standard) is the analytical standard of 5-Feruloylquinic acid. This product is intended for research and analytical applications. 5-Feruloylquinic acid (5-FQA) possesses antioxidative effects and tyrosinase inhibitory activities.
    5-Feruloylquinic acid (Standard)
  • HY-163326
    Tyrosinase-IN-25
    		Inhibitor
    Tyrosinase-IN-25 (compound 1l) is an inhibitor of tyrosinase and melanin biosynthesis in human melanoma cells.
    Tyrosinase-IN-25
  • HY-151979
    Tyrosinase-IN-8
    		Inhibitor
    Tyrosinase-IN-8 is a potent tyrosinase inhibitor with an IC50 value of 1.6 µM. Tyrosinase-IN-8 inhibits cell growth with low cytotoxicity.
    Tyrosinase-IN-8
  • HY-121374
    Cardanol diene
    		Inhibitor
    Cardanol diene is a phenol found in cashew nut shell liquid that inhibits tyrosinase with an IC50 value of 52.5 μM in vitro.1 Cardanol diene is also used to synthesize cardanol-metal complexes that inhibit uropathogenic E. coli biofilm formation.
    Cardanol diene
  • HY-N2962
    Broussonin C
    		Inhibitor
    Broussonin C is a competitive inhibitor of Tyrosinase that can be isolated from Broussonetia kazinoki. Broussonin C inhibits monophenolase and diphenolase with IC50s of 0.43 and 0.57 μM, respectively.
    Broussonin C
  • HY-155247
    Tyrosinase-IN-14
    		Inducer
    Tyrosinase-IN-14 (compound 7m) is a tyrosinase inhibitor that reduces the catalytic activity of tyrosinase by changing its secondary structure. Tyrosinase-IN-14 has low cytotoxicity and anti-browning activity in fruits. Tyrosinase-IN-14 effectively inhibits banana browning during storage.
    Tyrosinase-IN-14
  • HY-158235
    Tyrosinase-IN-27
    		Inhibitor
    Tyrosinase-IN-27 (compound 6f) is a tyrosinase (TYR) inhibitor (IC50: 0.88 μM) that statically quenches TYR. Tyrosinase-IN-27 increases the hydrophobicity of the enzyme microenvironment by binding to TYR, reducing the content of α-helices in the enzyme and changing its secondary structure. Tyrosinase-IN-27 can be used in the food industry to effectively inhibit the browning of lotus root slices..
    Tyrosinase-IN-27
  • HY-N5118
    Chimonanthine
    		Inhibitor
    Chimonanthine is an alkaloid of Chimonanthus praecox, inhibits tyrosinase and tyrosine-related protein-1 mRNA expression, amd inhibits melanogenesis.
    Chimonanthine
  • HY-Y0444S
    D-Tyrosine-d2
    		Inhibitor
    D-Tyrosine-d2 is the deuterium labeled D-Tyrosine (HY-Y0444). D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth.
    D-Tyrosine-d<sub>2</sub>
  • HY-139857
    Piceid 6″-O-azelaic acid ester
    		Inhibitor
    Piceid 6″-O-azelaic acid ester shows high intracellular tyrosinase inhibitory and depigmentating activities.
    Piceid 6″-O-azelaic acid ester
  • HY-N12810
    Sanggenon O
    		Inhibitor
    Sanggenon O is a mushroom tyrosinase inhibitor that can be isolated from Morus nigra, with an IC50 value of 1.15 μM.
    Sanggenon O
  • HY-N11521
    7-Methoxy obtusifolin
    		Inhibitor
    7-Methoxy obtusifolin (Compound 4) is a competitive tyrosinase inhibitor with an IC50 of 7.0 μM.
    7-Methoxy obtusifolin
  • HY-162909
    Tyrosinase-IN-38
    		Inhibitor
    Tyrosinase-IN-38 (compound 6b) is a competitive Tyrosinase inhibitor with IC50 value of 25.82 μM. Tyrosinase-IN-38 has antioxidant activity.
    Tyrosinase-IN-38
  • HY-143449
    Tyrosinase-IN-2
    		Inhibitor 99.71%
    Tyrosinase-IN-2 (compound 67) is a potent inhibitor of tyrosinase. Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-2 has the potential for the research of skin whitening agents and food preservatives.
    Tyrosinase-IN-2
  • HY-152194
    Tyrosinase-IN-10
    		Inhibitor
    Tyrosinase-IN-10 (Compound 23) is a partially competitive tyrosinase inhibitor with an IC50 of 1.6 μM against tyrosinase activity from human melanoma cell lysates.
    Tyrosinase-IN-10
Cat. No. Product Name / Synonyms Application Reactivity