Tyrosinase

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Tyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins and catechol oxidases. Tyrosinases are the catalysts in mammals responsible for the formation of melanin in skin and hair color, as well as browning in fruit and vegetables following cell damage.

Tyrosinases are found in various prokaryotes as well as in plants, fungi, arthropods, and mammals and are responsible for pigmentation, wound healing, radiation protection, and primary immune response. Tyrosinases perform two sequential enzymatic reactions: hydroxylation of monophenols and oxidation of diphenols to form quinones which polymerize spontaneously to melanin. In plants, sponges, and many invertebrates, tyrosinases are important for wound healing and primary immune responses; in arthropods, they play a role in sclerotization, and in bacteria, tyrosinases protect DNA from UV damage.

Tyrosinase Related Products (243)
Antibodies (9)

By Effects:	Substrates (3) Inhibitors (211) Degrader (1) Antagonist (1) Activators (8) Modulator (1) Inducer (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N7929

5-Feruloylquinic acid	Inhibitor	99.73%
5-Feruloylquinic acid (5-FQA) possesses antioxidative effects and tyrosinase inhibitory activities.

HY-P99622

Flanvotumab	Inhibitor	≥99.0%
Flanvotumab (IMC-20D7S) is a human monoclonal antibody targeting to tyrosinase-related protein (TYRP1), specifically expressed in melanocytes and melanoma cells. Flanvotumab acts function via natural killing-mediated antibody-dependent cell-mediated cytotoxicity (ADCC). Flanvotumab has potent anti-tumor activity and good tolerance.

HY-W013636S2

2-Ketoglutaric acid-d₆		98.62%
2-Ketoglutaric acid-d₆ (Alpha-Ketoglutaric acid-d₆) is the deuterium labeled 2-Ketoglutaric acid (HY-W013636). 2-Ketoglutaric acid is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC₅₀=15 mM).

HY-N1386

2-Methoxycinnamic acid	Inhibitor	99.75%
2-Methoxycinnamic acid is a noncompetitive inhibitor of tyrosinase.

HY-W013636B

Calcium 2-oxoglutarate	Inhibitor	≥98.0%
Calcium 2-oxoglutarate is an intermediate in the production of ATP or GTP in the Krebs cycle. Calcium 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Calcium 2-oxoglutarate is a reversible inhibitor of tyrosinase (IC₅₀=15 mM).

HY-P3662

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2	Activator	99.50%
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanotropin, a melanocyte-stimulating hormone. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 stimulates tyrosinase and exhibits thermoregulatory effect in rats model.

HY-101243

XMD16-5	Inhibitor	98.20%
XMD16-5 is a potent TNK2 inhibitor with IC₅₀ values of 16 and 77 nM for the D163E and R806Q mutations, respectively.

HY-W015616

Benzylacetone	Inhibitor	99.78%
Benzylacetone is an aromatic compound from agarwood. Benzylacetone exhibits potent and reversible antityrosinase (mushroom) activity， with IC₅₀s of 2.8 mM and 0.6 mM for monophenolase and diphenolase, respectively. Benzylacetone has appetite-enhancing and locomotor-reducing effects.

HY-N2204

Swertiajaponin	Inhibitor	99.84%
Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC₅₀ of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity.

HY-I0400R

N-Acetylneuraminic acid (Standard)	Inhibitor
N-Acetylneuraminic acid (Standard) is the analytical standard of N-Acetylneuraminic acid. This product is intended for research and analytical applications. N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia.

HY-D0168

Orcinol	Inhibitor	99.97%
Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of MITF, tyrosinase (TYR), TRP1, and DCT. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases.

HY-P3452

Tetrapeptide-30	Inhibitor	99.59%
Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 can act as a tyrosinase inhibitor, lightening hyperpigmentation and evening out skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation.

HY-B1461

Deoxyarbutin	Inhibitor	99.92%
Deoxyarbutin is an orally active tyrosinase inhibitor that can promote apoptosis of melanoma cells, enhance the vitality of mouse acinar cells, and has skin whitening and anti-tumor activity^[1][2][3].

HY-N3517

Oxyresveratrol 3'-O-β-D-glucopyranoside	Inhibitor
Oxyresveratrol 3'-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective tyrosinase inhibitor with an IC₅₀ of 1.64 μM.

HY-N1750

3-(2,4-Dihydroxyphenyl)propanoic acid	Inhibitor	99.46%
3-(2,4-Dihydroxyphenyl)propanoic acid (DPPacid) is a potent and competitive tyrosinase inhibitor, inhibits L-Tyrosine and DL-DOPA with an IC₅₀ and a K_i of 3.02 μM and 11.5 μM, respectively.

HY-113068

(rel)-β-Tocopherol	Inhibitor	98.91%
(rel)-β-Tocopherol is a relative configuration of β-Tocopherol.(±)-β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol.

HY-N2101

Benzoyloxypaeoniflorin	Inhibitor	98.65%
Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a tyrosinase inhibitor against mushroom tyrosinase with IC₅₀ of 0.453 mM. Benzoyloxypaeoniflorin is NF-κB Inhibitor and contributes to improving blood circulation through its inhibitory effect on both platelet aggregation and blood coagulation.

HY-N0136A

(±)-Taxifolin	Inhibitor	99.34%
(±)-Taxifolin ((±)-Dihydroquercetin) is the racemate of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC₅₀ value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity.

HY-W037976

Tyrosinase-IN-22	Antagonist	99.75%
Tyrosinase-IN-22 (compound 4) is an inhibitor of tyrosinase substrates (L-tyrosine and L-dopa) with IC₅₀s of 60 nM and 30 nM, respectively. Tyrosinase-IN-22 also shows potent antioxidant and anti-melanogenic properties, thus can be used for relevant researches.

HY-N8223

Viscumneoside III	Inhibitor	98.74%
Viscumneoside III, a dihydroflavone O-glycoside, is a potent tyrosinase inhibitor with an IC₅₀ of 0.5 mM. Viscumneoside III has anti-angina pectoris.

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Tyrosinase

Tyrosinase

Tyrosinase Related Products (243)

Antibodies (9)

Tyrosinase Related Products (243):