2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Tyrosinase

Tyrosinase

Tyrosinase

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Tyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins and catechol oxidases. Tyrosinases are the catalysts in mammals responsible for the formation of melanin in skin and hair color, as well as browning in fruit and vegetables following cell damage.

Tyrosinases are found in various prokaryotes as well as in plants, fungi, arthropods, and mammals and are responsible for pigmentation, wound healing, radiation protection, and primary immune response. Tyrosinases perform two sequential enzymatic reactions: hydroxylation of monophenols and oxidation of diphenols to form quinones which polymerize spontaneously to melanin. In plants, sponges, and many invertebrates, tyrosinases are important for wound healing and primary immune responses; in arthropods, they play a role in sclerotization, and in bacteria, tyrosinases protect DNA from UV damage.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N10286
    Chetoseminudin B
    		Inhibitor
    Chetoseminudin B possesses mushroom tyrosinase inhibitory activity with IC50 of 31.7 μM.
    Chetoseminudin B
  • HY-126618
    Aspochalasin I
    		Inhibitor
    Aspochalasin I exhibits cytotoxicity against cancer cells NCIH460, MCF-7 and SF-268, with IC50s of 22.1, 33.4 and 19.9 μM. Aspochalasin I inhibits melanogenesis (IC50 of 22.4 μM) through inhibition of tyrosinase, and can thus be used as whitening agent.
    Aspochalasin I
  • HY-P5252
    Diaminopropionoyl tripeptide-33
    		Inhibitor
    Diaminopropionoyl tripeptide-33isa bioactive peptide with protects skin cells from UVA-induced DNA damages and has been reported used as a cosmetic ingredient.
    Diaminopropionoyl tripeptide-33
  • HY-120036
    Tyrphostin AG1112
    		Inhibitor
    Tyrphostin AG1112 is a potent inhibitors of CK II. Tyrphostin AG1112 inhibits p210bcr-abl tyrosine kinase, with IC50 values of 2, 15, 20 μM in p210bcr-abl, EGFR and PDGFR cells, respectively.
    Tyrphostin AG1112
  • HY-W013636AR
    2-Ketoglutaric acid Sodium (Standard)
    		Inhibitor
    2-Ketoglutaric acid (Sodium) (Standard) is the analytical standard of 2-Ketoglutaric acid (Sodium). This product is intended for research and analytical applications. 2-Ketoglutaric acid Sodium (Alpha-Ketoglutaric acid Sodium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC50=15 mM)[1][2].
    2-Ketoglutaric acid Sodium (Standard)
  • HY-147709
    Tyrosinase-IN-6
    Compound 4B proved to be the most effective tyrosinase inhibitor (ic50= 3.80 μ M) It also showed good antioxidant activity.
    Tyrosinase-IN-6
  • HY-155240
    Tyrosinase-IN-13
    		Inhibitor
    Tyrosinase-IN-13 (compound 3c), a derivative of Flurbiprofen (HY-10582), is a potent, non-competitive tyrosinase inhibitor (IC50=68 μM; Ki=36.3 μM). Tyrosinase-IN-13 is cytotoxic against hepatocellular carcinoma (HepG2), colorectal cancer (HT-29), and melanoma (B16F10).
    Tyrosinase-IN-13
  • HY-N3773
    Dodoviscin A
    		Inhibitor
    Dodoviscin A is a pigmentation-altering agent, which can be isolated from the aerial parts of Dodonaea viscosa. Dodoviscin A inhibits melanin production in B16-F10 melanoma cells. Dodoviscin A suppresses mushroom tyrosinase activity, and tyrosinase activity induced by 3-isobutyl-1-methylxanthine. Dodoviscin A also inhibits the phorphosylation of cAMP response element binding protein, induced by 3-isobutyl-1-methylxanthine and forskolin.
    Dodoviscin A
  • HY-116750
    6-Hydroxykaempferol
    		Inhibitor
    6-Hydroxykaempferol, a flavonoid, is a competitive tyrosinase inhibitor with an IC50 value of 124 μM. 6-Hydroxykaempferol has a Ki value of 148 μM relative to L-DOPA as a substrate and effectively inhibits the activity of the enzyme by binding to the active site of the enzyme.
    6-Hydroxykaempferol
  • HY-162894
    Tyrosinase-IN-37
    		Inhibitor
    Tyrosinase-IN-37 (Compound 3c) is an effective Tyrosinase inhibitor with an IC50 of 1.02 μM, exhibiting 14 times the inhibitory effect of kojic acid (Kojic acid, HY-W050154), which has an IC50 of 14.74 μM. Tyrosinase-IN-37 can effectively prevent the browning of Rosa roxburghii. Additionally, Tyrosinase-IN-37 can also inhibit browning that is not caused by Tyrosinase.
    Tyrosinase-IN-37
  • HY-Y0444S2
    D-Tyrosine-d7
    		Inhibitor
    D-Tyrosine-d7 is the deuterium labeled D-Tyrosine (HY-Y0444). D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth.
    D-Tyrosine-d<sub>7</sub>
  • HY-131327
    Azo-resveratrol
    		Inhibitor
    Azo-resveratrol, an Azo compound, inhibits Mushroom tyrosinase (IC50=36.28 μM).
    Azo-resveratrol
  • HY-169328
    Tyrosinase-IN-39
    		Inhibitor
    Tyrosinase-IN-39 (compound 5r) is a competitive tyrosinase inhibitor with the IC50 of 6.4 μM and can be used for study of skin diseases.
    Tyrosinase-IN-39
  • HY-168302
    BTK ligand 10
    		Degrader
    BTK ligand 10 is the ligand of BTK. BTK ligand 10 can be used to synthesize (R)-NX-2127 (HY-153220A).
    BTK ligand 10
  • HY-161241
    Tyrosinase-IN-23
    		Inhibitor
    Tyrosinase-IN-23 (Compd 11m) is a tyrosinase inhibitor with an IC50 of 55.39±4.93 µM. Tyrosinase-IN-23 can be used for research of melanin biosynthesis.
    Tyrosinase-IN-23
  • HY-N1750R
    3-(2,4-Dihydroxyphenyl)propanoic acid (Standard)
    		Inhibitor
    Garenoxacin (Standard) is the analytical standard of Garenoxacin. This product is intended for research and analytical applications. Garenoxacin (BMS284756) is an orally active quinolone antibiotic and has a broad spectrum of activity against a wide array of gram-positive and gram-negative bacteria, anaerobes, and fastidious organisms.
    3-(2,4-Dihydroxyphenyl)propanoic acid (Standard)
  • HY-W099579R
    Kojic acid dipalmitate (Standard)
    		Inhibitor
    Kojic acid dipalmitate (Standard) is the analytical standard of Kojic acid dipalmitate. This product is intended for research and analytical applications. Kojic acid dipalmitate (Kojic dipalmitate) is a derivative of Kojic acid (HY-W050154), a fungal metabolite that can be produced by species of Aspergillus, Acetobacter and Penicillium. Kojic acid dipalmitate is a slow and reversible competitive inhibitor of tyrosinase. Kojic acid dipalmitate can be used for skin‐lightening agent research.
    Kojic acid dipalmitate (Standard)
  • HY-135743
    Apovincamine
    		Inhibitor
    Apovincamine (cis-Apovincamine) is an indole alkaloid isolated from the Malaysian Alstonia pneumatophora (Apocynaceae). Apovincamine shows anti-melanogenesis activity.
    Apovincamine
  • HY-124827
    Tec-IN-1
    		Inhibitor
    Tec-IN-1 (Compound 21) is a Tec inhibitor (IC50s of 11.7 μM). Tec-IN-1 inhibits Tec-mediated tyrosine phosphorylation of FGF2, and inhibits FGF2 secretion from cells.
    Tec-IN-1
  • HY-161969
    Tyrosinase-IN-34
    		Inhibitor
    Tyrosinase-IN-34 (compound 5a) is a human tyrosinase inhibitor (IC50: 3.5 μM) with the potential to control melanogenesis and pigmentation.
    Tyrosinase-IN-34
Cat. No. Product Name / Synonyms Application Reactivity