TRPV

TRPV Related Products (45):

By Type:	Pan (14) Selective (18)
By Effects:	Ligand (1) Inhibitors (7) Agonists (13) Antagonists (21) Activators (3)

Cat. No.	Product Name	Effect	Purity

HY-118785

MSP-3	Agonist	98.53%
MSP-3 is a potent TRPV1 agonist, with an EC₅₀ of 0.87 μM. MSP-3 exhibits neuroprotective and antinociceptive effects.

HY-120294

Chrysin 6-C-glucoside 8-C-arabinoside	Inhibitor	99.11%
Chrysin 6-C-glucoside 8-C-arabinoside can inhibit the CGRP releasing and the activation of TRPV1 channel. Chrysin 6-C-glucoside 8-C-arabinoside can be used for anti-migraine research.

HY-W014394

Vanillyl butyl ether	Agonist	99.67%
Vanillyl butyl ether is a major contributor to the characteristic flavor and fragrance of vanilla. Vanillyl butyl ether is one of the eco-friendly and nontoxic substances. Vanillyl butyl ether exhibits mutually inhibitory effects on mammalian TRPV1 and TRPM8 channels. Vanillyl butyl ether shows repellency activity against Tribolium castaneum, T. confusum and L. bostrychophila. Vanillyl butyl ether acts as a mild warming agent, providing a warming sensation and enhancing blood circulation.

HY-101389

(R)-Methanandamide	Agonist
(R)-Methanandamide (AM-356), an analog of the endocannabinoid ligand Anandamide, is a potent CB1 agonist with a K_i of 20 nM. (R)-Methanandamide also activates vanilloid (TRPV1) receptors.

HY-114017

Libvatrep	Antagonist	99.54%
Vanilloid receptor antagonist 1 is a potent vanilloid receptor TRPV1 antagonist extracted from patent US8349852B2, compound B8.

HY-110018

N-Arachidonyldopamine	Agonist	98.36%
N-Arachidonyldopamine is a potent and selective endogenous CB1 receptor agonist with a K_i of 250 nM. N-Arachidonyldopamine is also a potent and selective TRPV1 agonist an with EC₅₀ of ~ 50 nM.

HY-160900

RN-1665	Antagonist	99.93%
RN-1665 is an orally active TRPV4 antagonist that exhibits excellent selectivity for related TRP receptors such as TRPV1, TRPV3 and TRPM8. RN-1665 is a TRPV4 probe for focus screens, with IC50s of 0.26 μM and 0.39 μM for hTRPV4 and rTRPV4 from human and rat, respectively.

HY-120962

N-Arachidonoyl Taurine	Activator	≥99.0%
N-Arachidonoyl Taurine is an activator of the transient receptor potential vanilloid TRPV1 and TRPV4, with EC₅₀s value of 28 μM and 21 μM, respectively.

HY-125527A

17(R)-Resolvin D1	Inhibitor	99.1%
17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells. 17R-Resolvin D1 specificially inhibits TRPV3 with an IC₅₀ of 398 nM and exhibits peripheral anti-nociceptive efficacy.

HY-162765

TRPV4-IN-5	Inhibitor
TRPV4-IN-5 (Compound 1f) is a potent TRPV4 inhibitor (IC₅₀ = 0.46 μM). TRPV4-IN-5 significantly alleviates the symptoms of acute lung injury induced by lipopolysaccharide (HY-D1056) in mice.

HY-124073

Dihydrocapsiate	Agonist	99.33%
Dihydrocapsiate, as a compound of capsinoid family, is an orally active TRPV1 agonist. Dihydrocapsiate can be used for the research of metabolism disease.

HY-10635

ABT-102	Antagonist
ABT-102 is a potent and highly selective Vanilloid Receptor (TRPV1) receptor antagonist. ABT-102 potently and reversibly increases heat pain thresholds and reduced painfulness of suprathreshold oral/cutaneous heat. ABT-102 reduces nociceptive responses of animals in models of inflammatory, bone cancer, postoperative, and osteoarthritic pain.

HY-12914

V116517	Antagonist
V116517 is a potent, orally active transient receptor potential vanilloid (TRPV1) antagonist. V116517 shows potent activity in inhibiting both capsaicin (CAP)- and acid (pH 5)-induced currents in rat DRG neurons expressing native TRPV (IC₅₀=423.2 nM for CAP; IC₅₀=180.3 nM for acid). V116517 can be used for the research of pain.

HY-P10762

CBP-1008	Ligand
CBP-1008 is a dual-ligand peptide-drug conjugate (PDC) conjugated to MMAE (HY-15162), targeting Folate receptor α (FRα) and TRPV6. CBP-1008 binds to FRα with high affinity and TRPV6 with low affinity. CBP-1008 has antitumor activity, and can be used in advanced solid tumor research (eg: colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma and follicular dendritic cell sarcoma).

HY-157766

FAAH/TRPV1 blocker-1	Inhibitor
FAAH/TRPV1 blocker-1 (compound 2R) is a dual FAAH/TRPV1 blocker, with IC₅₀ of 0.12 and 94.9 μM, respectively. FAAH/TRPV1 blocker-1 plays an important role in analgesic and anti-inflammatory research.

HY-149823

TRPV4 antagonist 4	Antagonist
TRPV4 antagonist 4 is a potent TRPV4 antagonist with an IC₅₀ value of 22.65 nM. TRPV4 antagonist 4 inhibits TRPV4 current. TRPV4 antagonist 4 shows protective effects on acute lung injury.

HY-19589

JTS-653	Antagonist
JTS-653 is a highly potent and selective transient receptor potential vanilloid 1 (TRPV1) antagonist in vitro and in vivo. JTS-653 attenuates chronic pain refractory to non-steroidal anti-inflammatory agents.

HY-P1175A

L-R4W2 TFA	Antagonist
L-R4W2 TFA is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 TFA may act as a potent analgesic.

HY-P1175

L-R4W2	Antagonist
L-R4W2 is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 may act as a potent analgesic.

HY-W517163

MK-2295	Antagonist
MK-2295 (NGD-8243) is a TRPV1 antagonist. MK-2295 is an analgesic agent, and can be used for research of pain.

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