2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-134701
    Acetamido-PEG2-Br
    Acetamido-PEG2-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Acetamido-PEG2-Br
  • HY-133162
    Mal-PEG1-Boc 810677-16-8
    Mal-PEG1-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG1-Boc
  • HY-132050
    Azido-PEG4-propargyl 1192590-91-2
    Azido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Azido-PEG4-propargyl
  • HY-138328
    Benzyl-PEG18-MS
    Benzyl-PEG18-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG18-MS
  • HY-138448
    m-PEG750-Br
    m-PEG750-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG750-Br
  • HY-135947
    Boc-NH-PEG11-OH 1556847-53-0
    Boc-NH-PEG11-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG11-OH
  • HY-140064
    Propargyl-PEG1-acrylate 52436-42-7
    Propargyl-PEG1-acrylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG1-acrylate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG1-acrylate
  • HY-138343
    Azido-PEG3-MS 176520-24-4
    Azido-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-MS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-MS
  • HY-132108
    Benzyl-PEG3-MS 702701-70-0
    Benzyl-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG3-MS
  • HY-143844B
    Bromo-PEG7-amine hydrobromide
    Bromo-PEG7-amine hydrobromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG7-amine hydrobromide
  • HY-140610
    Propargyl-PEG4-Sulfone-PEG4-acid 2055024-41-2
    Propargyl-PEG4-Sulfone-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-Sulfone-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-Sulfone-PEG4-acid
  • HY-140441
    Fmoc-aminooxy-PEG12-acid
    Fmoc-aminooxy-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-aminooxy-PEG12-acid
  • HY-168223
    Boc-Piperazine-2-F-Ph-CHO 501126-37-0
    Boc-Piperazine-2-F-Ph-CHO (Compound 2) is a PROTAC linker, used for the synthesis of YD54 (HY-168221) .
    Boc-Piperazine-2-F-Ph-CHO
  • HY-138769
    Azido-PEG12-alcohol 1111239-69-0
    Azido-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG12-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG12-alcohol
  • HY-141361
    (2-Pyridyldithio)-PEG2-Boc 2144777-73-9
    (2-Pyridyldithio)-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    (2-Pyridyldithio)-PEG2-Boc
  • HY-132035
    Benzyl-PEG13-alcohol
    Benzyl-PEG13-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG13-alcohol
  • HY-W096112
    TFP-PEG3-TFP 1446282-34-3 98.96%
    TFP-PEG3-TFP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    TFP-PEG3-TFP
  • HY-140093
    N-(PEG2-Boc)-N-bis(PEG2-propargyl) 2100306-69-0
    N-(PEG2-Boc)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(PEG2-Boc)-N-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N-(PEG2-Boc)-N-bis(PEG2-propargyl)
  • HY-138533
    Thiol-C10-amide-PEG8 1353948-95-4
    Thiol-C10-amide-PEG8 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-C10-amide-PEG8
  • HY-140790
    Azide-PEG9-amido-C12-Boc
    Azide-PEG9-amido-C12-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG9-amido-C12-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG9-amido-C12-Boc
PROTAC Linkers Isoform Comparison

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